| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
There is increasing evidence implicating aldosterone, in addition to angiotensin II, in the pathogenesis of hypertension and renal diseases. We have demonstrated that aldosterone causes renal injury through the activation of MR in aldosterone-infused rats, Dahl salt-sensitive hypertensive rats, but in angiotensin II-infused hypertensive mice. In the kidney, MR is expressed not only in destal tubules, but also in glomerular mesangial cells, podocytes, proximal tubular cells, and fibroblasts. In these cells, MR activation causes cell injury via oxidative stress and senescence. These data suggest that MR blockers provide a potential therapeutic approach for patients with hypertension and renal impairment.
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