Significance of chymase inhibition to prevent the complication of metabolic syndrome
Project/Area Number |
23590313
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General pharmacology
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Research Institution | Osaka Medical College |
Principal Investigator |
TAKAI Shinji 大阪医科大学, 医学部, 准教授 (80288703)
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Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | キマーゼ / メタボリックシンドローム / 合併症 / 阻害薬 / 高血圧 / NASH / 脳卒中 / 血管障害 / NASH / 肝臓線維化 / 炎症 / 血管機能障害 / 心機能障害 / 腎機能障害 / アンジオテンシンII / 心臓障害 / 腎臓障害 / 動脈硬化 |
Research Abstract |
Effects of the chymase inhibitor were evaluated on animal models with the non-alcoholic steatohepatitis (NASH) and stroke-prone spontaneously hypertensive (SHR-SP) rats as complications of the metabolic syndrome. In a hamster NASH model, plasma levels of AST and ALT were improved by the chymase inhibitor and the improvement of lipid deposition and fibrosis was also observed. In SHR-SP rats, the chymase inhibitor showed to prevent the vascular endothelial dysfunction via the anti-oxidative effect and the prevention of inflammatory cell-infiltration into the endothelium without hypotensive effect. The chymase inhibitor also extended the survival term. These results suggest that chymase inhibition become the useful strategy to prevent the complication of metabolic syndrome.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Chymase Inhibition Attenuates Monocrotaline-Induced Sinusoidal Obstruction Syndrome in Hamsters.2013
Author(s)
Masubuchi S, Komeda K, Takai S, Jin D, Tashiro K, Li ZL, Otsuki Y, Otsuki Y, Okamura H, Hayashi M, Uchiyama K.
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Journal Title
Curr Med Chem
Volume: 印刷中
Related Report
Peer Reviewed
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