| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Research Abstract |
The central chemosensitive respiratory regulation in medulla of brainstem is important in the maintenance of blood gas and pH homeostasis. We reported that transient receptor potential (TRP) channel family was involved in hypercapnic Ca responses in medullary glial cells. To identify the subtype of the TRP channels as central chemosensing molecules, we detected the expression pattern of TRP channel family in medullary glial cells. TRP-X subtype channel is highest expression in medullary glial cells. In comparison with wild-type mice, the effects of ventilation response to 8%CO2 on TRP-X knockout mice attenuated. These results suggest that the TRP-X channel is involved in the central chemosensitive respiratory regulation.
|
