Regionalization of the axial skeleton derived from the somites: its ontogenesis and phylogenesis
| Project/Area Number |
23590219
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Hiroshima University |
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Principal Investigator |
AOYAMA Hirohiko 広島大学, 医歯薬保健学研究院, 教授 (70143948)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUI Kouji 広島大学, 大学院医歯薬保健学研究院, 助教 (80183945)
SAKAMOTO Nobuyuki 広島大学, 大学院医歯薬保健学研究院, 助教 (90346487)
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| Research Collaborator |
FAN Haiming 広島大学, 大学院医歯薬学総合研究科
MATSUMORI Daisuke 広島大学, 大学院医歯薬学総合研究科
MASUDA Tasuku 広島大学, 大学院医歯薬学総合研究科
KATSURA Yukari 広島大学, 大学院医歯薬学総合研究科
CHAOKEJILE 広島大学, 大学院医歯薬学総合研究科
MATSUTANI Kaoru 広島大学, 大学院医歯薬学総合研究科
SHIMURA Nahoko 広島大学, 大学院医歯薬学総合研究科
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 形態形成 / 軸骨格 / 体節 / 側板 / 肋骨 / 接触阻止 / ニワトリ / 進化 / 部域特異性 / ニワトリ胚 / マウス胚 / 軟骨形成 / 骨化 / 側板中胚葉 / 表皮外胚葉 / Wnt / 細胞移動 / 部域化 / 体節中胚葉 / 組織間相互作用 / マウス / 比較発生学 |
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| Research Abstract |
In the axial skeleton of mammals and birds, the ribs are exclusively in the thoracic region. The most part of the rib is consisuted of the distal rib, which develops depending on the surface ectoderm. Regionalization of the axial skeleton is, thus, considered to be differential development of the distal rib according to its location. An ectopic transplantation of the thoracic somite into the lumbosacral region in a 2-day chick embryo caused ectopic rib, which was shorter than the normal rib. In the course of development of this chimera, we found that the thoracic somite cells stopped their migration when they met the lumbosacral lateral plate mesoderm.
On the other hand, we compared the axial skeleton development between chick embryos and mouse embryos and found that order of the ossification was different, which coincide with an idea that the regionalization of the axial skeleton independently occurs in the course of phylogenesis of mammals and birds.
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Report
(4 results)
Research Products
(39 results)
