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Roles of the androgen receptor in the sexual differentiation in the mouse submandibular gland

Research Project

Project/Area Number 23590231
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General anatomy (including Histology/Embryology)
Research InstitutionKanazawa University

Principal Investigator

ISEKI Shoichi  金沢大学, 医学系, 教授 (50167251)

Co-Investigator(Renkei-kenkyūsha) WAKAYAMA Tomohiko  金沢大学, 医学系, 准教授 (70305100)
MIYUKI Yamamoto  金沢大学, 医学系, 助教 (60139780)
NAKAYA Masaaki  金沢大学, 医学系, 助教 (70422095)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords細胞分化 / 組織形成 / 顎下腺 / 顆粒性導管 / アンドロゲン / アンドロゲン受容体 / 甲状腺ホルモン / 導管系 / 性差 / 受容体 / 唾液腺 / マウス
Research Abstract

We examined the SMG of mice deficient of the androgen receptor (ARKO). The development of granular convoluted tubules (GCT) in ARKO male was as low as in control female. The administration of androgens had no effect, whereas the administration of thyroid hormone (T4) caused the conversion of striated duct cells into GCT cells in ARKO SMG. These results confirmed that GCT differentiation caused by androgens is dependent on the classical androgen receptor (AR), whereas that by T4 is independent of the AR. Analysis of the gene expression profiles in ARKO SMG revealed new GCT-specific genes as well as genes up-or down-regulated in the SMG by androgens without involvement of the classical AR.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report

Research Products

(27 results)

All 2014 2013 2012 2011 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (22 results) (of which Invited: 2 results) Remarks (1 results)

  • [Journal Article] Expression and localization ofα-amylase in the submandibular and sublingual glands of mice2014

    • Author(s)
      Yamagishi R, Wakayama T, Nakata T, Adthapanyawanich K, Kumchantuek T, Yamamoto M, Iseki S
    • Journal Title

      Acta Histochemica et Cytochemica

      Volume: (印刷中)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression and localization of α-amylase in the submandibular and sublingual glands of mice2014

    • Author(s)
      Ryoko Yamagishi, Tomohiko Wakayama, Hiroki Nakata, Kannika Adthapanyawanich, Tewarat Kumchantuek, Miyuki Yamamoto, and Shoichi Iseki
    • Journal Title

      Acta Histochemica et Cytochemica

      Volume: 47

    • NAID

      130004137835

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression and localization of receptor protein tyrosine phosphataseβand its ligand pleiotrophin in the submandibular gland of mice2013

    • Author(s)
      Adthapanyawanich K, Yamamoto M, Wakayama T, Nakata H, Keattikunpairoj S, Iseki S
    • Journal Title

      Archives of Oral Biology

      Volume: 58 Pages: 181-191

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression and localization of receptor protein tyrosine phosphatase b and its ligand pleiotrophin in the submandibular gland of mice2013

    • Author(s)
      Adthapanyawanich K, Yamamoto M, Wakayama T, Nakata H, Keattikunpairoj S, Iseki S
    • Journal Title

      Archives of Oral Biology

      Volume: 58 Pages: 181-191

    • DOI

      10.1016/j.archoralbio.2012.09.005

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] マウス顎下腺の生後発達過程におけるケラチン5免疫陽性前駆細胞の発現動態2014

    • Author(s)
      山本美由紀、井関尚一
    • Organizer
      第119回日本解剖学会総会・全国学術集会
    • Place of Presentation
      自治医科大学キャンパス(栃木県)
    • Related Report
      2013 Final Research Report
  • [Presentation] アンドロゲン受容体欠損マウス顎下腺の形態と遺伝子発現2014

    • Author(s)
      井関尚一、Adthapanyawanich K、若山友彦、山本美由紀、仲田浩規、Kumchantuek T、山岸諒子、西内巧
    • Organizer
      第119回日本解剖学会総会・全国学術集会
    • Place of Presentation
      自治医科大学キャンパス(栃木県)
    • Related Report
      2013 Final Research Report
  • [Presentation] アンドロゲン受容体欠損マウス顎下腺の形態と遺伝子発現2014

    • Author(s)
      井関尚一、Kannika Adthapanyawanich、若山友彦、山本美由紀、仲田浩規、Tewarat Kumchantuek、山岸諒子、西内巧
    • Organizer
      第119回日本解剖学会総会・全国学術集会
    • Place of Presentation
      自治医科大学キャンパス
    • Related Report
      2013 Annual Research Report
  • [Presentation] マウス顎下腺の生後発達過程におけるケラチン5免疫陽性前駆細胞の発現動態2014

    • Author(s)
      山本美由紀、井関尚一
    • Organizer
      第119回日本解剖学会総会・全国学術集会
    • Place of Presentation
      第119回日本解剖学会総会・全国学術集会
    • Related Report
      2013 Annual Research Report
  • [Presentation] マウス顎下腺および舌下腺におけるαアミラーゼの発現と局在.2013

    • Author(s)
      山岸諒子、Adthapanyawanich K、仲田浩規、山本美由紀、若山友彦、井関尚一
    • Organizer
      第73回日本解剖学会中部支部学術集会
    • Place of Presentation
      山梨大学甲府キャンパス(山梨県)
    • Related Report
      2013 Final Research Report
  • [Presentation] The classical and non-classical actions of androgens in the submandibular gland of mice2013

    • Author(s)
      Adthapanyawanich K, Yamagishi R, Kumchantuek T, Iseki S
    • Organizer
      第118回日本解剖学会総会・全国学術集会
    • Place of Presentation
      サンポートホール高松(香川県)
    • Related Report
      2013 Final Research Report
  • [Presentation] マウス顎下腺の生後発達におけるケラチン5発現細胞の局在2013

    • Author(s)
      山本美由紀、井関尚一
    • Organizer
      第118回日本解剖学会総会・全国学術集会
    • Place of Presentation
      サンポートホール高松(香川県)
    • Related Report
      2013 Final Research Report
  • [Presentation] マウス顎下腺および舌下腺におけるαアミラーゼの発現と局在2013

    • Author(s)
      山岸諒子、Kannika Adthapanyawanich、仲田浩規、山本美由紀、若山友彦、井関尚一
    • Organizer
      第73回日本解剖学会中部支部学術集会
    • Place of Presentation
      山梨大学甲府キャンパス
    • Related Report
      2013 Annual Research Report
  • [Presentation] マウス顎下腺の生後発達におけるケラチン5発現細胞の局在2013

    • Author(s)
      山本美由紀、井関尚一
    • Organizer
      第118回日本解剖学会総会・全国学術集会
    • Place of Presentation
      サンポートホール高松、香川
    • Related Report
      2012 Research-status Report
  • [Presentation] The classical and non-classical actions of androgens in the submandibular gland of mice2013

    • Author(s)
      Kannkika Adthapanyawanich, Ryoko Yamagishi, Tewarat Kumchantuek, Shoichi Iseki
    • Organizer
      第118回日本解剖学会総会・全国学術集会
    • Place of Presentation
      サンポートホール高松、香川
    • Related Report
      2012 Research-status Report
  • [Presentation] The duct system of mouse submandibular gland as a model of hormone-dependent cell differentiation2012

    • Author(s)
      Iseki S
    • Organizer
      The 4th Japan-Korea Joint Symposium on Recent Advance in Medical Science
    • Place of Presentation
      Kanazawa University, Ishikawa
    • Year and Date
      2012-11-07
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Study on the submandibular gland of androgen-deficient mice2012

    • Author(s)
      Adthapanyawanich K, Nakata H, Yamamoto M, Yamagishi R, Wakayama T, Iseki S
    • Organizer
      15th International Congress on Hormonal Steroids and Hormones and Cancer
    • Place of Presentation
      Kanazawa University, Ishikawa
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] アンドロゲン受容体欠損マウスにおける顎下腺の研究2012

    • Author(s)
      山岸諒子、Kannika A、仲田浩規、山本美由紀、若山友彦、井関尚一
    • Organizer
      第72回日本解剖学会中部支部学術集会
    • Place of Presentation
      じゅうろくプラザ(岐阜県)
    • Related Report
      2013 Final Research Report
  • [Presentation] Studies on the submandibular gland of androgen-receptor-deficient mice2012

    • Author(s)
      Adthapanyawanich K, Nakata H, Yamamoto, M, Yamagishi R, Wakayama T, Iseki S
    • Organizer
      14th International Congress of Histochemistry and Cytochemistry
    • Place of Presentation
      Kyoto International Conference Center, Kyoto
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] マウス顎下腺におけるケラチン5発現細胞2012

    • Author(s)
      山本美由紀, 井関尚一
    • Organizer
      第117回日本解剖学会総会・全国学術集会
    • Place of Presentation
      山梨大学甲府キャンパス(山梨県)
    • Related Report
      2013 Final Research Report
  • [Presentation] Studies on the submandibular gland of androgen receptor-deficient mice2012

    • Author(s)
      Adthapanyawanich K, Nakata H, Wakayama T, Iseki S
    • Organizer
      第117回日本解剖学会総会・全国学術集会
    • Place of Presentation
      山梨大学甲府キャンパス(山梨県)
    • Related Report
      2013 Final Research Report
  • [Presentation] アンドロゲン受容体欠損マウスにおける顎下腺の研究2012

    • Author(s)
      山岸諒子、Adthapanyawanich Kannika、仲田浩規、山本美由紀、若山友彦、井関尚一
    • Organizer
      第72回日本解剖学会中部支部学術集会
    • Place of Presentation
      じゅうろくプラザ、岐阜
    • Related Report
      2012 Research-status Report
  • [Presentation] The duct system of mouse submandibular gland as a model of hormone- dependent cell differentiation2012

    • Author(s)
      Shoichi Iseki
    • Organizer
      The 4th Japan-Korea Joint Symposium on Recent Advance in Medical Science
    • Place of Presentation
      Kanazawa University, Ishikawa
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] マウス顎下腺におけるケラチン5発現細胞2012

    • Author(s)
      山本美由紀、井関尚一
    • Organizer
      第117回日本解剖学会総会・全国学術集会
    • Place of Presentation
      山梨大学甲府キャンパス(山梨県)
    • Related Report
      2011 Research-status Report
  • [Presentation] Studies on the submandibular gland of androgen receptor-deficient mice2012

    • Author(s)
      Kannika Adthapanyawanich, Hiroki Nakata, Tomohiko Wakayama, Shoichi Iseki
    • Organizer
      第117回日本解剖学会総会・全国学術集会
    • Place of Presentation
      山梨大学甲府キャンパス(山梨県)
    • Related Report
      2011 Research-status Report
  • [Presentation] Expression and localization of receptor protein tyrosine phosphataseβin the submandibular gland of mice2011

    • Author(s)
      Adthapanyawanich K, Wakayama T, Yamamoto M, Iseki S
    • Organizer
      第52回日本組織細胞化学会総会・学術集会
    • Place of Presentation
      金沢大学宝町キャンパス(石川県)
    • Related Report
      2013 Final Research Report
  • [Presentation] Expression and localization of receptor protein tyrosine phosphatase β in the submandibular gland of mice2011

    • Author(s)
      Kannika Adthapanyawanich, Tomohiko Wakayama, Miyuki Yamamoto, Shoichi Iseki
    • Organizer
      第52回日本組織細胞化学会総会・学術集会
    • Place of Presentation
      金沢大学宝町キャンパス(石川県)
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://ana1.w3.kanazawa-u.ac.jp/

    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-08-04   Modified: 2019-07-29  

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