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Development of novel mathematical models for human cardiac myocytes based on bifurcation analysis and comparative study

Research Project

Project/Area Number 23590266
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General physiology
Research InstitutionKanazawa Medical University

Principal Investigator

KURATA Yasutaka  金沢医科大学, 医学部, 准教授 (00267725)

Co-Investigator(Kenkyū-buntansha) SHIBAMOTO Toshishige  金沢医科大学, 医学部, 教授 (90178921)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywordsシステム生理 / フィジオーム / ヒト心筋モデル / 分岐解析 / システム生理学 / 非線形力学 / 分岐理論 / 生物・生体工学 / 生物物理 / 生理学
Research Abstract

The aim of this study was to develop novel mathematical models for human cardiac myocytes which can well reproduce experimental data and are suitable for mathematical analyses. We first constructed the database of previous mathematical models of human and animal cardiac myocytes for model development. Based on the database, we have developed novel human ventricular and atrial myocyte models which are improved versions of previous models. To develop Purkinje and sinoatrial node cell models, we further compared the experimental data on expression of ion channels in individual cell types. Novel Purkinje and sinoatrial node cell models have been developed by parameter adjustment according to the the expression data and by analyzing bifurcation structures during inhibition of the inward-rectifier potassium channel current and incorporation of the hyperpolarization-activated cation channel current. These novel model cells are useful as modules for development of human heart models.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (12 results)

All 2014 2013 2012 2011 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (8 results)

  • [Journal Article] Effect of hyper- polarization-activated current I_f on robustness of sinoatrial node pacemaking : theoretical study on influence of intracellular Na^+ concentration2013

    • Author(s)
      Kurata Y, Hisatome I, Tanida M, Shibamoto T
    • Journal Title

      Am J Physiol Heart Circ Physiol

      Volume: 304 Pages: 1337-1351

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Roles of sarcoplasmic reticulum Ca^2+ cycling and Na^+/Ca^2+ exchanger in sinoatrial node pacemaking : insights from bifurcation analysis of mathematical models2012

    • Author(s)
      Kurata Y, Hisatome I, Shibamoto T
    • Journal Title

      Am J Physiol Heart Circ Physiol

      Volume: 302 Pages: 2285-2300

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of hyperpolarization-activated current If on robustness of sinoatrial node pacemaking: theoretical study on influence of intracellular Na+ concentration2012

    • Author(s)
      Kurata Y
    • Journal Title

      Am J Physiol Heart Circ Physiol

      Volume: 304 Issue: 10 Pages: 61-7

    • DOI

      10.1152/ajpheart.00777.2012

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of sarcoplasmic reticulum Ca2+ cycling and Na+/Ca2+ exchanger in sinoatrial node pacemaking: Insights from bifurcation analysis of mathematical models.2012

    • Author(s)
      Kurata Y
    • Journal Title

      American Journal of Physiology (Heart Circ Physiol)

      Volume: 302 Issue: 11 Pages: H2285-H2300

    • DOI

      10.1152/ajpheart.00221.2011

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Dynamical mechanisms of early afterdepolarizations in long QT syndromes : insights from bifurcation analysis of mathematical models for human ventricular myocytes2014

    • Author(s)
      Kurata Y, Hisatome I, Tanida M, Shibamoto T
    • Organizer
      The 91st Annual Meeting of The Physiological Society of Japan
    • Place of Presentation
      Kagoshima(J Physiol Sci 64 (Suppl 1): S180)
    • Related Report
      2013 Final Research Report
  • [Presentation] Effect of hyperpolarization-activated current I_f on robustness of sinoatrial node pacemaking : theoretical study in connection with intracellular Na^+ concentration changes2013

    • Author(s)
      Kurata Y, Hisatome I, Shibamoto T
    • Organizer
      The 90th Annual Meeting of The Physiological Society of Japan
    • Place of Presentation
      Tokyo(J Physiol Sci 63 (Suppl 1): S178)
    • Related Report
      2013 Final Research Report
  • [Presentation] Effect of hyperpolarization-activated current If on robustness of sinoatrial node pacemaking: theoretical study in connection with intracellular Na+ concentration changes.2013

    • Author(s)
      Kurata Y
    • Organizer
      The 90th annual meeting of the physiological society of Japan
    • Place of Presentation
      Tokyo, Japan (Tower Hall Funabori)
    • Related Report
      2012 Research-status Report
  • [Presentation] Roles of sarcoplasmic reticulum Ca^2+ clock and Na^+/Ca^2+ exchanger in sinoatrial node pacemaking : Insights from bifurcation analysis of mathematical models(Intracellular Ca clock and cell excitation)2012

    • Author(s)
      Kurata Y, Hisatome I, Shibamoto T
    • Organizer
      The 89th Annual Meeting of The Physiological Society of Japan
    • Place of Presentation
      Matsumoto(62(Suppl 1): S18)
    • Related Report
      2013 Final Research Report
  • [Presentation] 過分極活性化陽イオンチャネル電流の洞結節細胞ロバスト性への影響:モデル細胞の分岐構造解析による理論的検証2012

    • Author(s)
      倉田康孝, 久留一郎, 芝本利重
    • Organizer
      第29回日本心電学会学術集会
    • Place of Presentation
      千葉(日本心電学会誌・心電図, 32(Suppl 5): S-5-172)
    • Related Report
      2013 Final Research Report
  • [Presentation] 洞結節自動能の発現におけるNa/Ca交換体および筋小胞体Caクロックの役割:モデルシステムの分岐構造解析による検証2011

    • Author(s)
      倉田康孝, 久留一郎, 芝本利重
    • Organizer
      第28回日本心電学会学術集会
    • Place of Presentation
      福岡(日本心電学会誌・心電図, 31(Suppl 4): 298)
    • Related Report
      2013 Final Research Report
  • [Presentation] QT延長症候群における早期後脱分極発現の力学的機序:ヒト心室筋細胞モデルの分岐構造解析による検証

    • Author(s)
      倉田康孝、久留一郎、谷田 守、芝本利重
    • Organizer
      第30回日本心電学会学術集会
    • Place of Presentation
      青森市文化会館(青森市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Dynamical mechanisms of early afterdepolarizations in long QT syndromes: insights from bifurcation analysis of mathematical models for human ventricular myocytes

    • Author(s)
      Kurata Y, Hisatome I, Tanida M, Shibamoto T
    • Organizer
      The 91st Annual Meeting of the physiological society of Japan
    • Place of Presentation
      鹿児島大学・郡元キャンパス(鹿児島市)
    • Related Report
      2013 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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