| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
This study showed that (1) RGS2 and spinophilin (SPL) are present in vascular smooth muscle cells, (2) RGS2 showed potent inhibitory effects on intracellular calcium responses induced by Ang II in HEK293T cells stably expressing AT1 receptors, (3) SPL strongly enhanced the inhibitory effects of RGS2 on AT1 receptor calcium signaling, and (4) estrogen increased the expression of SPL in vascular smooth muscle cells. These results strongly suggests that loss of circulating estrogen in blood decreases the expression of SPL in smooth muscle cells, and the decreased expression of SPL weakens the inhibitory effects of RGS2 enhanced by SPL, leading to the development of hypertension in postmenopausal women.
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