Study of natural resources improving the interaction between adipocytes and vascular endothelial cells
| Project/Area Number |
23590291
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Kinki University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUO Osamu 近畿大学, 医学部, 教授 (40030879)
OKADA Kiyotaka 近畿大学, 医学部, 講師 (20185432)
YAMASHITA Rina 近畿大学, 農学部, 助手 (90510876)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 脂肪細胞 / 血管内皮細胞 / 遊走 / 動脈硬化 / 肥満 / 天然資源物質 / 抗血栓性 / アントシアニン |
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| Research Abstract |
Obesity is caused by the accumulation of oil into adipocytes and the deterioration factor for atherosclerosis. Angiogenesis induced by the migration of vascular endothelial (VE) cells is involved in acceleration of atherosclerosis. On the other hand, VE cells contribute to prevention of thrombogenesis. In this study, the natural resources which affect the interaction between adipocytes and VE cells were investigated. As a result, it was clarified that cyanidin-3-glucoside, natural pigments from black soy beans, and the humic substance inhibited the migration of VE cells in the presence of adipocytes. Moreover, it was demonstrated that the humic substance suppressed the progression of atherosclerosis and induced anti-thrombotic effect in animal model.
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] Lack of both α2-antiplasmin and plasminogen activator inhibitor type-1 induces high IgE production2013
Author(s)
Okada K, Ueshima S, Kawao N, Yano M, Tamura Y, Tanaka M, Sakamoto A, Hatano M, Arima M, Miyata S, Nagai N, Tokuhisa T, and Matsuo O
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Journal Title
Life Sci
Volume: 93
Issue: 2-3
Pages: 89-95
DOI
Related Report
Peer Reviewed
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[Journal Article] Urokinase-type plasminogen activator and plasminogen mediate activation of macrophage phagocytosis during liver repair in vivo.2012
Author(s)
Kawao N, Nagai N, Tamura Y, Horiuchi Y, Okumoto K, Okada K, Suzuki Y, Umemura K, Yano M, Ueshima S, Kaji H, Matsuo O.
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Journal Title
Thromb Haemost
Volume: 107
Issue: 04
Pages: 749-59
DOI
Related Report
Peer Reviewed
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[Presentation] Management and assessment of preoperative pulmonary embolism in the japanese academic medical center.2011
Author(s)
Yasuda C, Taniguchi M, Akagi M, Okada K, Ueshima S, Matsuo O, Ishimaru E, Kajikawa R, Shiokawa Y, Takeyama Y, Okuno K, Shiozaki H.
Organizer
The XXIII Congress of the International Society on Thrombosis and Haemostasis
Place of Presentation
京都国際会議場（京都）
Related Report
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