Elucidation of abnormalities of neurogenesis and brain niche in stress-related disorders
| Project/Area Number |
23590321
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | National Defense Medical College |
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Principal Investigator |
WATANABE Yasuhiro 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 医学教育部医学科専門課程, 教授 (90127324)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIZUKA Toshiaki 防衛医科大学校, 医学教育部医学科専門課程, 准教授 (30399117)
MATSUURA Nariaki 大阪大学, 大学院医学研究科, 教授 (70190402)
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| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 神経新生 / GPR56 / 神経前駆細胞 / 細胞外マトリックス / アドレナリン受容体 |
|---|
| Research Abstract |
Transfection of GPR56 siRNA significantly inhibited neural diffrentiation of mouse induced pluripotent stem cells (iPS cells). However, the transfection of GPR56 siRNA did not affect fibronectin-binding activity in mouse neural progenitor cells. Stimulation with either beta-adrenoceptor or serotonin receptor significantly enhanced neural differentiation of mouse iPS cells, but the stimulation did not affect fibronectin-binding activity in mouse neural progenitor cells. These findings suggest the involvement of GPR56, beta-adrenoceptor, and serotonin receptor on neural differentiation.
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Report
(4 results)
Research Products
(72 results)
