Effect of troponin C affinity for Ca2+ on the frequency of arrhythmias
Project/Area Number |
23590253
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General physiology
|
Research Institution | Tohoku University |
Principal Investigator |
MIURA Masahito 東北大学, 医学(系)研究科(研究院), 准教授 (30302110)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | カルシウム波 / カルシウム親和性 / 遅延後脱分極 / 国際情報交流 |
Research Abstract |
In cardiac ventricular muscle, the affinity of the myofilaments for Ca2+ determined the propagation velocity of Ca2+ waves. Also in the failing muscle, an increase in their affinity increased the propagation velocity. In the muscle with a regional increase in [K+]o, the increase in their affinity due to nonuniform muscle contraction increased the propagation velocity. These results suggest that the affinity of the myofilaments is an important determinant for the initiation and the frequency of ventricular arrhythmias probably by changing the velocity of Ca2+ waves.
|
Report
(4 results)
Research Products
(48 results)
-
-
-
-
-
-
-
[Journal Article] A Sodium Channel Blocker, Pilsicainide, Produces Atrial Post-Repolarization Refractoriness through the Reduction of Sodium Channel Availability2011
Author(s)
Fukuda K, Watanabe J, Yagi T, Wakayama Y, Nakano M, Kondo M, Kumagai K, Miura M, Shirato K, Shimokawa H
-
Journal Title
The Tohoku Journal of Experimental Medicine
Volume: 225
Issue: 1
Pages: 35-42
DOI
NAID
ISSN
0040-8727, 1349-3329
Related Report
Peer Reviewed
-
-
[Journal Article] Acceleration of Ca2+ Waves in Monocrotaline-Induced Right Ventricular Hypertrophy in the Rat2011
Author(s)
Miura M, Hirose M, Endoh H, Wakayama Y, Sugai Y, Nakano M, Fukuda K, Shindoh C, Shirato K, Shimokawa H
-
Journal Title
Circulation Journal
Volume: 75
Issue: 6
Pages: 1343-1349
DOI
NAID
ISSN
1346-9843, 1347-4820
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-