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Role of orexin system in coordinating ultradian rhythm

Research Project

Project/Area Number 23590280
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionKagoshima University

Principal Investigator

OOTSUKA Youichirou  鹿児島大学, 医歯(薬)学総合研究科, 客員研究員 (70302403)

Co-Investigator(Renkei-kenkyūsha) YAMANAKA Akihiro  名古屋大学, 環境医学研究科, 教授 (60323292)
KUWAKI Tomoyuki  鹿児島大学, 大学院医歯学総合研究科, 教授 (80205260)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsオレキシン / 生体リズム / 遺伝子改変マウス / 超日生体リズム / 国際交流研究(オーストラリア) / 国際情報交流(オーストラリア)
Research Abstract

The aim of the present project is to explore brain system that coordinates the ultradian rhythm, focusing orexin, a neuropeptide that is important to promote wakefulness. The project investigated ultradian pattern in genetically-modified mice that have a deficient of orexin or of orexin neurons. In the wild type, body temperature and heat rate increased episodically at every approximately 90 min, confirming the existence of the ultradian rhythm in mice as with rats. In orexin-related transgenic mice, the amplitude of ultradian increase in body temperature and locomotor activity was significantly reduced. The project also employed optogenetically-modified mice in which orexin neuronal activity can be controlled by focal light illumination. Long lasting activation of orexin neurons attenuated the amplitude of the ultradian rhythm. These data suggest that orexin system is important for coordinating ultradian rhythm in body temperature and locomotor activity.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (51 results)

All 2014 2013 2012 2011 Other

All Journal Article (7 results) (of which Peer Reviewed: 5 results) Presentation (44 results) (of which Invited: 5 results)

  • [Journal Article] Brown adipose tissue thermogenesis contributes to emotional hyperthermia in a resident rat suddenly confronted with an intruder rat2014

    • Author(s)
      Mohammed M, Ootsuka Y, Blessing W
    • Journal Title

      Am J Physiol

      Volume: 305 Issue: 6 Pages: R394-R400

    • DOI

      10.1152/ajpregu.00475.2013

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Brown adipose tissue thermogenesis, the basic rest-activity cycle, meal initiation, and bodily homeostasis in rats2013

    • Author(s)
      Blessing W, Mohammed M, Ootsuka Y.
    • Journal Title

      Physiol Behav.

      Volume: 印刷中 Pages: 61-69

    • DOI

      10.1016/j.physbeh.2013.03.028

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 交感神経活動の中枢神経回路2013

    • Author(s)
      大塚曜一郎, 桑木共之
    • Journal Title

      Cardiovascular Frontier

      Volume: 第17号 Pages: 15-20

    • Related Report
      2013 Final Research Report
  • [Journal Article] Inactivation of neuronal function in the amygdaloid region reduces tail artery blood flow alerting responses in conscious rats2013

    • Author(s)
      Mohammed M, Kulasekara K, De Menezes RC, Ootsuka Y, Blessing WW
    • Journal Title

      Neuroscience

      Volume: 228 Pages: 13-22

    • DOI

      10.1016/j.neuroscience.2012.10.008

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Brown adipose tissue thermogenesis precedes food intake in genetically obese Zucker (fa/fa) rats2013

    • Author(s)
      Kontos A, de Menezes RC, Ootsuka Y, Blessing W
    • Journal Title

      Physiol Behav

      Volume: 118 Pages: 129-137

    • DOI

      10.1016/j.physbeh.2013.05.021

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 交感神経活動調節の中枢神経回路2013

    • Author(s)
      大塚曜一郎、桑木共之
    • Journal Title

      Cardiovascular Frontier

      Volume: 4 Pages: 15-20

    • Related Report
      2013 Annual Research Report 2012 Research-status Report
  • [Journal Article] Heating and eating: brown adipose tissue thermogenesis precedes food ingestion as part of the ultradian basic rest-activity cycle in rats2012

    • Author(s)
      Blessing W, Mohammed M, Ootsuka Y.
    • Journal Title

      Physiol Behav.

      Volume: 105 Issue: 4 Pages: 966-974

    • DOI

      10.1016/j.physbeh.2011.11.009

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Orexin contributes to feeding and drinking behaviour indeced by methamphetamine2014

    • Author(s)
      生駒葉子, 桑木共之, 大塚曜一郎
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島
    • Year and Date
      2014-03-17
    • Related Report
      2013 Final Research Report
  • [Presentation] THE CONTRIBUTION OF OREXIN SYSTEM TO INTEGRATED ULTRADIAN PHYSIOLOGICAL PATTERN2014

    • Author(s)
      Ootsuka Y, Miyata K, Ikoma Y, Kuwaki T, Yamanaka A
    • Organizer
      The 34th Annual Meeting of the Australasian Neuroscience Societ
    • Place of Presentation
      Adelaide, Australia
    • Year and Date
      2014-01-30
    • Related Report
      2013 Final Research Report
  • [Presentation] NVOLVEMENT OF OREXIN IN METHAMPHETAMINE- INDUCED HYPOPHAGIA AND HYPERACTIVITY2014

    • Author(s)
      Ikoma Y, Kuwaki T, Ootsuka Y
    • Organizer
      The 34th Annual Meeting of the Australasian Neuroscience Society
    • Place of Presentation
      Adelaide, Australia
    • Year and Date
      2014-01-29
    • Related Report
      2013 Final Research Report
  • [Presentation] Orexin contributes to feeding and drinking behaviour indeced by methamphetamine2014

    • Author(s)
      Ikoma Y, Kuwaki T and Ootsuka Y
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] THE CONTRIBUTION OF OREXIN SYSTEM TO INTEGRATED ULTRADIAN PHYSIOLOGICAL PATTERN2014

    • Author(s)
      Ootsuka Y, Miyata K, Ikoma Y, Kuwaki T, Yamanaka A.
    • Organizer
      he 34th Annual Meeting of the Australasian Neuroscience Society
    • Place of Presentation
      オーストラリア
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Rhythm of temperature and orexin2014

    • Author(s)
      Ootsuka Y
    • Organizer
      the 5th International Symposium on the Physiology and Pharmacology of Temperature Regulation
    • Place of Presentation
      南アフリカ
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] INVOLVEMENT OF OREXIN IN METHAMPHETAMINE-INDUCED HYPOPHAGIA AND HYPERACTIVITY2014

    • Author(s)
      Ikoma Y, Kuwaki T, Ootsuka Y.
    • Organizer
      he 34th Annual Meeting of the Australasian Neuroscience Society
    • Place of Presentation
      オーストラリア
    • Related Report
      2013 Annual Research Report
  • [Presentation] オレキシンニューロンに共存するグルタミン酸はストレス誘発性熱産生に重要である2013

    • Author(s)
      宮田紘平, 大塚曜一郎, 桑木共之
    • Organizer
      第90回日本生理学会
    • Place of Presentation
      東京
    • Year and Date
      2013-03-29
    • Related Report
      2013 Final Research Report
  • [Presentation] メタアンフェタミンー生理反応でのオレキシン共存伝達物質であるグルタミン酸の役割2013

    • Author(s)
      生駒葉子, 宮田紘平, 桑木共之, 大塚曜一郎
    • Organizer
      第90回日本生理学会
    • Place of Presentation
      東京
    • Year and Date
      2013-03-29
    • Related Report
      2013 Final Research Report
  • [Presentation] メタンフェタミン投与による自律生理反応でのオレキシン神経伝達物質グルタミン酸の役割2013

    • Author(s)
      生駒葉子, 宮田紘平, 桑木共之, 大塚曜一郎
    • Organizer
      第8回環境生理プレコングレス
    • Place of Presentation
      新宿
    • Year and Date
      2013-03-26
    • Related Report
      2013 Final Research Report
  • [Presentation] The Basic Rest- Activity Cycle (BRAC) is present in transgenic rats with ataxin3- mediated destruction of orexin neurones, but amplitude of the BRAC- associated brown adipose tissue and body temperature change are reduced2013

    • Author(s)
      Blessing WW, Mohammed M, Ootsuka Y
    • Organizer
      XXXVII International Congress of Physiological Sciences
    • Place of Presentation
      UK
    • Related Report
      2013 Final Research Report
  • [Presentation] A role of glutamate co- released from orexin neurons in methamphetamine- induced autonomic physiological response2013

    • Author(s)
      Ikoma Y, Kuwaki T, Ootsuka Y
    • Organizer
      XXXVII International Congress of Physiological Sciences
    • Place of Presentation
      Birmingham, UK
    • Related Report
      2013 Final Research Report
  • [Presentation] Transgenic Sprague Dawley rats with ataxin3- mediated destruction of orexin neurons display reduced tail artery Sympathetic Cutaneous Vasomotor Alerting Responses (SCVARs)2013

    • Author(s)
      Mohammed M, Ootsuka Y, Yanagisawa M, Blessing WW
    • Organizer
      XXXVII International Congress of Physiological Sciences
    • Place of Presentation
      Birmingham, UK
    • Related Report
      2013 Final Research Report
  • [Presentation] udden access to live cochroaches increases brown adipose tissue (BAT) thermogenesis in conscious unrestrained rats2013

    • Author(s)
      Blessing WW, Mohammed, M, Ootsuka Y
    • Organizer
      XXXVII International Congress of Physiological Sciences
    • Place of Presentation
      Birmingham, UK
    • Related Report
      2013 Final Research Report
  • [Presentation] The Basic Rest-Activity Cycle (BRAC) is present in transgenic rats with ataxin3-mediated destruction of orexin neurones, but amplitude of the BRAC-associated brown adipose tissue and body temperature change are reduced2013

    • Author(s)
      Blessing WW, Mohammed M and Ootsuka Y
    • Organizer
      XXXVII International Congress of Physiological Sciences
    • Place of Presentation
      イギリス
    • Related Report
      2013 Annual Research Report
  • [Presentation] A role of glutamate co-released from orexin neurons in methamphetamine-induced autonomic physiological response2013

    • Author(s)
      Ikoma Y, Kuwaki T, Ootsuka Y
    • Organizer
      XXXVII International Congress of Physiological Sciences
    • Place of Presentation
      イギリス
    • Related Report
      2013 Annual Research Report
  • [Presentation] Transgenic Sprague Dawley rats with ataxin3-mediated destruction of orexin neurons display reduced tail artery Sympathetic Cutaneous Vasomotor Alerting Responses (SCVARs)2013

    • Author(s)
      Mohammed M, Ootsuka Y, Yanagisawa M, Blessing WW
    • Organizer
      XXXVII International Congress of Physiological Sciences
    • Place of Presentation
      イギリス
    • Related Report
      2013 Annual Research Report
  • [Presentation] Sudden access to live cochroaches increases brown adipose tissue (BAT) thermogenesis in conscious unrestrained rats2013

    • Author(s)
      Blessing WW, Mohammed, M, Ootsuka Y
    • Organizer
      XXXVII International Congress of Physiological Sciences
    • Place of Presentation
      イギリス
    • Related Report
      2013 Annual Research Report
  • [Presentation] オレキシン機構はウルトラディアンリズムによる心拍数、活動量の一過性の増加に関与2013

    • Author(s)
      宮田紘平、大塚曜一郎、桑木共之
    • Organizer
      第90回日本生理学会
    • Place of Presentation
      船堀、東京
    • Related Report
      2012 Research-status Report
  • [Presentation] オレキシンニューロンに共存するグルタミン酸はストレス誘発性熱産生に重要である2013

    • Author(s)
      松元愛海、鮫島光平、窪凛太郎、川瀧正典、大塚曜一郎、桑木共之
    • Organizer
      第90回日本生理学会
    • Place of Presentation
      船堀、東京
    • Related Report
      2012 Research-status Report
  • [Presentation] メタアンフェタミンー生理反応でのオレキシン共存伝達物質であるグルタミン酸の役割2013

    • Author(s)
      生駒葉子、宮田紘平、桑木共之、大塚曜一郎
    • Organizer
      第90回日本生理学会
    • Place of Presentation
      船堀、東京
    • Related Report
      2012 Research-status Report
  • [Presentation] メタンフェタミン投与による自律生理反応でのオレキシン神経伝達物質グルタ ミン酸の役割2013

    • Author(s)
      生駒葉子、宮田紘平、桑木共之、大塚曜一郎
    • Organizer
      第8回環境生理プレコングレス
    • Place of Presentation
      新宿
    • Related Report
      2012 Research-status Report
  • [Presentation] Ultradian Basic Rest-Activity Cycle in orexin deficient mice2012

    • Author(s)
      Miyata K, Ootsuka Y, Kuwaki T
    • Organizer
      Neuroscience 2012 (Society for Neuroscience)
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2012-10-17
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] Application of latest gene-engineered mice to autonomic neuroscience research2012

    • Author(s)
      Ootsuka Y
    • Organizer
      Collaborators Day 2012
    • Place of Presentation
      Adelaide, Australia
    • Year and Date
      2012-09-28
    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Invited
  • [Presentation] 循環・呼吸・行動・摂食の超日リズムとオレキシン2012

    • Author(s)
      大塚曜一郎, 宮田紘平, 桑木共之
    • Organizer
      第19回日本時間生物学会学術大会
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-15
    • Related Report
      2013 Final Research Report
  • [Presentation] 睡眠・覚醒とエネルギー代謝の超日生体リズム2012

    • Author(s)
      大塚曜一郎
    • Organizer
      日本睡眠学会第37回定期学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2012-06-29
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Methamphetamine causes considerable bradycardia in orexin knockout mice2012

    • Author(s)
      宮田紘平, 大塚曜一郎, 桑木共之
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      長野
    • Year and Date
      2012-03-31
    • Related Report
      2013 Final Research Report
  • [Presentation] オレキシン欠損マウスでのメタアンフェタミンの心拍への効果2012

    • Author(s)
      大塚曜一郎, 宮田紘平, 桑木共之
    • Organizer
      第7回環境生理学プレコングレ
    • Place of Presentation
      長野
    • Year and Date
      2012-03-28
    • Related Report
      2013 Final Research Report
  • [Presentation] 睡眠・覚醒とエネルギー代謝の超日生体リズム2012

    • Author(s)
      大塚曜一郎
    • Organizer
      日本睡眠学会第37回定期学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 循環・呼吸・行動・摂食の超日リズムとオレキシン2012

    • Author(s)
      大塚曜一郎、宮田紘平、桑木共之
    • Organizer
      第19回日本時間生物学会学術大会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] オレキシン神経機構の超日リズム形成への関与2011

    • Author(s)
      宮田紘平, 大塚曜一郎, 桑木共之
    • Organizer
      第62回西日本生理学会大会
    • Place of Presentation
      佐賀
    • Year and Date
      2011-10-14
    • Related Report
      2013 Final Research Report
  • [Presentation] Ultradian 90 min biological rhythm is attenuated in orexin-deficient mice2011

    • Author(s)
      Ootsuka, Y., Miyata, T, Kuwaki, T.
    • Organizer
      Joint Meeting of 7th Congress of the International Society for Autonomic Neuroscience and 22nd Symposium of the American Autonomic Society AAS2011
    • Place of Presentation
      Bouzios, Brazil
    • Year and Date
      2011-09-15
    • Related Report
      2013 Final Research Report
  • [Presentation] Ultradian rhythmicity in autonomic and behavioural parameters2011

    • Author(s)
      Blessing W.W., Ootsuka, Y.
    • Organizer
      Joint Meeting of 7th Congress of the International Society for Autonomic Neuroscience and 22nd Symposium of the American Autonomic Society AAS2011
    • Place of Presentation
      Bouzios, Brazil
    • Year and Date
      2011-09-15
    • Related Report
      2013 Final Research Report
  • [Presentation] The role of orexin in autonomic physiological response elicited by methamphetamine in mice2011

    • Author(s)
      Ootsuka, Y., Miyata, T, Kuwaki, T
    • Organizer
      Satellite Symposium for Joint Meeting of 7th Congress of the International Society for Autonomic Neuroscience and 22nd Symposium of the American Autonomic Society AAS2011
    • Place of Presentation
      Ouro Preto, Brazil
    • Year and Date
      2011-09-13
    • Related Report
      2013 Final Research Report
  • [Presentation] 循環・体温の超日リズム2011

    • Author(s)
      大塚曜一郎
    • Organizer
      第10回九州脳と高血圧研究会
    • Place of Presentation
      福岡
    • Year and Date
      2011-07-16
    • Related Report
      2013 Final Research Report
  • [Presentation] 循環・体温の超日リズム

    • Author(s)
      大塚曜一郎
    • Organizer
      第10回九州脳と高血圧研究会
    • Place of Presentation
      福岡
    • Related Report
      2011 Research-status Report
  • [Presentation] Ultradian 90 min biological rhythm is attenuated in orexin-deficient mice

    • Author(s)
      Ootsuka, Y., Miyata, T, Kuwaki, T.
    • Organizer
      Joint Meeting of 7th Congress of the International Society for Autonomic Neuroscience and 22nd Symposium of the American Autonomic Society AAS2011
    • Place of Presentation
      ブラジル
    • Related Report
      2011 Research-status Report
  • [Presentation] The role of orexin in autonomic physiological response elicited by methamphetamine in mice

    • Author(s)
      Ootsuka, Y., Miyata, T, Kuwaki, T.
    • Organizer
      Satellite Symposium for Joint Meeting of 7th Congress of the International Society for Autonomic Neuroscience and 22nd Symposium of the American Autonomic Society AAS2011
    • Place of Presentation
      ブラジル
    • Related Report
      2011 Research-status Report
  • [Presentation] Ultradian rhythmicity in autonomic and behavioural parameters

    • Author(s)
      Blessing W.W., Ootsuka, Y.
    • Organizer
      Joint Meeting of 7th Congress of the International Society for Autonomic Neuroscience and 22nd Symposium of the American Autonomic Society AAS2011(招待講演)
    • Place of Presentation
      ブラジル
    • Related Report
      2011 Research-status Report
  • [Presentation] オレキシン神経機構の超日リズム形成への関与

    • Author(s)
      宮田紘平、大塚曜一郎、桑木共之
    • Organizer
      第62回西日本生理学会大会
    • Place of Presentation
      佐賀
    • Related Report
      2011 Research-status Report
  • [Presentation] 超日生体リズムはオレキシン欠損マウスで減弱する

    • Author(s)
      宮田紘平、大塚曜一郎、桑木共之
    • Organizer
      第38回自律神経研究会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] オレキシン欠損マウスでのメタアンフェタミンの心拍への効果

    • Author(s)
      大塚曜一郎、宮田紘平、桑木共之
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      長野
    • Related Report
      2011 Research-status Report
  • [Presentation] オレキシン欠損マウスの脳波、摂食、体温の超日生体リズム

    • Author(s)
      宮田紘平、大塚曜一郎、桑木共之
    • Organizer
      第7回環境生理学プレコングレス
    • Place of Presentation
      長野
    • Related Report
      2011 Research-status Report
  • [Presentation] 第89回日本生理学会大会

    • Author(s)
      宮田紘平、大塚曜一郎、桑木共之
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      長野
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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