| Project/Area Number |
23590302
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Shimane University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TANAKA Tetsuya 島根大学, 医学部, 助教 (10346380)
SHIMBORI Chiko 島根大学, 医学部, 助教 (40437554)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 関節リウマチ / 肥満細胞 / 慢性炎症 / 骨粗鬆症 |
|---|
| Research Abstract |
The number of mast cells was markedly increased in the inflamed paws of collagen-induced arthritis in mice, and mast cells were one of the major cells producing TNF-alpha. TNF-alpha positive mast cells were present extensively throughout the inflamed synovium of arthritic mice, and some of the mast cells were in close proximity of osteoclasts in the area of marked bone and cartilage destruction. Treatment with a mast cell membrane stabilizer for 8 weeks and chymase inhibitor for 4 weeks significantly reduced clinical and X-ray scores of collagen-induced arthritis, and decreased the number of TNF-alpha positive mast cells and the mRNA levels of TNF-alpha in the inflamed paws of arthritic mice. The number of osteoclasts was also decreased by treatment with a mast cell membrane stabilizer and chymase inhibitor. These observations suggest that mast cells may be involved in bone metabolism and pathogenesis of collagen-induced arthritis in mice.
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