| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The distal convoluted tubule (DCT) of the kidney is the regulatory segment for the electrolyte homeostasis. At the DCT, basolaterally expressed Na+/K+ ATPase provides the driving force for electrolyte transport and the process of K+ excretion, known as K+ recycling, is the rate-limiting step in the electrolyte transport at the DCT. The functional defect in the K+ pathway reduces the K+ recycling and causes salt waste from the kidney. In this study, we found that intracellular mistrafficking of the K+ pathway of the basolateral side contributes to the pathogenesis of renal salt waste.
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