| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
Tight junctions, which seal adjacent epithelial cells in a narrow band, composes a large complex of proteins including transmembrane, scaffolding, and transcriptional proteins. Claudins are tetraspanning proteins and comprise a superfamily of more than 20 homologus isoforms. Different combinations of claudins can confer different properties to epithelial cells. However, the regulatory mechanisms of claudins expression remain largely unknown. We investigated the regulatory mechanisms of claudins expression in the renal tubule and found the novel transcriptional mechanism of claudin-2 and -4, and intracellular trafficking mechanism of claudin-16. Furthermore, we clarified the novel function of claudin-2 and -4 against hyperosmotic stress.
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