| Project/Area Number |
23590282
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Jichi Medical University |
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Principal Investigator |
TORU Yokoyama 自治医科大学, 医学部, 助教 (80425321)
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| Co-Investigator(Kenkyū-buntansha) |
MINAMI Kouichiro 自治医科大学, 医学部, 講師 (70279347)
UETA Yoichi 産業医科大学, 医学部, 教授 (10232745)
UEZONO Yasuhito 国立がん研究センター, 研究所, 分野長 (20213340)
TERAWAKI Kiyoshi 国立がん研究センター, 研究所, ユニットリーダー (20572465)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | がん悪液質 / 電気生理学 / パッチクランプ / 体液調節 / バゾプレッシン / キスぺプチン / 電気生理 / シナプス / がん / 悪液質 / 行動生理学 |
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| Research Abstract |
Cancer cachexia (CC), a syndrome characterized by anorexia and body weight loss due to low fat-free mass levels, including reduced musculature, markedly worsens patient quality of life.
Body fluid balance may be changed by several conditions, such as anorexia, inflammation, dehydration and ascites in CC. Drinking behaviour and the release of arginine-vasopressin from the magnocellular neurosecretory cells in the supraoptic nucleus (SON) are crucial for body fluid homeostasis. We compared the reaction to osmotic pressure and angiotensin II of the CC model rat with the normal model rat in in vitro rat brain slice prepalation, using whole-cell patch-clamp recordings. Hyperosmotic stimulation and application of angiotensin II potentiate the frequency of miniature excitatory postsynaptic currents (mEPSCs) without affecting the amplitude in normal rats. However, this effect was attenuated in CC model rats. These results suggest that CC may change the sensation of mEPSCs in the SON.
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