Contribution of the spontaneous calcium rhythm to the state of the striatal network
| Project/Area Number |
23590255
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Tohoku University |
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Principal Investigator |
OSANAI Makoto 東北大学, 医学(系)研究科(研究院), 准教授 (90286419)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | カルシウム振動 / 大脳基底核 / カルシウムイメージング / 代謝型グルタミン酸受容体 / IP3 受容体 / ニューロン・グリア相互作用 / パーキンソン病 / 細胞間相関 / カルシウムオシレーション / 小胞体 / カルシウム依存性カリウムチャネル / カルシウムリズム / 基底核 / イメージング / シミュレーション |
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| Research Abstract |
Ca2+ is a universal signal transduction molecule. To characterize Ca2+ signaling in striatal cells, spontaneous Ca2+ rhythms were examined in slice preparations. In both neurons and astrocytes of the striatum, spontaneous slow and long-lasting intracellular Ca2+ rhythms, which lasted up to 200 s, were found. Depletion of the intracellular Ca2+ store and the blockade of IP3 receptors reduced the transient rate of the Ca2+ rhythm, and an mGluR5 antagonist blocked the Ca2+ rhythms in both neurons and astrocytes. Thus, the mGluR5-IP3 signal cascade is the primary contributor to the Ca2+ rhythm in both neurons and astrocytes. The Ca2+ rhythm features multicellular synchrony, and both neurons and astrocytes participate in the synchronous activity. Therefore, the Ca2+ rhythm may involve in the neuron-glia interaction in the striatum. In the simulation study, we found that the Ca2+ rhythm can modulate the firing properties of the medium spiny projection neurons via Ca2+-activated K+ channels.
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Report
(4 results)
Research Products
(88 results)
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[Journal Article] 死後経過時間による脳CT画像の変化2013
Author(s)
臼井 章仁, 細貝 良行, 川住 祐介, 中島 彩, 安孫子 絹太, 小堺 雅貴, 齋藤 春夫, 舟山 眞人, 小山内 実
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Journal Title
電気学会 電子・情報・システム部門大会講演論文集
Volume: 平成 25 年
Pages: 134-137
Related Report
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[Journal Article] Markerless Lung Tumor Motion Tracking by Dynamic Decomposition of X-ray Image Intensity2013
Author(s)
N. Homma, Y. Takai, H. Endo, K. Ichiji, Y. Narita, X. Zhang, M. Sakai, M. Osanai, M. Abe, N. Sugita, M. Yoshizawa
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Journal Title
Journal of Medical Engineering
Volume: Vol.2013
Pages: 340821-340821
DOI
Related Report
Peer Reviewed
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[Presentation] 死後経過時間による脳CT画像の変化2013
Author(s)
臼井 章仁, 細貝 良行, 川住 祐介, 中島 彩, 安孫子 絹太, 小堺 雅貴, 齋藤 春夫, 舟山 眞人, 小山内 実
Organizer
平成 25 年電気学会 電子・情報・システム部門大会
Place of Presentation
北見
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