Activation of hippocampal protocadherin-MAP kinase cascade by the treatment of depression
| Project/Area Number |
23590300
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Ritsumeikan University (2013-2015)
Osaka University (2011-2012) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAGATA Kanato 公益財団法人・東京都医学総合研究所, シナプス可塑性プロジェクト, プロジェクトリーダー (20263262)
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| Project Period (FY) |
2011-04-28 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 抗うつ薬 / シナプス可塑性 / 海馬 / プロトカドヘリン / マップキナーゼ / 接着分子 / 樹状突起スパイン / 行動解析 / スパイン / うつ病 / 遺伝子発現 / 電気けいれん療法 / 細胞接着分子 |
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| Outline of Final Research Achievements |
Hippocampus, a part of the limbic system, shrinks in depressive patients. It is also reported that dendritic arbors shrink, and that the density of spines that form excitatory synapses decreases in hippocampus. All these parameters recover in individuals successfully treated with antidepressants. Arcadlin (or Protocadherin-8; Paraxial protocadherin) is a protocadherin-type cell adhesion molecule induced in hippocampal neurons by these treatments. Arcadlin is known to regulate spine density. The effect of antidepressants was rather enhanced in arcadlin-gene deleted mouse. The data suggest that Arcadlin is induced by antidepressants, but shows an antagonistic effect against the drug’s action.
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Report
(6 results)
Research Products
(41 results)
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[Journal Article] Activation of Rheb, but not of mTORC1, impairs spine synapse morphogenesis in tuberous sclerosis complex.2014
Author(s)
Yasuda S, Sugiura H, Katsurabayashi S, Shimada T, Tanaka H, Takasaki K, Iwasaki K, Kobayashi T, Hino O, Yamagata K.
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Journal Title
Sci Rep.
Volume: 4
Issue: 1
Pages: 5155-5155
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Transport of 3-fluoro-L-α-methyl-tyrosine by tumor-upregulated L-type amino acid transporter 1: a cause of the tumor uptake in PET.2012
Author(s)
Wiriyasermkul P, Nagamori S, Tominaga H, Oriuchi N, Kaira K, Nakao H, Kitashoji T, Ohgaki R, Tanaka H, Endou H, Endo K, Sakurai H, Kanai Y.
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Journal Title
J Nucl Med.
Volume: 53
Issue: 8
Pages: 1253-1261
DOI
Related Report
Peer Reviewed
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[Journal Article] Transport of 3-fluoro-L-alpha-methyl tyrosine by tumor-upregulated amino acid transporter LAT-1: a cause of the tumor uptake in PET.2012
Author(s)
Wiriyasermkul P, Nagamori S, Tominaga H, Oriuchi N, Kaira K, Nakao H, Kitashoji T, Ohgaki R, Tanaka H, Endou H, Endo K, Sakurai H, Kanai Y.
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Journal Title
J Nucl Med.
Volume: in press
Related Report
Peer Reviewed
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[Journal Article] Methamphetamine induces endoplasmic reticulum stress related gene CHOP/Gadd153/ddit3 in dopaminergic cells.2011
Author(s)
Irie Y, Saeki M, Tanaka H, Kanemura Y, Otake S, Ozono Y, Nagai T, Kondo Y, Kudo K, Kamisaki Y, Miki N, Taira E.
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Journal Title
Cell Tissue Res.
Volume: 345
Pages: 231-241
Related Report
Peer Reviewed
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[Journal Article] Retrospective review of Japanese sudden unexpected death in infancy: the importance of metabolic autopsy and expanded newborn screening.2011
Author(s)
Yamamoto T, Tanaka H, Kobayashi H, Okamura K, Tanaka T, Emoto Y, Sugimoto K, Nakatome M, Sakai N, Kuroki H, Yamaguchi S, Matoba R.
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Journal Title
Mol Genet Metab.
Volume: 102
Pages: 399-406
Related Report
Peer Reviewed
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[Presentation] シナプスの構築と薬理学2016
Author(s)
田中秀和
Organizer
大阪大学医学部薬理学講演会
Place of Presentation
大阪大学中之島センター（大阪府大阪市）
Year and Date
2016-01-09
Related Report
Invited
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