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Degradation of cation channel and the dysfunction

Research Project

Project/Area Number 23590312
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General pharmacology
Research InstitutionAichi Gakuin University

Principal Investigator

MURAKI Katsuhiko  愛知学院大学, 薬学部, 教授 (20254310)

Co-Investigator(Kenkyū-buntansha) HATANO Noriyuki  愛知学院大学, 薬学部, 講師 (50454319)
SUZUKI Hiroka  愛知学院大学, 薬学部, 助教 (00581026)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsチャネル / タンパク発現制御 / 炎症 / TRPチャネル / 転写 / タンパク分解 / カチオンチャネル / 細胞異常 / イオンチャネル / ユビキチン
Research Abstract

In this research project, we have found that TRPA1 channel, a subfamily of TRP cation channel, is substantially induced by inflammatory stimuli in channel-expression and channel-function levels; a transcriptiona factor, which is activated in hypoxia, is involved in the induction and TRPA1 gene promoter has a specific binding site of the factor. Because TRPA1 channel is involved in nociception, the present finding may contribute to developement of novel drugs for inflammatory nociception.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (28 results)

All 2014 2013 2012 2011 Other

All Journal Article (12 results) (of which Peer Reviewed: 5 results) Presentation (13 results) (of which Invited: 2 results) Remarks (3 results)

  • [Journal Article] TRPV4 partially participates in proliferation of human brain capillary endothelial cells2013

    • Author(s)
      N. Hatano, H Suzuki, Y. Itoh & K. Muraki
    • Journal Title

      Life Sci.

      Volume: 92 Pages: 317-324

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] Stimulation of human TRPA1 channels by clinical concentrations of the anti-rheumatic drug, auranofin2013

    • Author(s)
      N Hatano, H Suzuki, Y Muraki & K Muraki
    • Journal Title

      Am. J. Physiol.,.Cell-Physiol.

      Volume: 304

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] HIF1αswitches on TRPA1 gene expression via a hypoxia response element-like motif to modulate cytokine release2012

    • Author(s)
      N Hatano, Y Itoh, H Suzuki, Y Muraki, H Hayashi, K Onozaki, IC Wood, DJ Beech & K Muraki
    • Journal Title

      J. Biol. Chem.

      Volume: 287 Pages: 31962-31972

    • Related Report
      2013 Final Research Report
  • [Journal Article] Involvement of inositol 1,4,5-trisphosphate formation in the voltage-dependent regulation of the Ca^<2+> concentration in porcine coronary arterial smooth muscle cells2012

    • Author(s)
      Yamamura H, S Ohya, K Muraki & Y Imaizumi
    • Journal Title

      J. Pharmacol. Exp. Therap.

      Volume: 342 Pages: 486-486

    • Related Report
      2013 Final Research Report
  • [Journal Article] Pregnenolone sulphate-independent inhibition of TRPM3 channels by progesterone2012

    • Author(s)
      Jiang, H Picton, K Porter, D O'Regan, K Muraki, C Fishwick & D Beech
    • Journal Title

      Cell Calcium

      Volume: 55 Pages: 1-11

    • Related Report
      2013 Final Research Report
  • [Journal Article] Pregnenolone sulphate-independent inhibition of TRPM3 channels by progesterone.2012

    • Author(s)
      Majeed, Y., S Tumova, B Green, V Seymour, D Woods, A Agarwal, J Naylor, S Jiang, H Picton, K Porter, D O’Regan, K Muraki, C Fishwick & D Beech
    • Journal Title

      Cell Calcium

      Volume: 55 Issue: 1 Pages: 1-11

    • DOI

      10.1016/j.ceca.2011.09.005

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Involvement of IP(3) formation in the voltage-dependent regulation of the Ca(2+) concerntration in porcine coronary arterial smooth muscle cells.2012

    • Author(s)
      Hisao Yamamura
    • Journal Title

      J. Pharmacol. Exp. Ther

      Volume: 342(2) Issue: 2 Pages: 486-496

    • DOI

      10.1124/jpet.112.194233

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] HIF1α switches on TRPA1 gene expression via a hypoxia response element-like motif to modulate cytokine release2012

    • Author(s)
      N Hatano, Y Itoh, H Suzuki, Y Muraki, H Hayashi, K Onozaki, IC Wood, DJ Beech & K Muraki
    • Journal Title

      J. Biol. Chem.

      Volume: 287 Issue: 38 Pages: 31962-31972

    • DOI

      10.1074/jbc.m112.361139

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] TRPC5 channel sensitivities to antioxidants and hydroxylated stilbens2011

    • Author(s)
      J Naylor, E Shawaf, P Manna, L McKeown, P Manna, K. Porter, D O'Regan, K Muraki, D Beech
    • Journal Title

      J. Biol. Chem.

      Volume: 286 Pages: 5078-5086

    • Related Report
      2013 Final Research Report
  • [Journal Article] Stereo-selective inhibition of TRPC5 channels by neuroactive steroids2011

    • Author(s)
      Y Majeed, M Amer, A Agarwal, L McKeown, K Porter, D O'Regan, J Naylor, C Fishwick, K Muraki, D Beech
    • Journal Title

      B. J. Pharmacol.

      Volume: 162 Pages: 1509-1520

    • Related Report
      2013 Final Research Report
  • [Journal Article] TRPC5 channel sensitivities to antioxidants and hydroxylated stilbenes.2011

    • Author(s)
      J. Naylor
    • Journal Title

      Journal of Biological Chemistry

      Volume: 286 Issue: 7 Pages: 5078-5086

    • DOI

      10.1074/jbc.m110.196956

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Stereo-selective inhibition of TRPC5 channels by neuroactive steroids.2011

    • Author(s)
      Majeed, Y
    • Journal Title

      British Journal of Pharmacology

      Volume: 162 Issue: 7 Pages: 1509-1520

    • DOI

      10.1111/j.1476-5381.2010.01136.x

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Transcriptional regulation of TRPA1 channel : Links between inflammation and channel expression Finish Pharmacological Society2014

    • Author(s)
      Katsuhiko Muraki
    • Organizer
      Annual meeting 2014
    • Place of Presentation
      Tampere, Finland
    • Year and Date
      2014-04-07
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Transcriptiona regulation of TRPA1 channel: Links between inflammation and channel expression2014

    • Author(s)
      Katsuhiko Muraki
    • Organizer
      Finish Pharmacological Society, Annual Meeting 2014
    • Place of Presentation
      Tampere, Finland
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ヒト脳毛細血管内皮細胞においてhistamineにより惹起されるCl-電流におけるanoctaminチャネルの寄与の検討2013

    • Author(s)
      波多野紀行, 鈴木裕可, 村木由起子, 大矢進, 村木克彦
    • Organizer
      第123回日本薬理学会近畿部会
    • Place of Presentation
      名古屋(B-5)
    • Year and Date
      2013-07-12
    • Related Report
      2013 Final Research Report
  • [Presentation] 低酸素誘導因子HIF1αによるTRPA1チャネル発現制御機構2013

    • Author(s)
      波多野紀行, 伊藤友香, 鈴木裕可, 村木由起子, 林秀敏, 小野嵜菊夫, Wood Ian,Beech David, 村木克彦
    • Organizer
      平成25年度日本薬学会東海支部総会・大会
    • Place of Presentation
      名古屋(H1510)
    • Year and Date
      2013-07-06
    • Related Report
      2013 Final Research Report
  • [Presentation] NADPHオキシダーゼ阻害剤はTRPA1チャネルを活性化する2013

    • Author(s)
      鈴木裕可, 波多野紀行, 村木由起子, 伊藤友香, 林秀敏, 小野嵜菊夫, 村木克彦
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜(29amp-123)
    • Year and Date
      2013-03-29
    • Related Report
      2013 Final Research Report
  • [Presentation] 炎症性刺激により誘導されるTRPA1は細胞内亜鉛濃度を制御する2013

    • Author(s)
      波多野紀行, 鈴木裕可, 村木由起子, 伊藤友香, 林秀敏, 小野嵜菊夫, Wood Ian,Beech David, 村木克彦
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜(29amp-117)
    • Year and Date
      2013-03-29
    • Related Report
      2013 Final Research Report
  • [Presentation] 滑膜線維芽様細胞におけるTRPA1発現誘導を介したサイトカイン分泌制御機構2013

    • Author(s)
      波多野紀行, 伊藤友香, 鈴木裕可, 村木由起子, 林秀敏, 小野嵜菊夫, Wood Ian,Beech David, 村木克彦
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜(29amp-118)
    • Year and Date
      2013-03-29
    • Related Report
      2013 Final Research Report
  • [Presentation] Transcriptional regulation of transient receptor potential ankyrin 1 channel gene expression by hypoxia inducible factor-1α2013

    • Author(s)
      Noriyuki Hatano, Yuka Itoh, Hiroka Suzuki, Yukiko Muraki, Hidetoshi Hayashi, Kikuo Onozaki, Ian Wood, David Beech, Katsuhiko Muraki
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡(P3-89)
    • Year and Date
      2013-03-23
    • Related Report
      2013 Final Research Report
  • [Presentation] TRPA1 channel is a key regulator of intracellular Zn^<2+> in inflammatory synoviocytes2013

    • Author(s)
      Noriyuki Hatano, Hiroka Suzuki, Yuka Itoh, Yukiko Muraki, Hidetoshi Hayashi, Kikuo Onozaki, Katsuhiko Muraki
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡(P2-98)
    • Year and Date
      2013-03-22
    • Related Report
      2013 Final Research Report
  • [Presentation] Potent activation of TRPA1 channel by NADPH oxidase inhibitors2013

    • Author(s)
      Hiroka Suzuki, Noriyuki Hatano, Yukiko Muraki, Yuka Itoh, Hidetoshi Hayashi, Kikuo Onozaki, Katsuhiko Muraki
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡(P1-151)
    • Year and Date
      2013-03-21
    • Related Report
      2013 Final Research Report
  • [Presentation] Inflammatory stimulation induces expression of TRPA1 channel to regulate cytokine release2013

    • Author(s)
      Noriyuki Hatano, Yuka Itoh, Hiroka Suzuki, Yukiko Muraki, Hidetoshi Hayashi, Kikuo Onozaki, Ian Wood, David Beech, Katsuhiko Muraki
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡(P1-99)
    • Year and Date
      2013-03-21
    • Related Report
      2013 Final Research Report
  • [Presentation] Selective and potent activation of human TRPA1 by a disease modifying anti-rheumatic drug, auranofin2012

    • Author(s)
      Noriyuki Hatano, Erika Kusugami, Erina Kamiya, Hiroka Suzuki, Yukiko Muraki, Katsuhiko Muraki
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都(P2-19-3)
    • Year and Date
      2012-03-15
    • Related Report
      2013 Final Research Report
  • [Presentation] 非神経細胞におけるTRPV4の機能と活性調節

    • Author(s)
      波多野紀行
    • Organizer
      日本薬学会第131年会(招待講演)
    • Place of Presentation
      静岡県
    • Related Report
      2011 Research-status Report
  • [Remarks] ホームページ

    • URL

      http://www.phar.agu.ac.jp/lab/cell_pharm/cellpharmacol.html

    • Related Report
      2013 Final Research Report
  • [Remarks] 薬効解析学講座

    • URL

      http://www.phar.agu.ac.jp/lab/cell_pharm/cellpharmacol.html

    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://www.phar.agu.ac.jp/lab/cell_pharm/cellpharmacol.html

    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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