| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
|
|---|
| Research Abstract |
Male and female ferrets at postnatal days (PDs) 4 to 90 were perfused with 4% paraformaldehyde solution, and the brains were removed. The chronology of sulcal and gyral emergences were clarified using those brain samples by gross anatomic observations. T1W-MRI was further acquired from the fixed brain using a high spatial resolution 7-tesla MRI. T1W-MRI-based maximum intensity projection (MIP) could delineate functional cortical areas related to myeloarchitecure in 3D. Quantitative analysis of the sulcal infolding revealed a male-prominent posterior extension of neocortical and archicortical sulci with cortical expansion in the temporo-parieto-occipital region of the cerebrum. Fractional anisotropy was measured in the subcortical white matter of the sulcal and gyral regions of the ferret cerebra using diffusion tensor imaging (DTI). However, it was unclear a relation of sulcal development with the development of subcortical white matter bundles.
|
