| Project/Area Number |
23590283
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Toho University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | Circadian rhythm / Phosphorylation / Heat shock / Apoptosis / Anti-oxidant / Reactive oxygen species / Bioluminescence / stress / circadian rhythm / phosphorylation / heat shock / apoptosis / anti-oxidant / reactive oxygen species / bioluminescence / stress response / reactive oxygen spieces / oxidative stress / microarray / transcription factor / signal transduction / cancer / clock |
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| Research Abstract |
Circadian clock system integrates various physiological activities in whole body, and exhibits synchronizing properties as adaptive responses toward environments/ stresses. Thus, clock dysfunction become risk factors such for various lifestyle related diseases and cancer. This study examined time-specific and periodic regulatory system with CK2-orchestrated circadian protein phosphorylating oscillator. We elucidated circadian-oscillatory mechanism of CK2 activity and pivotal role of CK2 in integrating circadian system. Additionally, we found clock-synchronization by cell injury stresses, critical in disease processes, heat shock and reactive oxygen species, and integrative role of CK2 in the synergistic clock synchronization and the activation of stress-protective pathways, such as heat-shock response, anti-apoptotic and anti-oxidant pathways.
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