Mechanism of synaptic transmission underlying memory formation for male mouse pheromones
| Project/Area Number |
23590279
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Kochi University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 行動生理学 / 鋤鼻系 / 電気生理学 / 代謝型グルタミン酸受容体 / シグナル伝達 / 相反性シナプス |
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| Research Abstract |
We investigated the effect of group II metabotropic glutamate receptors (mGluR2) on reciprocal synaptic responses (DDI) measured from mitral or granule cells in slice preparations from mice AOB with using the patch-clamp technique. Miniature EPSCs recorded from granule cells were reduced in both their frequency and amplitudes by an agonist for mGluR2, DCG-IV, suggesting that mGluR2 can modulate the synaptic transmission from mitral to granule cells through both pre- and postsynaptic mechanisms. Additionally, DCG-IV inhibited Ca2+ currents in both mitral and granule cells.
To see whether mGluR2 has similar effects on the DDI elicited by more physiological stimuli, IPSPs triggered by spike trains in mitral cells were recorded. LY341495, an antagonist for mGluR2, enhanced it. The present results suggest that mGluR2 can be activated by endogenous glutamate release from mitral cells, which results in the suppression of the synaptic transmission from mitral to granule cells in the AOB.
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Report
(4 results)
Research Products
(32 results)
