| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
We investigated the effect of group II metabotropic glutamate receptors (mGluR2) on reciprocal synaptic responses (DDI) measured from mitral or granule cells in slice preparations from mice AOB with using the patch-clamp technique. Miniature EPSCs recorded from granule cells were reduced in both their frequency and amplitudes by an agonist for mGluR2, DCG-IV, suggesting that mGluR2 can modulate the synaptic transmission from mitral to granule cells through both pre- and postsynaptic mechanisms. Additionally, DCG-IV inhibited Ca2+ currents in both mitral and granule cells.
To see whether mGluR2 has similar effects on the DDI elicited by more physiological stimuli, IPSPs triggered by spike trains in mitral cells were recorded. LY341495, an antagonist for mGluR2, enhanced it. The present results suggest that mGluR2 can be activated by endogenous glutamate release from mitral cells, which results in the suppression of the synaptic transmission from mitral to granule cells in the AOB.
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