Analysis of sex differences in cardiovascular development
| Project/Area Number |
23590297
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
KUROKAWA Junko 東京医科歯科大学, 難治疾患研究所, 准教授 (40396982)
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| Co-Investigator(Renkei-kenkyūsha) |
西山 功 熊本大学, 付属病院, 特任講師 (80398221)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 循環器 / 性差 / 心臓 / 発生 / 冠血管 / マウス / 発現解析 / 不整脈 / 再生 |
|---|
| Research Abstract |
Cardiovascular disease (CVD) affects men at younger age than women, which has been attributed to the loss of estrogen after menopause. However, recent clinical and basic studies unravel that the underlying mechanisms seem unlikely to be due to estrogen only and are more complex. Although it is well established that aging is a risk factor for CVDs, many of the molecular pathways involved in CVDs have roots in cardiac developmental programs. Thus, we here seek biological sex differences in cardiovascular development of murine hearts to obtain clues to elucidate the sex differences in CVDs. We found sex differences in morphological and physiological functions of coronary arteries in murine hearts at embryonic day 17.5, and the differece was abolished by vasodilators. These results suggest that sex differences in coronary arteries exist at a late embryonic stage in mice.
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Report
(4 results)
Research Products
(94 results)
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[Journal Article] Effects of an hERG Activator, ICA-105574, on Electrophysiological Properties of Canine Hearts2013
Author(s)
Asayama M, Kurokawa J, Shirakawa K, Okuyama H, Kagawa T, Okada J, Sugiura S, Hisada T, Furukawa T.
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Journal Title
Journal of Pharmacological Sciences
Volume: 121
Issue: 1
Pages: 1-8
DOI
NAID
ISSN
1347-8613, 1347-8648
Related Report
Peer Reviewed
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[Journal Article] Circulating KCNH2 Current-Activating Factor in Patients with Heart Failure and Ventricular Tachyarrhythmia2011
Author(s)
Sugiyama H, Nakamura K, Morita H, Akagi S, Tani Y, Katayama Y, Nishii N, Miyoshi T, Nagase S, Kohno K, Kusano KF, Ohe T, Kurokawa J, Furukawa T, Ito H
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Journal Title
PLoS One
Volume: 6
Issue: 5
Pages: e19897-e19897
DOI
Related Report
Peer Reviewed
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[Presentation] 第87回日本薬理学会大会2014
Author(s)
Li M, Kanda Y, Ashihara T, Sekino Y, Furukawa T, Kurokawa J
Organizer
第87回日本薬理学会大会
Place of Presentation
宮城，仙台国際センター
Related Report
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[Presentation] Contractile behaviors of human-induced pluripotent stem cell-derived cardiomyocyte monolayers evaluated with an image-based analysis using motion vector prediction technique: A comparison with extracellular electrophysiology.2013
Author(s)
Hayakawa T, Kunihiro T, Ando T, Unno H, Kobayashi S, Matsui E, Yada H, Kanda Y, Kurokawa J, Furukawa T.
Organizer
13th annual meeting of Safety Pharmacology Society.
Place of Presentation
Rotterdam, Netherlands
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