| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
We indicated that the exposure of nicotine had changed the human vascular smooth muscle cells (HSMCs) phenotype from contractile-type to a synthetic-like type by the results of the exhaustive gene expression profiling analysis. When the HSMCs were de-differentiated into synthetic phenotype, their migration increases, which might be the result of enhanced activation of MAPKs. We propose that nicotine directly may promote the migration of HSMCs from the tunica media to atheromatous plaques in the vascular intima. We have identified a microRNA that varies in accordance with the de-differentiation of the HSMCs.
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