| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
Transfection of GPR56 siRNA significantly inhibited neural diffrentiation of mouse induced pluripotent stem cells (iPS cells). However, the transfection of GPR56 siRNA did not affect fibronectin-binding activity in mouse neural progenitor cells. Stimulation with either beta-adrenoceptor or serotonin receptor significantly enhanced neural differentiation of mouse iPS cells, but the stimulation did not affect fibronectin-binding activity in mouse neural progenitor cells. These findings suggest the involvement of GPR56, beta-adrenoceptor, and serotonin receptor on neural differentiation.
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