Clinical anatomic study and embryological study of the pelvic outlet muscles
| Project/Area Number |
23590216
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
AKITA Keiichi 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (80231819)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAGUCHI Kumiko 東京医科歯科大学, 医歯学融合教育支援センター, 講師 (90376799)
NIMURA Akimoto 東京医科歯科大学, 大学院医歯学総合研究科, 講師 (40622098)
HARADA Masayo 東京医科歯科大学, 大学院医歯学総合研究科, 助教 (80555756)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 解剖学 / 臨床解剖学 / 発生学 / 大腸肛門外科学 / 画像診断学 / 骨盤出口筋 / 直腸縦走筋 / 内外肛門括約筋 / 内肛門括約筋 / 外肛門括約筋 / 球海綿体筋 |
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| Research Abstract |
With the development of clinical devices and skills in anorectal region, detailed anatomical information is required in these days. We performed detailed gloss anatomical research and compared with the images of ultrasound, and magnetic resonance imaging. We also performed histological analyses with muscles and connective tissue surrounding the anal canal. Histological analyses were also performed with mouse embryos to add the information concerning developmental processes.
From these observations, we revealed the importance of longitudinal smooth muscle layer of the anal canal in human. The longitudinal muscle layer penetrated the external anal sphincter muscle. This structure is not observed in mice, and thought to be unique in human. After urorectal septum descend to separate the urogenital sinus and anorectal canal, it grew anteriorly, and contributed to the median raphe of external genitalia such as raphe of scrotum.
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Report
(4 results)
Research Products
(62 results)
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[Journal Article] Disruption of the temporally regulated cloaca endodermal β-catenin signaling causes anorectal malformations2014
Author(s)
Miyagawa S, Harada M, Matsumaru D, Tanaka K, Inoue C, Nakahara C, Haraguchi R, Matsushita S, Suzuki K, Nakagata N, Ng RC, Akita K, Lui VC, Yamada G.
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Journal Title
Cell Death Differ.
Volume: 21
Issue: 6
Pages: 990-997
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 骨盤底を学ぶ2012
Author(s)
秋田恵一
Organizer
第22回骨盤外科機能温存研究会
Place of Presentation
東京
Year and Date
2012-06-23
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