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Role of neuronal PAS domain 4 (Npas4) in psychiatric disorder.

Research Project

Project/Area Number 23590299
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General pharmacology
Research InstitutionNagoya University

Principal Investigator

HIBI YOKO  名古屋大学, 医学部附属病院, 特任助教 (70295616)

Co-Investigator(Kenkyū-buntansha) YAMADA Kiyofumi  名古屋大学, 医学部附属病院, 教授 (30303639)
Co-Investigator(Renkei-kenkyūsha) NAGAI Taku  名古屋大学, 医学部附属病院, 准教授 (10377426)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsストレス / Npas4 / 転写制御 / グルココルチコイド / プロモーター / DNAメチル化 / NPAS4 / stress / glucocorticoid / promoter
Research Abstract

Neuronal PAS domain 4 (NPAS4) has recently been shown to regulate the development of GABAergic inhibitory synapses. We previously reported that Npas4 mRNA expression levels were reduced in the hippocampus of mice exposed to social isolation or restraint stress. In the present study, to investigate the transcriptional regulation of Npas4 by stress, we focused on the effect of glucocorticoids upon Npas4 transcription. Corticosterone treatment reduced Npas4 expression in the frontal cortex and hippocampus. Putative negative glucocorticoid response elements (GREs) were found -2000 to -1000 upstream of the Npas4 transcription initiation site. Npas4 promoter activity was increased by mutation of the negative GRE sequences. Restraint stress increased the binding of GR to Npas4 promoter region in the hippocampus. These results suggest that transcription of Npas4 is down-regulated by stress via the binding of agonist-bound GR to its promoter.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (57 results)

All 2014 2013 2012 2011 Other

All Journal Article (27 results) (of which Peer Reviewed: 25 results,  Open Access: 2 results) Presentation (30 results)

  • [Journal Article] Overexpression of Shati/Nat8l, an N-acetyltransferase, in the nucleus accumbens attenuates the response to methamphetamine via activation of group II mGluRs in mice2014

    • Author(s)
      Miyamoto Y., Ishikawa Y., Iegaki N., Furukawa- Hibi Y., Nabeshima T., Uno K., Nitta A.(他4名)
    • Journal Title

      Int. J . Neuropsychopharmacol

      Pages: 1-12

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Deletion of SHATI/NAT8L increases dopamine D1 receptor on the cell surface in the nucleus accumbens, accelerating methamphetamine dependence2014

    • Author(s)
      Toriumi K., Kondo M., Nagai T., Furukawa-Hibi Y., Mamiya T., Fukushima T., Takeda M., Nitta A., Yamada K., Nabeshima T.(他7名)
    • Journal Title

      Int. J . Neuropsychopharmacol

      Volume: 17 Pages: 443-452

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of Shati/Nat8l, an N-acetyltransferase, in the nucleus accumbens attenuates the response to methamphetamine via activation of group II mGluRs in mice2014

    • Author(s)
      Miyamoto Y., Ishikawa Y., Iegaki N., Sumi K., Fu K., Sato K., Furukawa-Hibi Y., Muramatsu S., Nabeshima T., Uno K., Nitta A.
    • Journal Title

      Int. J. Neuropsychopharmacol.

      Volume: 17 Issue: 08 Pages: 1-12

    • DOI

      10.1017/s146114571400011x

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Deletion of SHATI/NAT8L increases dopamine D1 receptor on the cell surface in the nucleus accumbens, accelerating methamphetamine dependence2014

    • Author(s)
      Toriumi K, Kondo M, Nagai T, Hashimoto R, Ohi K, Song Z, Tanaka J, Mouri A, Koseki T, Yamamori H, Furukawa-Hibi Y, Mamiya T, Fukushima T, Takeda M, Nitta A, Yamada K, Nabeshima T
    • Journal Title

      Int J Neuropsychopharmacol

      Volume: 17 Issue: 03 Pages: 443-453

    • DOI

      10.1017/s1461145713001302

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] SHATI/NAT8L regulates neurite outgrowth via microtubule stabilization2014

    • Author(s)
      K Toriumi, M Ikami, M Kondo, A Mouri, T Koseki, D Ibi, Y Furukawa-Hibi, T Nagai, T Mamiya, A Nitta, K Yamada and T Nabeshima
    • Journal Title

      Journal of Neuroscience Research

      Volume: 91 Issue: 12 Pages: 1525-1532

    • DOI

      10.1002/jnr.23273

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Correlation of CYP2C19 Phenotype with Voriconazole Plasma Concentration in Children2013

    • Author(s)
      Narita A., Muramatsu H., Sakaguchi H., Furukawa-Hibi Y., Yamada K. and Kojima S.(他9名)
    • Journal Title

      J . Pediat. Hematol. Onc

      Volume: 35(5)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] SHATI/NAT8L regulates neurite outgrowth via microtubule stabilization2013

    • Author(s)
      Toriumi K., Ikami M., Furukawa-Hibi Y., Nagai T., Mamiya T., Nitta A., Yamada K. and Nabeshima T.(他3名)
    • Journal Title

      J . Neurosci. Res

      Volume: 91 Pages: 1525-1532

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neuronal PAS domain protein 4 (Npas4) regulates neurite outgrowth and phosphorylation of synapsin I2013

    • Author(s)
      Yun, J., Nagai, T., Furukawa-Hibi, Y., Kuroda, K., Kaibuchi, K. and Yamada, K.
    • Journal Title

      J . Biol. Chem

      Volume: 288 Pages: 2655-2664

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] アルツハイマー型認知症治療薬について2013

    • Author(s)
      日比陽子
    • Journal Title

      ファルマシア

      Volume: 49(6) Pages: 539-543

    • NAID

      110010010583

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neuronal PAS domain domain protein 4 (Npas4) regulates neurite outgrowth and phosphorylation of synapsin I.2013

    • Author(s)
      Yun J, Nagai T, Furukawa-Hibi Y, Kuroda K, Kaibuchi K, Greenberg ME, and Yamada K
    • Journal Title

      J. Biol. Chem.

      Volume: 288 Issue: 4 Pages: 2655-2664

    • DOI

      10.1074/jbc.m112.413310

    • Related Report
      2013 Annual Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Transcriptional suppression of the neuronal PAS domain 4 (Npas4) gene by stress via the binding of agonist-bound glucocorticoid receptor to its promoter2012

    • Author(s)
      Furukawa-Hibi, Y., Yun, J., Nagai, T. and Yamada, K.
    • Journal Title

      J . Neurochem

      Volume: 123 Pages: 866-875

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Absence of SHATI/Nat8l reduces social interaction in mice2012

    • Author(s)
      Furukawa-Hibi, Y., Nitta, A., Furukawa, S., Nabeshima, T. and Yamada, K.(他3名)
    • Journal Title

      Neurosci. Lett

      Volume: 526 Pages: 79-84

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Somatic mosaicism for oncogenic NRAS mutations in juvenile myelomonocytic leukemia2012

    • Author(s)
      Doisaki, S., Muramatsu, H., Shimada, A., Furukawa-Hibi, Y., Yamada, K., Tanaka, M., Hama, A., Koike, K. and Kojima, S.(他16名)
    • Journal Title

      Blood

      Volume: 120(7) Pages: 1485-1488

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Using peripheral blood circulating DNAs to detect CpG global methylation status and genetic mutations in patients with myelodysplastic syndrome2012

    • Author(s)
      Iriyama, C., Tomita, A., Furukawa-Hibi, Y., Yamada, K., Kiyoi, H., Naoe, T.(他2名)
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 419(4) Pages: 662-669

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 神経系におけるブチリルコリンエステラーゼの機能2012

    • Author(s)
      日比陽子, 山田清文
    • Journal Title

      Clinical Neuroscience

      Volume: 30(6) Pages: 672-674

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] ストレスにより誘発される脳機能障害とストレス応答性転写因子Npas4の機能解析2012

    • Author(s)
      永井拓, 尹在錫, 衣斐大祐, 小池宏幸, 日比陽子, 山田清文
    • Journal Title

      日本薬理学雑誌

      Volume: 139 Pages: 147-151

    • NAID

      10030572362

    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Journal Article] Transcriptional suppression of the neuronal PAS domain 4 (Npas4) gene by stress via the binding of agonist-bound glucocorticoid receptor to its promoter2012

    • Author(s)
      Furukawa-Hibi Y, Yun J, Nagai T, and Yamada K
    • Journal Title

      J Neurochem

      Volume: 123 Issue: 5 Pages: 866-875

    • DOI

      10.1111/jnc.12034

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Absence of SHATI/Nat8l reduces social interaction in mice.2012

    • Author(s)
      Furukawa-Hibi Y, Nitta A, Fukumitsu H, Somiya H, Toriumi K, Furukawa S, Nabeshima T, Yamada K.
    • Journal Title

      Neurosci Lett.

      Volume: 526 Issue: 2 Pages: 79-84

    • DOI

      10.1016/j.neulet.2012.08.028

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Somatic mosaicism for oncogenic NRAS mutations in juvenile myelomonocytic leukemia2012

    • Author(s)
      Doisaki S, Muramatsu H, Shimada A, Takahashi Y, Mori-Ezaki M, Sato M, Kawaguchi H, Kinoshita A, Sotomatsu M, Hayashi Y, Furukawa-Hibi Y, Yamada K, Hoshino H, Kiyoi H, Yoshida N, Sakaguchi H, Narita A, Wang X, Ismael O, Xu Y, Nishio N, Tanaka M, Hama A, Koike K, Kojima S
    • Journal Title

      Blood

      Volume: 120 Issue: 7 Pages: 1485-1488

    • DOI

      10.1182/blood-2012-02-406090

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Using peripheral blood circulating DNAs to detect CpG global methylation status and genetic mutations in patients with myelodysplastic syndrome2012

    • Author(s)
      Chisako Iriyama
    • Journal Title

      Biochem Biophys Res Commun

      Volume: (in press) Issue: 4 Pages: 662-669

    • DOI

      10.1016/j.bbrc.2012.02.071

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 神経系におけるブチリルコリンエステラーゼの機能2012

    • Author(s)
      日比陽子、山田清文
    • Journal Title

      Clinical Neuroscience

      Volume: 30 Pages: 672-674

    • Related Report
      2012 Research-status Report
  • [Journal Article] Periocular injection of in situ hydrogels containing Leu-Ile, an inducer for neurotrophic factors, promotes retinal ganglion cell survival after optic nerve injury2011

    • Author(s)
      Nakatani, M., Shinohara, Y., Furukawa-Hibi, Y., Miyamoto, Y., Nitta, A.(他4名)
    • Journal Title

      Experimental Eye Research

      Volume: 96(6) Pages: 873-879

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Butyrylcholinesterase inhibitors ameliorate cognitive dysfunction induced by amyloid-βpeptide in mice2011

    • Author(s)
      Furukawa-Hibi, Y., Alkam T., Nitta, A., Nagai, T. and Yamada, K.(他6名)
    • Journal Title

      Behavioural Brain Research

      Volume: 225 Pages: 222-229

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The hydrophobic dipeptide Leu-Ile inhibits immobility induced by repeated forced swimming via the induction of BDNF2011

    • Author(s)
      Furukawa-Hibi, Y., Nitta, A., Ikeda, T., Nabeshima, T., and Yamada, K.(他4名)
    • Journal Title

      Behavioural Brain Research

      Volume: 220 Pages: 271-280

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] ストレスによる精神疾患の発症にDNAメチル化が関与する2011

    • Author(s)
      日比陽子
    • Journal Title

      ファルマシア

      Volume: 47(7) Pages: 663-664

    • NAID

      110009900999

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The hydrophobic dipeptide Leu-Ile inhibits immobility induced by repeated forced swimming via the induction of BDNF.2011

    • Author(s)
      Furukawa-Hibi, Y., Nitta, A., Ikeda, T., Morishita, K., Liu W, Ibi D., Alkam, T., Nabeshima, T., and Yamada, K.
    • Journal Title

      Behavioural Brain Research

      Volume: 220 Pages: 271-280

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Butyrylcholinesterase inhibitors ameliorate cognitive dysfunction induced by amyloid-β peptide in mice.2011

    • Author(s)
      Furukawa-Hibi, Y., Alkam T., Nitta, A., Matsuyama, A., Mizoguchi, H., Suzuki, K., Moussaoui, S., Yu, Q-S., Greig, N., Nagai, T. and Yamada, K.
    • Journal Title

      Behavioural Brain Research

      Volume: 225 Pages: 222-229

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 脳特異的転写因子Npas4欠損マウスにおける異常行動とGABA作動性神経系マーカーの変化2013

    • Author(s)
      日比(古川)陽子, 横井順平, 永井拓, 山田清文
    • Organizer
      第123回日本薬理学会近畿部会
    • Place of Presentation
      愛知県名古屋市愛知県産業労働センター
    • Year and Date
      2013-07-12
    • Related Report
      2013 Final Research Report
  • [Presentation] 長期ストレスはGABA神経関連転写因子Npas4遺伝子のDNAメチル化を亢進するChronic stress increases DNA methylation of Neuronal PAS domain 4 (Npas4)2013

    • Author(s)
      日比(古川)陽子, 永井拓, 山田清文
    • Organizer
      第23回日本臨床精神神経薬理学会・第43回日本神経精神薬理学会合同年会
    • Place of Presentation
      沖縄県宜野湾市沖縄コンベンションセンター
    • Related Report
      2013 Final Research Report
  • [Presentation] Transcriptional suppression of the neuronal PAS domain 4 (Npas4) gene by stress via glucocorticoid receptor in the brain2013

    • Author(s)
      Yoko Hibi, Jaesuk Yun, Taku Nagai, Kiyofumi Yamada
    • Organizer
      11th WFSBP
    • Place of Presentation
      京都府京都市京都国際会館
    • Related Report
      2013 Final Research Report
  • [Presentation] グルココルチコイド受容体は神経分化関連因子NPAS4の転写を直接抑制するDirect transcriptional regulation of neuronal transcription factor Npas4 by glucocorticoid receptor2013

    • Author(s)
      Yoko Hibi, Jaesuk Yun, Taku Nagai, Kiyofumi Yamada
    • Organizer
      第86回日本薬理学会
    • Place of Presentation
      福岡県博多市福岡国際会議場
    • Related Report
      2013 Final Research Report
  • [Presentation] Transcriptional suppression of the neuronal PAS domain 4 (Npas4) gene by stress via glucocorticoid receptor in the brain2013

    • Author(s)
      Yoko Hibi, Jaesuk Yun, Taku Nagai, and Kiyofumi Yamada
    • Organizer
      11th WFSBP
    • Place of Presentation
      京都市 京都国際会議場
    • Related Report
      2013 Annual Research Report
  • [Presentation] 長期ストレスはGABA神経関連転写因子Npas4遺伝子のDNAメチル化を亢進する Chronic stress increases DNA methylation of Neuronal PAS domain 4 (Npas4)2013

    • Author(s)
      日比(古川) 陽子、永井 拓、山田 清文
    • Organizer
      第23回日本臨床精神神経薬理学会・第43回日本神経精神薬理学会合同年会
    • Place of Presentation
      宜野湾市 沖縄コンベンションセンター
    • Related Report
      2013 Annual Research Report
  • [Presentation] グルココルチコイド受容体は神経分化関連因子NPAS4の転写を直接抑制する Direct transcriptional regulation of neuronal transcription factor Npas4 by glucocorticoid receptor2013

    • Author(s)
      Yoko Hibi, Jaesuk Yun, Taku Nagai, and Kiyofumi Yamada
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Related Report
      2012 Research-status Report
  • [Presentation] Glucocorticoid reduces the gene expression of neuronal PAS domain 4 (Npas4) in the brain2012

    • Author(s)
      Yoko Hibi, Jaesuk Yun, Taku Nagai, Kiyofumi Yamada
    • Organizer
      ASCB2012
    • Place of Presentation
      USAサンフランシスコ
    • Related Report
      2013 Final Research Report
  • [Presentation] Stress regulates the gene expression of neuronal transcription factor Npas4 via glucocorticoid2012

    • Author(s)
      Yoko Hibi, Jaesuk Yun, Taku Nagai, Kiyofumi Yamada
    • Organizer
      第4回GCOE国際シンポジウム
    • Place of Presentation
      愛知県名古屋市ウエスティンナゴヤキャッスルホテル
    • Related Report
      2013 Final Research Report
  • [Presentation] Transcriptional regulation of neuronal PAS domain 4 (NPAS4) by glucocorticoid receptor2012

    • Author(s)
      Yoko Hibi, Jaesuk Yun, Taku Nagai, Kiyofumi Yamada
    • Organizer
      The 11th APSN,The 55th J SN(日本神経化学会)
    • Place of Presentation
      兵庫県神戸市神戸国際会議場
    • Related Report
      2013 Final Research Report
  • [Presentation] Stress regulates the gene expression of neuronal PAS domain 4 (Npas4), via glucocorticoid receptor2012

    • Author(s)
      Yoko Hibi, Jaesuk Yun, Taku Nagai, Kiyofumi Yamada
    • Organizer
      CINP 2012
    • Place of Presentation
      スウェーデンストックホルム
    • Related Report
      2013 Final Research Report
  • [Presentation] グルココルチコイドによる転写因子NPAS4の発現抑制機構Glucocorticoid regulates the expression of neuronal PAS domain 4 (Npas4)2012

    • Author(s)
      日比陽子, ユンジェスク, 永井拓, 山田清文
    • Organizer
      第7回統合失調症学会
    • Place of Presentation
      愛知県名古屋市愛知県産業労働センター
    • Related Report
      2013 Final Research Report
  • [Presentation] ブチリルコリンエステラーゼ阻害剤のアミロイドベータ誘発性認知機能障害改善効果Butyrylcholinesterase inhibitors ameliorate cognitive dysfunction induced by amyloid-β peptide in mice2012

    • Author(s)
      日比(古川)陽子, アルカム・トルソン, 新田淳美, 松山明裕, 永井拓, 山田清文
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都府京都市京都国際会館
    • Related Report
      2013 Final Research Report
  • [Presentation] Stress regulates the gene expression of neuronal PAS domain 4 (Npas4), via glucocorticoid receptor2012

    • Author(s)
      Yoko Hibi, Jaesuk Yun, Taku Nagai, and Kiyofumi Yamada
    • Organizer
      CINP 2012
    • Place of Presentation
      ストックホルム スウェーデン
    • Related Report
      2012 Research-status Report
  • [Presentation] Transcriptional regulation of neuronal PAS domain 4 (NPAS4) by glucocorticoid receptor2012

    • Author(s)
      Yoko Hibi, Jaesuk Yun, Taku Nagai, and Kiyofumi Yamada
    • Organizer
      The 11th APSN The 55th JSN(日本神経化学会)
    • Place of Presentation
      神戸国際会議場(兵庫)
    • Related Report
      2012 Research-status Report
  • [Presentation] Stress regulates the gene expression of neuronal transcription factor Npas4 via glucocorticoid2012

    • Author(s)
      Yoko Hibi, Jaesuk Yun, Taku Nagai, and Kiyofumi Yamada
    • Organizer
      第4回GCOE国際シンポジウム
    • Place of Presentation
      名古屋キャッスルホテル(愛知)
    • Related Report
      2012 Research-status Report
  • [Presentation] Glucocorticoid reduces the gene expression of neuronal PAS domain 4 (Npas4) in the brain2012

    • Author(s)
      Yoko Hibi, Jaesuk Yun, Taku Nagai, and Kiyofumi Yamada
    • Organizer
      ASCB2012
    • Place of Presentation
      サンフランシスコ USA
    • Related Report
      2012 Research-status Report
  • [Presentation] 神経発達関連転写因子NPAS4のストレスによる転写抑制機構の解明2011

    • Author(s)
      日比(古川)陽子, ユンジェスク, 永井拓, 山田清文
    • Organizer
      第119回日本薬理学会近畿部会
    • Place of Presentation
      愛知県名古屋市愛知県産業労働センター
    • Year and Date
      2011-07-08
    • Related Report
      2013 Final Research Report
  • [Presentation] 神経発達関連転写因子NPAS4の発現調節機構の解明2011

    • Author(s)
      日比(古川)陽子, ユンジェスク, 永井拓, 山田清文
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      神奈川県横浜市パシフィコ横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] Stress reduces the expression of transcription factor, neuronal PAS domain 4 (NPAS4)2011

    • Author(s)
      Yoko Hibi, Jaesuk Yun, Taku Nagai, Kiyofumi Yamada
    • Organizer
      AsCNP2011
    • Place of Presentation
      韓国ソウル市
    • Related Report
      2013 Final Research Report
  • [Presentation] ストレスによるneuronal PAS domain 4 (NPAS4)の転写制御Transcriptional regulation of neuronal PAS domain 4 (NPAS4) by stress2011

    • Author(s)
      Yoko Hibi, Jaesuk Yun, Taku Nagai, Kiyofumi Yamada
    • Organizer
      Neuroscience 2011
    • Place of Presentation
      神奈川県横浜市パシフィコ横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] 脳特異的転写因子Npas4欠損マウスにおける異常行動とGABA作動性神経系マーカーの変化

    • Author(s)
      日比(古川) 陽子、横井 順平、永井 拓、山田 清文
    • Organizer
      第123回日本薬理学会近畿部会
    • Place of Presentation
      名古屋市 ウインク愛知
    • Related Report
      2013 Annual Research Report
  • [Presentation] 神経発達関連転写因子NPAS4のストレスによる転写抑制機構の解明

    • Author(s)
      日比(古川)陽子、ユン ジェスク、永井 拓、 山田 清文
    • Organizer
      第119回日本薬理学会近畿部会
    • Place of Presentation
      名古屋 愛知県産業労働センター
    • Related Report
      2011 Research-status Report
  • [Presentation] Transcriptional regulation of neuronal PAS domain 4 (NPAS4) by stress ストレスによるneuronal PAS domain 4 (NPAS4)の転写制御

    • Author(s)
      Yoko Hibi, Jaesuk Yun, Taku Nagai, Kiyofumi Yamada
    • Organizer
      Neuroscience 2011
    • Place of Presentation
      横浜  パシフィコ横浜
    • Related Report
      2011 Research-status Report
  • [Presentation] Stress reduces the expression of transcription factor, neuronal PAS domain 4 (NPAS4)

    • Author(s)
      Yoko Hibi, Jaesuk Yun, Taku Nagai and Kiyofumi Yamada
    • Organizer
      AsCNP
    • Place of Presentation
      韓国 ソウル
    • Related Report
      2011 Research-status Report
  • [Presentation] 神経発達関連転写因子NPAS4の発現調節機構の解明

    • Author(s)
      日比(古川)陽子、ユン ジェスク、永井 拓、 山田 清文
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      国立京都国際会館・グランドプリンスホテル京都
    • Related Report
      2011 Research-status Report
  • [Presentation] グルココルチコイドによる転写因子NPAS4の発現抑制機構 Glucocorticoid regulates the expression of neuronal PAS domain 4 (Npas4).

    • Author(s)
      日比 陽子、ユン ジェスク、永井 拓、山田 清文
    • Organizer
      第7回統合失調症学会
    • Place of Presentation
      名古屋 愛知県産業労働センター
    • Related Report
      2011 Research-status Report
  • [Presentation] Npas4 regulates neurite outgrowth and phosphoryation of synapsin I

    • Author(s)
      Jaesuk Yun, Taku Nagai, Yoko Hibi, Keisuke Kuroda, Kozo Kaibuchi, Kiyofumi Yamada
    • Organizer
      Neuroscience 2011
    • Place of Presentation
      横浜  パシフィコ横浜
    • Related Report
      2011 Research-status Report
  • [Presentation] The Role of Npas4 in Neurite Outgrowth and phosphorylation of Synapsin I

    • Author(s)
      Jaesuk Yun, Taku Nagai, Yoko Hibi, Keisuke Kuroda, Kozo Kaibuchi, Kiyofumi Yamada
    • Organizer
      AsCNP
    • Place of Presentation
      韓国 ソウル
    • Related Report
      2011 Research-status Report
  • [Presentation] Methamphetamine-induced Npas4; possible role in neurite outgrowth and p-synapsin I expression

    • Author(s)
      Yun Jaesuk, Nagai Taku, Hibi Yoko, Kuroda Keisuke, Kaibuchi Kozo,Yamada Kiyofumi
    • Organizer
      平成23年度アルコール・薬物依存関連学会合同学術総会
    • Place of Presentation
      名古屋 愛知県産業労働センター
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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