Role of neuronal PAS domain 4 (Npas4) in psychiatric disorder.

• Project/Area Number: 23590299
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General pharmacology
• Research Institution: Nagoya University
• Principal Investigator: HIBI YOKO 名古屋大学, 医学部附属病院, 特任助教 (70295616)
• Co-Investigator(Kenkyū-buntansha): YAMADA Kiyofumi 名古屋大学, 医学部附属病院, 教授 (30303639)
• Co-Investigator(Renkei-kenkyūsha): NAGAI Taku 名古屋大学, 医学部附属病院, 准教授 (10377426)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: ストレス / Npas4 / 転写制御 / グルココルチコイド / プロモーター / DNAメチル化 / NPAS4 / stress / glucocorticoid / promoter

Research Abstract

Neuronal PAS domain 4 (NPAS4) has recently been shown to regulate the development of GABAergic inhibitory synapses. We previously reported that Npas4 mRNA expression levels were reduced in the hippocampus of mice exposed to social isolation or restraint stress. In the present study, to investigate the transcriptional regulation of Npas4 by stress, we focused on the effect of glucocorticoids upon Npas4 transcription. Corticosterone treatment reduced Npas4 expression in the frontal cortex and hippocampus. Putative negative glucocorticoid response elements (GREs) were found -2000 to -1000 upstream of the Npas4 transcription initiation site. Npas4 promoter activity was increased by mutation of the negative GRE sequences. Restraint stress increased the binding of GR to Npas4 promoter region in the hippocampus. These results suggest that transcription of Npas4 is down-regulated by stress via the binding of agonist-bound GR to its promoter.

Research Products

• [Journal Article] Overexpression of Shati/Nat8l, an N-acetyltransferase, in the nucleus accumbens attenuates the response to methamphetamine via activation of group II mGluRs in mice (2014)
  • Author(s): Miyamoto Y., Ishikawa Y., Iegaki N., Furukawa- Hibi Y., Nabeshima T., Uno K., Nitta A.(他4名)
  • Journal Title: Int. J . Neuropsychopharmacol Pages: 1-12
  • Peer Reviewed
• [Journal Article] Deletion of SHATI/NAT8L increases dopamine D1 receptor on the cell surface in the nucleus accumbens, accelerating methamphetamine dependence (2014)
  • Author(s): Toriumi K., Kondo M., Nagai T., Furukawa-Hibi Y., Mamiya T., Fukushima T., Takeda M., Nitta A., Yamada K., Nabeshima T.(他7名)
  • Journal Title: Int. J . Neuropsychopharmacol Volume: 17 Pages: 443-452
  • Peer Reviewed
• [Journal Article] Overexpression of Shati/Nat8l, an N-acetyltransferase, in the nucleus accumbens attenuates the response to methamphetamine via activation of group II mGluRs in mice (2014)
  • Author(s): Miyamoto Y., Ishikawa Y., Iegaki N., Sumi K., Fu K., Sato K., Furukawa-Hibi Y., Muramatsu S., Nabeshima T., Uno K., Nitta A.
  • Journal Title: Int. J. Neuropsychopharmacol. Volume: 17 Issue: 08 Pages: 1-12
  • DOI: 10.1017/s146114571400011x
  • Peer Reviewed / Open Access
• [Journal Article] Deletion of SHATI/NAT8L increases dopamine D1 receptor on the cell surface in the nucleus accumbens, accelerating methamphetamine dependence (2014)
  • Author(s): Toriumi K, Kondo M, Nagai T, Hashimoto R, Ohi K, Song Z, Tanaka J, Mouri A, Koseki T, Yamamori H, Furukawa-Hibi Y, Mamiya T, Fukushima T, Takeda M, Nitta A, Yamada K, Nabeshima T
  • Journal Title: Int J Neuropsychopharmacol Volume: 17 Issue: 03 Pages: 443-453
  • DOI: 10.1017/s1461145713001302
  • Peer Reviewed / Open Access
• [Journal Article] SHATI/NAT8L regulates neurite outgrowth via microtubule stabilization (2014)
  • Author(s): K Toriumi, M Ikami, M Kondo, A Mouri, T Koseki, D Ibi, Y Furukawa-Hibi, T Nagai, T Mamiya, A Nitta, K Yamada and T Nabeshima
  • Journal Title: Journal of Neuroscience Research Volume: 91 Issue: 12 Pages: 1525-1532
  • DOI: 10.1002/jnr.23273
  • Peer Reviewed
• [Journal Article] Correlation of CYP2C19 Phenotype with Voriconazole Plasma Concentration in Children (2013)
  • Author(s): Narita A., Muramatsu H., Sakaguchi H., Furukawa-Hibi Y., Yamada K. and Kojima S.(他9名)
  • Journal Title: J . Pediat. Hematol. Onc Volume: 35(5)
  • Peer Reviewed
• [Journal Article] SHATI/NAT8L regulates neurite outgrowth via microtubule stabilization (2013)
  • Author(s): Toriumi K., Ikami M., Furukawa-Hibi Y., Nagai T., Mamiya T., Nitta A., Yamada K. and Nabeshima T.(他3名)
  • Journal Title: J . Neurosci. Res Volume: 91 Pages: 1525-1532
  • Peer Reviewed
• [Journal Article] Neuronal PAS domain protein 4 (Npas4) regulates neurite outgrowth and phosphorylation of synapsin I (2013)
  • Author(s): Yun, J., Nagai, T., Furukawa-Hibi, Y., Kuroda, K., Kaibuchi, K. and Yamada, K.
  • Journal Title: J . Biol. Chem Volume: 288 Pages: 2655-2664
  • Peer Reviewed
• [Journal Article] アルツハイマー型認知症治療薬について (2013)
  • Author(s): 日比陽子
  • Journal Title: ファルマシア Volume: 49(6) Pages: 539-543
  • NAID: 110010010583
  • Peer Reviewed
• [Journal Article] Neuronal PAS domain domain protein 4 (Npas4) regulates neurite outgrowth and phosphorylation of synapsin I. (2013)
  • Author(s): Yun J, Nagai T, Furukawa-Hibi Y, Kuroda K, Kaibuchi K, Greenberg ME, and Yamada K
  • Journal Title: J. Biol. Chem. Volume: 288 Issue: 4 Pages: 2655-2664
  • DOI: 10.1074/jbc.m112.413310
  • Peer Reviewed
• [Journal Article] Transcriptional suppression of the neuronal PAS domain 4 (Npas4) gene by stress via the binding of agonist-bound glucocorticoid receptor to its promoter (2012)
  • Author(s): Furukawa-Hibi, Y., Yun, J., Nagai, T. and Yamada, K.
  • Journal Title: J . Neurochem Volume: 123 Pages: 866-875
  • Peer Reviewed
• [Journal Article] Absence of SHATI/Nat8l reduces social interaction in mice (2012)
  • Author(s): Furukawa-Hibi, Y., Nitta, A., Furukawa, S., Nabeshima, T. and Yamada, K.(他3名)
  • Journal Title: Neurosci. Lett Volume: 526 Pages: 79-84
  • Peer Reviewed
• [Journal Article] Somatic mosaicism for oncogenic NRAS mutations in juvenile myelomonocytic leukemia (2012)
  • Author(s): Doisaki, S., Muramatsu, H., Shimada, A., Furukawa-Hibi, Y., Yamada, K., Tanaka, M., Hama, A., Koike, K. and Kojima, S.(他16名)
  • Journal Title: Blood Volume: 120(7) Pages: 1485-1488
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• [Journal Article] Using peripheral blood circulating DNAs to detect CpG global methylation status and genetic mutations in patients with myelodysplastic syndrome (2012)
  • Author(s): Iriyama, C., Tomita, A., Furukawa-Hibi, Y., Yamada, K., Kiyoi, H., Naoe, T.(他2名)
  • Journal Title: Biochem Biophys Res Commun Volume: 419(4) Pages: 662-669
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• [Journal Article] 神経系におけるブチリルコリンエステラーゼの機能 (2012)
  • Author(s): 日比陽子, 山田清文
  • Journal Title: Clinical Neuroscience Volume: 30(6) Pages: 672-674
  • Peer Reviewed
• [Journal Article] ストレスにより誘発される脳機能障害とストレス応答性転写因子Npas4の機能解析 (2012)
  • Author(s): 永井拓, 尹在錫, 衣斐大祐, 小池宏幸, 日比陽子, 山田清文
  • Journal Title: 日本薬理学雑誌 Volume: 139 Pages: 147-151
  • NAID: 10030572362
• [Journal Article] Transcriptional suppression of the neuronal PAS domain 4 (Npas4) gene by stress via the binding of agonist-bound glucocorticoid receptor to its promoter (2012)
  • Author(s): Furukawa-Hibi Y, Yun J, Nagai T, and Yamada K
  • Journal Title: J Neurochem Volume: 123 Issue: 5 Pages: 866-875
  • DOI: 10.1111/jnc.12034
  • Peer Reviewed
• [Journal Article] Absence of SHATI/Nat8l reduces social interaction in mice. (2012)
  • Author(s): Furukawa-Hibi Y, Nitta A, Fukumitsu H, Somiya H, Toriumi K, Furukawa S, Nabeshima T, Yamada K.
  • Journal Title: Neurosci Lett. Volume: 526 Issue: 2 Pages: 79-84
  • DOI: 10.1016/j.neulet.2012.08.028
  • Peer Reviewed
• [Journal Article] Somatic mosaicism for oncogenic NRAS mutations in juvenile myelomonocytic leukemia (2012)
  • Author(s): Doisaki S, Muramatsu H, Shimada A, Takahashi Y, Mori-Ezaki M, Sato M, Kawaguchi H, Kinoshita A, Sotomatsu M, Hayashi Y, Furukawa-Hibi Y, Yamada K, Hoshino H, Kiyoi H, Yoshida N, Sakaguchi H, Narita A, Wang X, Ismael O, Xu Y, Nishio N, Tanaka M, Hama A, Koike K, Kojima S
  • Journal Title: Blood Volume: 120 Issue: 7 Pages: 1485-1488
  • DOI: 10.1182/blood-2012-02-406090
  • Peer Reviewed
• [Journal Article] Using peripheral blood circulating DNAs to detect CpG global methylation status and genetic mutations in patients with myelodysplastic syndrome (2012)
  • Author(s): Chisako Iriyama
  • Journal Title: Biochem Biophys Res Commun Volume: (in press) Issue: 4 Pages: 662-669
  • DOI: 10.1016/j.bbrc.2012.02.071
  • Peer Reviewed
• [Journal Article] 神経系におけるブチリルコリンエステラーゼの機能 (2012)
  • Author(s): 日比陽子、山田清文
  • Journal Title: Clinical Neuroscience Volume: 30 Pages: 672-674
• [Journal Article] Periocular injection of in situ hydrogels containing Leu-Ile, an inducer for neurotrophic factors, promotes retinal ganglion cell survival after optic nerve injury (2011)
  • Author(s): Nakatani, M., Shinohara, Y., Furukawa-Hibi, Y., Miyamoto, Y., Nitta, A.(他4名)
  • Journal Title: Experimental Eye Research Volume: 96(6) Pages: 873-879
  • Peer Reviewed
• [Journal Article] Butyrylcholinesterase inhibitors ameliorate cognitive dysfunction induced by amyloid-βpeptide in mice (2011)
  • Author(s): Furukawa-Hibi, Y., Alkam T., Nitta, A., Nagai, T. and Yamada, K.(他6名)
  • Journal Title: Behavioural Brain Research Volume: 225 Pages: 222-229
  • Peer Reviewed
• [Journal Article] The hydrophobic dipeptide Leu-Ile inhibits immobility induced by repeated forced swimming via the induction of BDNF (2011)
  • Author(s): Furukawa-Hibi, Y., Nitta, A., Ikeda, T., Nabeshima, T., and Yamada, K.(他4名)
  • Journal Title: Behavioural Brain Research Volume: 220 Pages: 271-280
  • Peer Reviewed
• [Journal Article] ストレスによる精神疾患の発症にDNAメチル化が関与する (2011)
  • Author(s): 日比陽子
  • Journal Title: ファルマシア Volume: 47(7) Pages: 663-664
  • NAID: 110009900999
  • Peer Reviewed
• [Journal Article] The hydrophobic dipeptide Leu-Ile inhibits immobility induced by repeated forced swimming via the induction of BDNF. (2011)
  • Author(s): Furukawa-Hibi, Y., Nitta, A., Ikeda, T., Morishita, K., Liu W, Ibi D., Alkam, T., Nabeshima, T., and Yamada, K.
  • Journal Title: Behavioural Brain Research Volume: 220 Pages: 271-280
  • Peer Reviewed
• [Journal Article] Butyrylcholinesterase inhibitors ameliorate cognitive dysfunction induced by amyloid-β peptide in mice. (2011)
  • Author(s): Furukawa-Hibi, Y., Alkam T., Nitta, A., Matsuyama, A., Mizoguchi, H., Suzuki, K., Moussaoui, S., Yu, Q-S., Greig, N., Nagai, T. and Yamada, K.
  • Journal Title: Behavioural Brain Research Volume: 225 Pages: 222-229
  • Peer Reviewed
• [Presentation] 脳特異的転写因子Npas4欠損マウスにおける異常行動とGABA作動性神経系マーカーの変化 (2013)
  • Author(s): 日比(古川)陽子, 横井順平, 永井拓, 山田清文
  • Organizer: 第123回日本薬理学会近畿部会
  • Place of Presentation: 愛知県名古屋市愛知県産業労働センター
  • Year and Date: 2013-07-12
• [Presentation] 長期ストレスはGABA神経関連転写因子Npas4遺伝子のDNAメチル化を亢進するChronic stress increases DNA methylation of Neuronal PAS domain 4 (Npas4) (2013)
  • Author(s): 日比(古川)陽子, 永井拓, 山田清文
  • Organizer: 第23回日本臨床精神神経薬理学会・第43回日本神経精神薬理学会合同年会
  • Place of Presentation: 沖縄県宜野湾市沖縄コンベンションセンター
• [Presentation] Transcriptional suppression of the neuronal PAS domain 4 (Npas4) gene by stress via glucocorticoid receptor in the brain (2013)
  • Author(s): Yoko Hibi, Jaesuk Yun, Taku Nagai, Kiyofumi Yamada
  • Organizer: 11th WFSBP
  • Place of Presentation: 京都府京都市京都国際会館
• [Presentation] グルココルチコイド受容体は神経分化関連因子NPAS4の転写を直接抑制するDirect transcriptional regulation of neuronal transcription factor Npas4 by glucocorticoid receptor (2013)
  • Author(s): Yoko Hibi, Jaesuk Yun, Taku Nagai, Kiyofumi Yamada
  • Organizer: 第86回日本薬理学会
  • Place of Presentation: 福岡県博多市福岡国際会議場
• [Presentation] Transcriptional suppression of the neuronal PAS domain 4 (Npas4) gene by stress via glucocorticoid receptor in the brain (2013)
  • Author(s): Yoko Hibi, Jaesuk Yun, Taku Nagai, and Kiyofumi Yamada
  • Organizer: 11th WFSBP
  • Place of Presentation: 京都市 京都国際会議場
• [Presentation] 長期ストレスはGABA神経関連転写因子Npas4遺伝子のDNAメチル化を亢進する Chronic stress increases DNA methylation of Neuronal PAS domain 4 (Npas4) (2013)
  • Author(s): 日比（古川） 陽子、永井 拓、山田 清文
  • Organizer: 第23回日本臨床精神神経薬理学会・第43回日本神経精神薬理学会合同年会
  • Place of Presentation: 宜野湾市 沖縄コンベンションセンター
• [Presentation] グルココルチコイド受容体は神経分化関連因子NPAS4の転写を直接抑制する Direct transcriptional regulation of neuronal transcription factor Npas4 by glucocorticoid receptor (2013)
  • Author(s): Yoko Hibi, Jaesuk Yun, Taku Nagai, and Kiyofumi Yamada
  • Organizer: 第86回日本薬理学会年会
  • Place of Presentation: 福岡国際会議場（福岡）
• [Presentation] Glucocorticoid reduces the gene expression of neuronal PAS domain 4 (Npas4) in the brain (2012)
  • Author(s): Yoko Hibi, Jaesuk Yun, Taku Nagai, Kiyofumi Yamada
  • Organizer: ASCB2012
  • Place of Presentation: USAサンフランシスコ
• [Presentation] Stress regulates the gene expression of neuronal transcription factor Npas4 via glucocorticoid (2012)
  • Author(s): Yoko Hibi, Jaesuk Yun, Taku Nagai, Kiyofumi Yamada
  • Organizer: 第4回GCOE国際シンポジウム
  • Place of Presentation: 愛知県名古屋市ウエスティンナゴヤキャッスルホテル
• [Presentation] Transcriptional regulation of neuronal PAS domain 4 (NPAS4) by glucocorticoid receptor (2012)
  • Author(s): Yoko Hibi, Jaesuk Yun, Taku Nagai, Kiyofumi Yamada
  • Organizer: The 11th APSN,The 55th J SN(日本神経化学会)
  • Place of Presentation: 兵庫県神戸市神戸国際会議場
• [Presentation] Stress regulates the gene expression of neuronal PAS domain 4 (Npas4), via glucocorticoid receptor (2012)
  • Author(s): Yoko Hibi, Jaesuk Yun, Taku Nagai, Kiyofumi Yamada
  • Organizer: CINP 2012
  • Place of Presentation: スウェーデンストックホルム
• [Presentation] グルココルチコイドによる転写因子NPAS4の発現抑制機構Glucocorticoid regulates the expression of neuronal PAS domain 4 (Npas4) (2012)
  • Author(s): 日比陽子, ユンジェスク, 永井拓, 山田清文
  • Organizer: 第7回統合失調症学会
  • Place of Presentation: 愛知県名古屋市愛知県産業労働センター
• [Presentation] ブチリルコリンエステラーゼ阻害剤のアミロイドベータ誘発性認知機能障害改善効果Butyrylcholinesterase inhibitors ameliorate cognitive dysfunction induced by amyloid-β peptide in mice (2012)
  • Author(s): 日比(古川)陽子, アルカム・トルソン, 新田淳美, 松山明裕, 永井拓, 山田清文
  • Organizer: 第85回日本薬理学会年会
  • Place of Presentation: 京都府京都市京都国際会館
• [Presentation] Stress regulates the gene expression of neuronal PAS domain 4 (Npas4), via glucocorticoid receptor (2012)
  • Author(s): Yoko Hibi, Jaesuk Yun, Taku Nagai, and Kiyofumi Yamada
  • Organizer: CINP 2012
  • Place of Presentation: ストックホルム スウェーデン
• [Presentation] Transcriptional regulation of neuronal PAS domain 4 (NPAS4) by glucocorticoid receptor (2012)
  • Author(s): Yoko Hibi, Jaesuk Yun, Taku Nagai, and Kiyofumi Yamada
  • Organizer: The 11th APSN The 55th JSN（日本神経化学会）
  • Place of Presentation: 神戸国際会議場（兵庫）
• [Presentation] Stress regulates the gene expression of neuronal transcription factor Npas4 via glucocorticoid (2012)
  • Author(s): Yoko Hibi, Jaesuk Yun, Taku Nagai, and Kiyofumi Yamada
  • Organizer: 第４回GCOE国際シンポジウム
  • Place of Presentation: 名古屋キャッスルホテル（愛知）
• [Presentation] Glucocorticoid reduces the gene expression of neuronal PAS domain 4 (Npas4) in the brain (2012)
  • Author(s): Yoko Hibi, Jaesuk Yun, Taku Nagai, and Kiyofumi Yamada
  • Organizer: ASCB2012
  • Place of Presentation: サンフランシスコ USA
• [Presentation] 神経発達関連転写因子NPAS4のストレスによる転写抑制機構の解明 (2011)
  • Author(s): 日比(古川)陽子, ユンジェスク, 永井拓, 山田清文
  • Organizer: 第119回日本薬理学会近畿部会
  • Place of Presentation: 愛知県名古屋市愛知県産業労働センター
  • Year and Date: 2011-07-08
• [Presentation] 神経発達関連転写因子NPAS4の発現調節機構の解明 (2011)
  • Author(s): 日比(古川)陽子, ユンジェスク, 永井拓, 山田清文
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 神奈川県横浜市パシフィコ横浜
• [Presentation] Stress reduces the expression of transcription factor, neuronal PAS domain 4 (NPAS4) (2011)
  • Author(s): Yoko Hibi, Jaesuk Yun, Taku Nagai, Kiyofumi Yamada
  • Organizer: AsCNP2011
  • Place of Presentation: 韓国ソウル市
• [Presentation] ストレスによるneuronal PAS domain 4 (NPAS4)の転写制御Transcriptional regulation of neuronal PAS domain 4 (NPAS4) by stress (2011)
  • Author(s): Yoko Hibi, Jaesuk Yun, Taku Nagai, Kiyofumi Yamada
  • Organizer: Neuroscience 2011
  • Place of Presentation: 神奈川県横浜市パシフィコ横浜
• [Presentation] 脳特異的転写因子Npas4欠損マウスにおける異常行動とGABA作動性神経系マーカーの変化
  • Author(s): 日比（古川） 陽子、横井 順平、永井 拓、山田 清文
  • Organizer: 第123回日本薬理学会近畿部会
  • Place of Presentation: 名古屋市 ウインク愛知
• [Presentation] 神経発達関連転写因子NPAS4のストレスによる転写抑制機構の解明
  • Author(s): 日比（古川）陽子、ユン ジェスク、永井 拓、 山田 清文
  • Organizer: 第119回日本薬理学会近畿部会
  • Place of Presentation: 名古屋 愛知県産業労働センター
• [Presentation] Transcriptional regulation of neuronal PAS domain 4 (NPAS4) by stress ストレスによるneuronal PAS domain 4 (NPAS4)の転写制御
  • Author(s): Yoko Hibi, Jaesuk Yun, Taku Nagai, Kiyofumi Yamada
  • Organizer: Neuroscience 2011
  • Place of Presentation: 横浜 パシフィコ横浜
• [Presentation] Stress reduces the expression of transcription factor, neuronal PAS domain 4 (NPAS4)
  • Author(s): Yoko Hibi, Jaesuk Yun, Taku Nagai and Kiyofumi Yamada
  • Organizer: AsCNP
  • Place of Presentation: 韓国 ソウル
• [Presentation] 神経発達関連転写因子NPAS4の発現調節機構の解明
  • Author(s): 日比（古川）陽子、ユン ジェスク、永井 拓、 山田 清文
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 国立京都国際会館・グランドプリンスホテル京都
• [Presentation] グルココルチコイドによる転写因子NPAS4の発現抑制機構 Glucocorticoid regulates the expression of neuronal PAS domain 4 (Npas4).
  • Author(s): 日比 陽子、ユン ジェスク、永井 拓、山田 清文
  • Organizer: 第7回統合失調症学会
  • Place of Presentation: 名古屋 愛知県産業労働センター
• [Presentation] Npas4 regulates neurite outgrowth and phosphoryation of synapsin I
  • Author(s): Jaesuk Yun, Taku Nagai, Yoko Hibi, Keisuke Kuroda, Kozo Kaibuchi, Kiyofumi Yamada
  • Organizer: Neuroscience 2011
  • Place of Presentation: 横浜 パシフィコ横浜
• [Presentation] The Role of Npas4 in Neurite Outgrowth and phosphorylation of Synapsin I
  • Author(s): Jaesuk Yun, Taku Nagai, Yoko Hibi, Keisuke Kuroda, Kozo Kaibuchi, Kiyofumi Yamada
  • Organizer: AsCNP
  • Place of Presentation: 韓国 ソウル
• [Presentation] Methamphetamine-induced Npas4; possible role in neurite outgrowth and p-synapsin I expression
  • Author(s): Yun Jaesuk, Nagai Taku, Hibi Yoko, Kuroda Keisuke, Kaibuchi Kozo,Yamada Kiyofumi
  • Organizer: 平成23年度アルコール・薬物依存関連学会合同学術総会
  • Place of Presentation: 名古屋 愛知県産業労働センター