| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
|---|
| Outline of Final Research Achievements |
Hippocampus, a part of the limbic system, shrinks in depressive patients. It is also reported that dendritic arbors shrink, and that the density of spines that form excitatory synapses decreases in hippocampus. All these parameters recover in individuals successfully treated with antidepressants. Arcadlin (or Protocadherin-8; Paraxial protocadherin) is a protocadherin-type cell adhesion molecule induced in hippocampal neurons by these treatments. Arcadlin is known to regulate spine density. The effect of antidepressants was rather enhanced in arcadlin-gene deleted mouse. The data suggest that Arcadlin is induced by antidepressants, but shows an antagonistic effect against the drug’s action.
|
