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Elucidation of the molecular mechanisms of early breast cancer invasion and metastasis

Research Project

Project/Area Number 23590323
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General medical chemistry
Research InstitutionHokkaido University

Principal Investigator

HASHIMOTO Ari  北海道大学, 医学(系)研究科(研究院), 助教 (60390803)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords浸潤 / 転移 / Arf6 / GEP100 / EMT / p53 / 乳癌 / AMAP1 / ArfGEF
Research Abstract

Cancer progression by which epithelial tumor cells acquire a more motile and invasive phenotype has been closely linked to the epithelial-mesenchymal transition (EMT) process. We found that GEP100-Arf6-AMAP1 pathway is important for acquisition of mesenchymal invasive phenotypes of breast cancers and TP53 alterations link to this process. Metabolic pathway regulated by mutant p53 is required for Arf6 activation. The clinical specimens of human breast cancer showed that the expression of GEP100-Arf6-AMAP1 signal correlated with recurrence after radiotherapy. Database analysis also showed that co-incidence of TP53 mutations and the high expression of this signal pathway statistically correlate with poor survival. These results suggest that generation of the Arf6-based mesenchymal invasive pathway by TP53 alterations regulate malignant progression and appears to be crucial for poor prognosis in breast cancer.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (51 results)

All 2014 2013 2012 2011 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results,  Open Access: 1 results) Presentation (29 results) Book (6 results) Remarks (3 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 2 results)

  • [Journal Article] High Level Expression of AMAP1 Protein Correlates with Poor Prognosis and Survival after Surgery of HNSCC Patients2014

    • Author(s)
      Sato H., Hatanaka K.C., Hatanaka Y., Hatakeyama H., Hashimoto A., Matsuno Y., Fukuda S., Sabe H.
    • Journal Title

      Cell Commun Signal

      Volume: 12 Pages: 12-17

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] High level expression of AMAP1 protein correlates with poor prognosis and survival after surgery of head and neck squamous cell carcinoma patients.2014

    • Author(s)
      Sato H, Hatanaka KC, Hatanaka Y, Hatakeyama H, Hashimoto A, Matsuno Y, Fukuda S, Sabe H.
    • Journal Title

      Cell Commun Signal.

      Volume: 12 Issue: 1 Pages: 17-17

    • DOI

      10.1186/1478-811x-12-17

    • NAID

      120005438264

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Co-overexpression of GEP100 and AMAP1 proteins correlates with rapid local recurrence after breast conservative therapy2013

    • Author(s)
      Kinoshita R., Nam J.M., Ito Y.M., Hatanaka K.C., Hashimoto A., Handa H., OtsukaY., Hashimoto S., Onodera Y., Hosoda M., Onodera S., Shimizu S., Tanaka S., Shirato H., Tanino M., Sabe H.
    • Journal Title

      PLoS One

      Volume: 8

    • NAID

      120005348196

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Co-overexpression of GEP100 and AMAP1 proteins correlates with rapid local recurrence after breast conservative therapy.2013

    • Author(s)
      Kinoshita R, Nam JM, Ito YM, Hatanaka KC, Hashimoto A, Handa H, Otsuka Y, Hashimoto S, Onodera Y, Hosoda M, Onodera S, Shimizu S, Tanaka S, Shirato H, Tanino M, Sabe H.
    • Journal Title

      PLoS One.

      Volume: 8 Issue: 10 Pages: e76791-e76791

    • DOI

      10.1371/journal.pone.0076791

    • NAID

      120005348196

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rab5c promotes AMAP1-PRKD2 complex formation to enhance1 integrin recycling in EGF-induced cancer invasion2012

    • Author(s)
      Onodera Y., Nam J.M., Hashimoto A., Norman JC, Shirato H, Hashimoto S., Sabe H.
    • Journal Title

      J Cell Biol

      Volume: 197 Pages: 983-996

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rab5c mediates AMAP1-PRKD2 complexto enhance β1 integrin recycling inEGF-induced cancer invasion2012

    • Author(s)
      Onodera Y., Nam JM., Hashimoto A., Norman JC., Shirato H., Hashimoto S. and Sabe H
    • Journal Title

      J.Cell Biol

      Volume: 197 Issue: 7 Pages: 983-996

    • DOI

      10.1083/jcb.201201065

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Engagement of overexpressed Her2 with GEP100 induces autonomous invasive activities and provides a biomarker for metastases of lung adenocarcinoma2011

    • Author(s)
      Menju T., Hashimoto S., Hashimoto A., Otsuka Y., Handa H., Ogawa E., Toda Y., Wada H., Date H., and Sabe H.
    • Journal Title

      PLoS One

      Volume: 6

    • NAID

      120003464637

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] GEP100-Arf6-AMAP1-cortactin pathway frequently used in cancer invasion is activated by VEGFR2 to promote angiogenesis2011

    • Author(s)
      Hashimoto A., Hashimoto S., Ando R., Noda K., Ogawa E., Kotani H., Hirose M., Menju T., Morishige M., Manabe T., Toda Y., Ishida S., and Sabe H.
    • Journal Title

      PLoS One

      Volume: 6

    • NAID

      120003295085

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] GEP100-Arf6-AMAP1-cortactin pathway frequently used in cancer invasion is activated by VEGFR2 to promote angiogenesis2011

    • Author(s)
      Hashimoto A., Hashimoto S., Ando R., Noda K., Ogawa E., Kotani H., Hirose M., Menju T., Morishige M., Manabe T., Toda Y., Ishida S. and Sabe H.
    • Journal Title

      PLoS One

      Volume: 6 Issue: 8 Pages: e23359-e23359

    • DOI

      10.1371/journal.pone.0023359

    • NAID

      120003295085

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Engagement of overexpressed Her2 with GEP100 induces autonomous invasive activities and provides a biomarker for metastases of lung adenocarcinoma2011

    • Author(s)
      Menju T., Hashimoto S., Hashimoto A., Otsuka Y., Handa H., Ogawa E., Toda Y., Wada H., Date H. and Sabe H.
    • Journal Title

      PLoS One

      Volume: 6 Issue: 9 Pages: e25301-e25301

    • DOI

      10.1371/journal.pone.0025301

    • NAID

      120003464637

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Mechanisms by which p53 alterations generate GEP100-Arf6-AMAP1 pathway as a mesenchymal invasion machinery to be activated by external ligands2013

    • Author(s)
      Hashimoto A., Hashimoto S., Onodera Y., Oikawa T., Oneyama C., Kinoshita R., Nam J.M., Tanino M., Sugino H., Yoshikawa A., Otsuka Y., Handa H., Yoshino M., Sato H., Fukuda S., Tanaka S., Shirato H., Ito Y., Okada M., Sabe H.
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2013-12-04
    • Related Report
      2013 Final Research Report
  • [Presentation] Mutant-p53 generates the GEP100-Arf6-AMAP1 pathway to promote breast cancer invasiveness2013

    • Author(s)
      Hashimoto S., Hashimoto A., Oneyama C., Yoshikawa A., Sugino H., Handa H., Yoshino M., Otsuka Y., Onodera Y., Okada M., Sabe H.
    • Organizer
      第86回日本生化学大会
    • Place of Presentation
      横浜
    • Year and Date
      2013-09-12
    • Related Report
      2013 Final Research Report
  • [Presentation] Mutant-p53 generates GEP100-Arf6-AMAP1-EPB41L5 pathway externally activated to promote mesenchymal invasion2013

    • Author(s)
      Hashimoto A., Hashimoto S., Oneyama C., Onodera Y., Sugino H., Yoshikawa A., Otsuka Y., Handa H., Okada M., Sabe H.
    • Organizer
      The First International Meeting, Epithelial Tubulology
    • Place of Presentation
      札幌
    • Year and Date
      2013-06-23
    • Related Report
      2013 Final Research Report
  • [Presentation] Mutant-p53 generates GEP100-Arf6-AMAP1-EPB41L5 pathway externally activated to promote mesenchymal invasion.2013

    • Author(s)
      Hashimoto A., Hashimoto S., Oneyama C., Onodera Y., Sugino H., Yoshikawa A., Otsuka Y., Handa H., Okada M., and Sabe H.
    • Organizer
      The First International Meeting, Epithelial Tubulology
    • Place of Presentation
      Conference Hall, Hokkaido University(札幌市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Mutant-p53 generates the GEP100-Arf6-AMAP1 pathway to promote breast cancer invasiveness.2013

    • Author(s)
      Hashimoto S., Hashimoto A., Oneyama C., Yoshikawa A., Sugino H., Handa H., Yoshino M., Otsuka Y., Onodera Y., Okada M., and Sabe H.
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Mechanisms by which oncogenic mutant-p53 generates mesenchymal invasive pathway pivotal to a radiation resistance.2013

    • Author(s)
      Sabe H., Hashimoto A., Hashimoto S., Onodera Y., Oikawa T., Nam J.M., Oneyama C., Sugino H., Yoshikawa A., Otsuka Y., Handa H., Yoshino M., and Okada M.
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Mechanisms by which p53 alterations generate GEP100-Arf6-AMAP1 pathway as a mesenchymal invasion machinery to be activated by external ligands.2013

    • Author(s)
      Hashimoto A., Hashimoto S., Onodera Y., Oikawa T., Oneyama C., Kinoshita R., Nam J.M., Tanino M., Sugino H., Yoshikawa A., Otsuka Y., Handa H., Masanao Y., Sato H., Fukuda S., Tanaka S., Shirato H., Ito Y., Okada M., and Sabe H.
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Mutant-p53 generates GEP100-Arf6-AMAP1 pathway to be activated by TGFβ1 and receptor tyrosine kinases to promote cancer invasion.2012

    • Author(s)
      Hashimoto A., Hashimoto S., Yoshikawa A., Sugino H., Handa H., Kinoshita R., Hatanaka K.C., Mikami S., Tanino M., Mito S., Sato H., Otsuka Y., Yoshino H., Kado Y., Nam J.M., Onodera Y., Tanaka S., Shirato H., Sabe H.
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-12
    • Related Report
      2013 Final Research Report
  • [Presentation] Mutant-p53 generates GEP100-Arf6-AMAP1 pathway to promote breast cancer cell invasiveness in response to TGFβ12012

    • Author(s)
      Hashimoto A., Hashimoto S., Yoshikawa A., Sugino H., Handa H., Mito S., Sato H., Otsuka Y., Yoshino H., Nam J.M., Onodera Y., Sabe H.
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-20
    • Related Report
      2013 Final Research Report
  • [Presentation] MUTANT-p53 GENERATES GEP100-Arf6-AMAP1 PATHWAY TO PROMOTE BREAST CANCER CELL INVASIVENESS IN RESPONSE TO TGFβ12012

    • Author(s)
      Hashimoto A., Hashimoto S., Yoshikawa A., Sugino H., Handa H., Mito S., Sato H., Otsuka Y., Yoshino H., Nam J.M., Onodera Y., Sabe H.
    • Organizer
      The31th Sapporo International Cancer Symposium
    • Place of Presentation
      札幌
    • Year and Date
      2012-06-23
    • Related Report
      2013 Final Research Report
  • [Presentation] 変異p53はArf6活性化経路を介した浸潤獲得形質に必須である2012

    • Author(s)
      橋本あり, 佐邊壽孝
    • Organizer
      第4回シグナルネットワーク研究会
    • Place of Presentation
      大阪
    • Year and Date
      2012-05-18
    • Related Report
      2013 Final Research Report
  • [Presentation] RTKs-GEP100-Arf6-AMAP1 pathway mediates cancerous EMT in response to mutant p53 and TGFβ1 signaling2012

    • Author(s)
      Hisataka Sabe, Ari Hashimoto, Hirokazu Sugino, Ayumu Yoshikawa, Yutaro Otsuka, Haruka Handa, Sizuka Mito, Hiroki Sato, Jin-Min Nam, Yasuhito Onodera and Shigeru Hashimoto
    • Organizer
      第8回OOTR年次学会
    • Place of Presentation
      ウェスティン都ホテル京都(京都市)
    • Related Report
      2012 Research-status Report
  • [Presentation] 変異p53はArf6活性化経路を介した浸潤獲得形質に必須である2012

    • Author(s)
      橋本あり、佐邊壽孝
    • Organizer
      第4回シグナルネットワーク研究会
    • Place of Presentation
      大阪大学微研ホール(吹田市)
    • Related Report
      2012 Research-status Report
  • [Presentation] EZH2 regulates breast cancer invasiveness through GEP100-Arf6-AMAP1 signaling pathway2012

    • Author(s)
      Hirokazu Sugino, Shigeru Hashimoto, Ari Hashimoto, Ayumu Yoshikawa, Haruka Handa, Sizuka Mito, Hisataka Sabe
    • Organizer
      第45回日本発生生物学会・第64回日本細胞生物学会合同大会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Related Report
      2012 Research-status Report
  • [Presentation] EZH2-mediated downregulation of miR-203 generates the ARF6-AMAP1 pathway pivotal for breast cancer invasiveness2012

    • Author(s)
      Hirokazu Sugino, Shigeru Hashimoto, Ari Hashimoto, Ayumu Yoshikawa, Haruka Handa, Hisataka Sabe
    • Organizer
      Beatson International Cancer Conference2012 "Membrane dynamics in cancer"
    • Place of Presentation
      Beatson Institute (UK)
    • Related Report
      2012 Research-status Report
  • [Presentation] MUTANT-p53 GENERATES GEP100-Arf6-AMAP1 PATHWAY TO PROMOTE BREAST CANCER CELL INVASIVENESS IN RESPONSE TO TGFβ12012

    • Author(s)
      Ari Hashimoto, Shigeru Hashimoto, Ayumu Yoshikawa, Hirokazu Sugino, Haruka Handa, Sizuka Mito, Hiroki Sato, Yutaro Otsuka, Hinako Yoshino, Jin-Min Nam, Yasuhito Onodera and Hisataka Sabe
    • Organizer
      第31回札幌国際がんシンポジウム2012
    • Place of Presentation
      北海道大学(札幌市)
    • Related Report
      2012 Research-status Report
  • [Presentation] Mutant-p53 generates GEP100-Arf6-AMAP1 pathway to promote breast cancer cell invasiveness in response to TGFβ12012

    • Author(s)
      Ari Hashimoto, Shigeru Hashimoto, Ayumu Yoshikawa, Hirokazu Sugino, Haruka Handa, Sizuka Mito, Hiroki Sato, Yutaro Otsuka, Hinako Yoshino, Jin-Min Nam, Yasuhito Onodera and Hisataka Sabe
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌(札幌市)
    • Related Report
      2012 Research-status Report
  • [Presentation] EZH2-mediated downregulation of miR-203 generates the Arf6-AMAP1 pathway pivotal for breast cancer invasiveness2012

    • Author(s)
      Hirokazu Sugino,Shigeru Hashimoto, Ari Hashimoto, Yasuhito Onodera, Ayumu Yoshikawa, Yutaro Otsuka, Shizuka Mito, Haruka Handa, Hiroki Sato and Hisataka Sabe
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌((札幌市)
    • Related Report
      2012 Research-status Report
  • [Presentation] GAB1 links c-Met signaling with GEP100-Arf6-AMAP1 pathway to promote breast cancer invasiveness2012

    • Author(s)
      Ayumu Yoshikawa, Shigeru Hashimoto, Ari Hashimoto, Hirokazu Sugino, Yutaro Otsuka, Shizuka Mito, Haruka Handa and Hisataka Sabe
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌(札幌市)
    • Related Report
      2012 Research-status Report
  • [Presentation] beta1 integrin recycling via AMAP1-PRKD2 complex regulated by small GTPases in cancer invasion2012

    • Author(s)
      Yasuhito Onodera, Jin-Min Nam, Ari Hashimoto, Hiroki Shirato, Shigeru Hashimoto and Hisataka Sabe
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌((札幌市)
    • Related Report
      2012 Research-status Report
  • [Presentation] Mutant-p53 generates the GEP100-Arf6-AMAP1 pathway to be activated by TGFβ1 and receptor tyrosine kinases to promote cancer invasion2012

    • Author(s)
      Ari Hashimoto, Shigeru Hashimoto, Ayumu Yoshikawa et al
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Related Report
      2012 Research-status Report
  • [Presentation] EZH2 suppresses miR-203 expression to promote cancer invasion2012

    • Author(s)
      Shigeru Hashimoto, Hirokazu Sugino, Ari Hashimoto, Ayumu Yoshikawa, Yutaro Otsuka, Masanao Yoshino, Haruka Handa and Hisataka Sabe
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Related Report
      2012 Research-status Report
  • [Presentation] Tissue morphogenesis by co-operative regulation of cellular proliferation and migration and diseases due to its breakdown2012

    • Author(s)
      Yasuhito Onodera, Jin-Min Nam, Ari Hashimoto, Mina Bissell, Shigeru Hashimoto, Hisataka Sabe
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Related Report
      2012 Research-status Report
  • [Presentation] Mutant p53 is essential for TGFβ1-induced breast cancer cell invasion via activation of GEP100-Arf6-AMAP1 pathway2011

    • Author(s)
      Hashimoto A. , Hashimoto S., Otsuka Y., Yoshikawa A., Sugino H., Handa H., Sato H., Nam J.M., Shirato H., Fukuda S., Onodera Y., Sabe H.
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-15
    • Related Report
      2013 Final Research Report
  • [Presentation] Mutant p53 is essential for TGFβ1-induced breast cancer cell invasiveness via activation of GEP100-Arf6-AMAP1 pathway2011

    • Author(s)
      Hashimoto A., Hashimoto S., Otsuka Y., Yoshikawa A., Sugino H., Handa H., Nam J.M., Sato H., Fukuda S., Onodera Y., Sabe H.
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-03
    • Related Report
      2013 Final Research Report
  • [Presentation] HGFR/c-Met-mediated activation of GEP100-Arf6-AMAP1 pathway is an integral part for TGFβ-induced cancerous EMT and invasiveness2011

    • Author(s)
      Hashimoto A., Hashimoto S., Otsuka Y., Handa H., Sato H., Sugino H., Yoshikawa A., Umemoto T., Onodera Y., Fukuda S., Sabe H.
    • Organizer
      第63回日本細胞生物学会大会
    • Place of Presentation
      札幌
    • Related Report
      2013 Final Research Report
  • [Presentation] HGFR/c-Met-mediated activation of GEP100-Arf6-AMAP1 pathway is an integral part for TGFβ-induced cancerous EMT and invasiveness2011

    • Author(s)
      Hashimoto A., Hashimoto S., Otsuka Y., Sato H., Sugino H., Yoshikawa A., Umemoto T., Onodera Y., Fukuda S., and Sabe H.
    • Organizer
      第63回 日本細胞生物学会大会
    • Place of Presentation
      北海道大学(札幌市)
    • Related Report
      2011 Research-status Report
  • [Presentation] Mutant p53 is essential for TGFβ1-induced breast cancer cell invasiveness via activation of GEP100-Arf6-AMAP1 pathway2011

    • Author(s)
      Hashimoto A., Hashimoto S., Otsuka Y., Yoshikawa A., Sugino H., Handa H., Nam J.M., Sato H., Fukuda S., Onodera Y., and Sabe H.
    • Organizer
      第70回 日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Related Report
      2011 Research-status Report
  • [Presentation] Mutant p53 is essential for TGFβ1-induced breast cancer cell invasion via activation of GEP100-Arf6-AMAP1 pathway2011

    • Author(s)
      Hashimoto A., Hashimoto S., Otsuka Y., Yoshikawa A., Sugino H., Handa H., Sato H., Nam J.M., Shirato H., Fukuda S., Onodera Y., and Sabe H.
    • Organizer
      第34回 日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2011 Research-status Report
  • [Book] Ras superfamily small G proteins: Biology and Mechanisms2014

    • Author(s)
      Hashimoto S., Hashimoto A., Sugino H., Yoshikawa A., Handa H., Yoshino M., Otsuka Y., and Sabe H.
    • Total Pages
      20
    • Publisher
      Springer Book
    • Related Report
      2013 Annual Research Report
  • [Book] EMT-基礎的観点から,(戸井雅和編:乳癌レビュー2012)2012

    • Author(s)
      橋本あり, 杉野弘和, 橋本茂, 佐邊壽孝
    • Publisher
      メディカルレビュー社
    • Related Report
      2013 Final Research Report
  • [Book] 「EMT-基礎的観点から」乳癌レビュー20122012

    • Author(s)
      橋本あり、杉野弘和、橋本茂、佐邊壽孝
    • Total Pages
      7
    • Publisher
      メディカルレビュー社
    • Related Report
      2012 Research-status Report
  • [Book] 「局所浸潤モデルーがんの浸潤転移に関わる分子装置の解析法」『疾患モデルの作製と利用ーがん』2012

    • Author(s)
      橋本あり、橋本茂、佐邊壽孝
    • Total Pages
      11
    • Publisher
      株式会社エル・アイ・シー
    • Related Report
      2012 Research-status Report
  • [Book] 乳癌レビュー2012 EMT-基礎的観点から2011

    • Author(s)
      橋本 あり、杉野 弘和、橋本 茂、佐邊 壽孝
    • Total Pages
      7
    • Publisher
      メディカルレビュー社
    • Related Report
      2011 Research-status Report
  • [Book] 局所浸潤モデル-がんの浸潤転移に関わる分子装置の解析法(中村卓郎編:疾患モデルの作製と利用)

    • Author(s)
      橋本あり, 橋本茂, 佐邊壽孝
    • Publisher
      エル・アイ・シー(株)
    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.hucc.hokudai.ac.jp/~g21001/index.html

    • Related Report
      2013 Final Research Report
  • [Remarks] 北海道大学 大学院医学研究科 生化学講座 分子生物学分野

    • URL

      http://www.hucc.hokudai.ac.jp/~g21001/index.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 北海道大学 大学院医学研究科 生化学講座 分子生物学分野

    • URL

      http://www.hucc.hokudai.ac.jp/~g21001/index.html

    • Related Report
      2012 Research-status Report
  • [Patent(Industrial Property Rights)] 乳癌乳房温存療法後の局所再発リスクの予測に用いるための診断薬並びに予測方法2013

    • Inventor(s)
      佐邊壽孝, 橋本 茂, 橋本あり, 小野寺康仁, 白土博樹, 木下留美子
    • Industrial Property Rights Holder
      北海道大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-03-04
    • Related Report
      2013 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 放射線治療増強薬及び放射線抵抗性癌の治療方法2013

    • Inventor(s)
      佐邊壽孝, 小野寺康仁, Nam Jin Min, 橋本 茂, 橋本あり
    • Industrial Property Rights Holder
      北海道大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-148970
    • Filing Date
      2013-07-17
    • Related Report
      2013 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 放射線治療増強薬及び放射線抵抗性癌の治療方法2013

    • Inventor(s)
      佐邊壽孝、小野寺康仁、Nam Jin Min、橋本 茂、橋本あり
    • Industrial Property Rights Holder
      佐邊壽孝、小野寺康仁、Nam Jin Min、橋本 茂、橋本あり
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-07-17
    • Related Report
      2013 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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