Establishment of systematic countermeasures for space deconditioning caused by spaceflight

• Project/Area Number: 23590288
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: Aichi Medical University
• Principal Investigator: NISHIMURA Naoki 愛知医科大学, 医学部, 講師 (40278362)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2013: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: 人工重力負荷＋運動負荷 / 模擬微小重力 / 宇宙デコンディショニング / 対抗措置 / 模擬宇宙環境暴露 / 人工重力負荷 / 自転車漕ぎ運動 / 下肢運動負荷 / 模擬宇宙環境実験 / 運動負荷

Outline of Final Research Achievements

We investigated that artificial gravity and ergometric exercise as the countermeasure throughout -6° head-down bed rest (HDBR) for 10 days prevent cardiovascular and bone metabolism deconditioning. During the HDBR, two subjects performed ergometric exercise with artificial gravity for cumulative 30 min per day (countermeasure:CM), while three subjects underwent the same HDBR procedure without countermeasure (control:CR). In CM group, reduction of orthostatic tolerance after HDBR has been suppressed whereas it decreased after HDBR in the CR group. However, urinary deoxypiridinorine (DPD) and crosslinked N-telopeptides of type I collagen (NTX) as an index of bone metabolism were not significant difference between CM and CR group. Therefore, it may be necessary to further improve our device. The final goal for our study is to validate the artificial gravity with ergometric exercise as a universal countermeasure to prevent the spaceflight deconditioning.

Research Products

• [Presentation] 短腕式遠心機による人工重力負荷の発生と運動負荷装置の宇宙デコンディショニングに対する効果 (2015)
  • Author(s): 西村直記，岩瀬 敏，田中邦彦，間野忠明
  • Organizer: 第29回宇宙環境利用シンポジウム
  • Place of Presentation: 宇宙航空研究開発機構
  • Year and Date: 2015-01-24 – 2015-01-25
• [Presentation] Effectiveness of an improved artificial gravity with ergometric exercise device (2013)
  • Author(s): Naoki Nishimura
  • Organizer: 29th International Symposium on Space Technology and Science
  • Place of Presentation: 名古屋国際センター
• [Presentation] Effectiveness of an improved artificial gravity with ergometric ecercise device as a countermeasure for spaceflignt deconditioning (2013)
  • Author(s): Naoki Nishimura, Iwase Satoshi, Kunihiko Tanaka, Tadaaki Mano
  • Organizer: 29th International symposium on Space Technology and Science
  • Place of Presentation: 名古屋国際会議場
• [Presentation] ISS内で運用可能な短腕式人工重力負荷装置の開発-AGREEプロジェクト- (2012)
  • Author(s): 西村直記、岩瀬敏、菅屋潤壹
  • Organizer: 第28回宇宙利用シンポジウム
  • Place of Presentation: 日本学術会議
• [Presentation] ISS内で運用可能な短腕式人工重力負荷装置の開発 (2011)
  • Author(s): 西村直記、岩瀬敏、菅屋潤壹
  • Organizer: 弟64回日本自律神経学会総会
  • Place of Presentation: 秋田ビューホテル