Development of novel pro-drugs based on the bile acid as a core compound
Project/Area Number |
23590209
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Medical pharmacy
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Research Institution | Kinki University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
IKEGAWA Shigeo 近畿大学, 薬学部, 教授 (90111301)
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Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 胆汁酸 / N-アセチルシステイン / プロドラッグ / 肝・胆・消化機能改善薬 / 液体クロマトグラフィー / 質量分析法 / ウルソデオキシコール酸 / アフィニティー抽出 / 胆汁 / グルタチオン / システイン / グルタミン / LC/MS / 尿排泄 / 硫酸抱合 / 肝障害 / イメージング質量分析法 |
Research Abstract |
We demonstrated that N-acetylcysteine conjugate of ursodeoxycholic acid (UDCA-NAC) was hydrolyzed and circulated in body as UDCA after administration by injection via jugular vein, while UDCA-NAC converted to NAC-sulfate di-conjugate by rat liver cytosolic fraction. Furthermore, UDCA-NAC was shown to inhibit the increase of liver disease marker enzymes, AST and ALT, in serum of acetaminophen-induced liver injury rats. These results showed that UDCA-NAC is useful as a prodrug of the new liver, bile, digestive function improving agent.
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Report
(4 results)
Research Products
(64 results)
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[Journal Article] N-methyltaurine N-acyl amidated bile acids and deoxycholic acid in the bile of angelfish (Pomacanthidae): a novel bile acid profile in Perciform fish2014
Author(s)
Okihara, R.S.N., Saito, T., Ogata, H., Ohsaki, A., Iida, T., Asahina, K., Mitamura, K., Ikegawa, S., Hofmann, A.E., Hagey, L.R.
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Journal Title
Steroids
Volume: 80
Pages: 15-23
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] An efficient synthesis of 7alpha,12alpha-dihydroxy-4-cholesten-3-one and its biological precursor 7alpha-hydroxy-4-cholesten-3-one: Key intermediates in bile acid biosynthesis.2013
Author(s)
Ogawa S., Zhou B., Kimoto Y., Omura K., Kobayashi A., Higashi T., Mitamura K., Ikegawa S., Hagey L. R., Hofmann A. F., Iida T.
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Journal Title
Steroids
Volume: 78
Issue: 9
Pages: 927-937
DOI
Related Report
Peer Reviewed
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[Journal Article] Clostridium scindens: a human gut microbe with a high potential to convert glucocorticoids into androgens.2013
Author(s)
Ridlon J. M., Ikegawa S., Alves J. M., Zhou B., Kobayashi A., Iida T., Mitamura K., Tanabe G., Serrano M., De Guzman A., Cooper P., Buck G. A., Hylemon P. B.
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Journal Title
J.Lipid. Res.
Volume: 54
Issue: 9
Pages: 2437-2449
DOI
Related Report
Peer Reviewed
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[Journal Article] A novel varanic acid epimer—(24R, 25S)-3α,7α,12α,24-tetrahydroxy-5β- cholestan- 27-oic acid—is a major biliary bile acid in two varanid lizards and the Gila monster2012
Author(s)
Hagey LR, Ogawa S, Kato N, Satoh née Okihara R, Une M, Mitamura K, Ikegawa S, Hofmann AF, Iida T
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Journal Title
Steroids
Volume: 77
Issue: 13
Pages: 1510-1521
DOI
Related Report
Peer Reviewed
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[Journal Article] Involvement of SIK3 in Glucose and Lipid Homeostasis in Mice2012
Author(s)
Uebi T, Itoh Y, Hatano O, Kumagai A, Sanosaka M, Sasaki T, Sasagawa S, Doi J, Tatsumi K, Mitamura K, Morii E, Aozasa K, Kawamura T, Okumura M, Nakae J, et al.
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Journal Title
PLoS One
Volume: 7
Issue: 5
Pages: e37803-e37803
DOI
Related Report
Peer Reviewed
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[Presentation] Reversal of NAFL Through Selective Increased Intracellular Hepatic Cholesterol Catabolism2013
Author(s)
Kakiyama G. Marques D., Mitamura K., Ikegawa S., Ren S., Rodriguez-Agudo D., Copper P., Hylemon P., Zhou H., Pandak W. M.
Organizer
The Liver Meeting (AASLD 2013)
Place of Presentation
The Walter E. Washington Convention Center (Washington, DC, USA)
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