Regulatory mechanism for ion transporters in renal tubules
| Project/Area Number |
23590265
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Teikyo University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
ABE Takaaki 東北大学, 大学院医工学研究科, 教授 (80292209)
KAWAHARA Katsumasa 北里大学, 医学部, 教授 (70134525)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | カリウムチャネル / 尿細管輸送 / 細胞内局在 / Gitelman症候群 / EAST症候群 / 電解質恒常性 / ナトリウム輸送 |
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| Outline of Final Research Achievements |
The distal convoluted tubule (DCT) of the kidney is the regulatory segment for the electrolyte homeostasis. At the DCT, basolaterally expressed Na+/K+ ATPase provides the driving force for electrolyte transport and the process of K+ excretion, known as K+ recycling, is the rate-limiting step in the electrolyte transport at the DCT. The functional defect in the K+ pathway reduces the K+ recycling and causes salt waste from the kidney. In this study, we found that intracellular mistrafficking of the K+ pathway of the basolateral side contributes to the pathogenesis of renal salt waste.
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Report
(5 results)
Research Products
(50 results)
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[Journal Article] Blood pressure control and satisfaction of hypertensive patients following a switch to combined drugs of an angiotensin receptor blocker and a calcium channel blocker in clinical practice of nephrology. Clinical and Experimental Nephrology.2015
Author(s)
Kato H, Shiraishi T, Ueda S, Kubo E, Shima T, Nagura M, Yano H, Izumikawa Y, Shimada M, Tomioka S, Nosaka H, Kojima K, Tanemoto M, Uchida S
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Journal Title
Clin Exp Nephrol.
Volume: 19
Issue: 3
Pages: 465-473
DOI
Related Report
Peer Reviewed
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[Journal Article] Therapeutic dose of acetaminophen as a possible risk factor for acute kidney injury: learning from two healthy young adult cases.2014
Author(s)
Kato H, Fujigaki Y, Inoue R, Asakawa S, Shin S, Shima T, Furunishi J, Higaki M, Tanemoto M, Yamaguchi Y, Hoshimoto K, Uozaki H, Uchida S.
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Journal Title
Intern Med.
Volume: 53
Pages: 1531-1534
NAID
Related Report
Peer Reviewed
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[Journal Article] Luminal alkalinization attenuates proteinuria-induced oxidative damage in proximal tubular cells2011
Author(s)
Souma T, Abe M, Moriguchi T, Takai J, Yanagisawa-Miyazawa N, Shibata E, Akiyama Y, Toyohara T, Suzuki T, Tanemoto M, Abe T, Sato H, Yamamoto M, Ito S
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Journal Title
J Am Soc Nephrol
Volume: 22
Issue: 4
Pages: 635-648
DOI
Related Report
Peer Reviewed
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[Presentation] カリウム代謝異常2014
Author(s)
種本雅之
Organizer
第44回日本腎臓学会東部学術総会
Place of Presentation
新宿
Year and Date
2014-10-24 – 2014-10-25
Related Report
Invited
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[Presentation] 虚血性腎疾患2014
Author(s)
種本雅之
Organizer
第57回日本腎臓学会学術総会
Place of Presentation
横浜
Year and Date
2014-07-04 – 2014-07-06
Related Report
Invited
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