• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Platelet activation receptor CLEC-2: The role for lung development.

Research Project

Project/Area Number 23590330
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General medical chemistry
Research InstitutionUniversity of Yamanashi

Principal Investigator

INOUE Osamu  山梨大学, 総合研究部, 准教授 (00432154)

Co-Investigator(Renkei-kenkyūsha) INOUE Katsue (SUZUKI Katsue)  山梨大学, 総合研究部, 准教授 (10324211)
TSUKIJI Nagaharu  山梨大学, 総合研究部, 助教 (20710362)
Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
KeywordsCLEC-2 / 血小板 / 肺 / 発生 / myofibroblast / 肺胞上皮 / podoplanin / 肺胞上皮細胞
Outline of Final Research Achievements

The mice deficient in CLEC-2 die just after birth. We found that the newborn mice deficient in CLEC-2 have severe abnormalities in lung structure, and these neonates also have abnormalities in the distribution of myofibroblasts in lung. The conditional knockouts that do not express CLEC-2 on platelets also have these abnormalities in lung, indicating that the CLEC-2 on platelets, but not the CLEC-2 on other hematocytes plays a role in lung development. In vitro study, we confirmed that the granule contents secreted by platelets upon activation facilitate a development of myofibroblasts from lung mesothelial cells. In this study, we clarified the novel mechanism that blood platelets regulate the development of lung through the C-type lectin-like receptor, CLEC-2.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (8 results)

All 2015 2014 Other

All Presentation (7 results) Remarks (1 results)

  • [Presentation] A novel concept for organogenesis: an essential role of platelets in lung development.2015

    • Author(s)
      築地長治
    • Organizer
      第48回日本発生生物学会
    • Place of Presentation
      つくば国際会議場(茨城県つくば市)
    • Year and Date
      2015-06-20 – 2015-06-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Unexpected role of blood platelets in lung development depending on a novel platelet activation receptor, CLEC-22015

    • Author(s)
      築地長治
    • Organizer
      第25回国際血栓止血学会
    • Place of Presentation
      カナダ トロント
    • Year and Date
      2015-06-20 – 2015-06-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Unexpected role of blood platelets in lung development depending on a novel platelet activation receptor, CLEC-22015

    • Author(s)
      築地長治
    • Organizer
      第37回日本血栓止血学会
    • Place of Presentation
      甲府市民会館(山梨県甲府市)
    • Year and Date
      2015-05-21 – 2015-05-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Unexpected role of blood platelets in lung development depending on a novel platelet activation receptor, CLEC-22015

    • Author(s)
      築地長治
    • Organizer
      第9回AIM
    • Place of Presentation
      ホテルグリーンピア南阿蘇(熊本県阿蘇郡)
    • Year and Date
      2015-05-14 – 2015-05-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] Unexpected role of blood platelets in lung development depending on a novel platelet activation receptor, CLEC-22015

    • Author(s)
      築地長治
    • Organizer
      TGF-βファミリーシグナル国際共同研究拠点 第4回国際シンポジウム
    • Place of Presentation
      つくば国際会議場(茨城県つくば市)
    • Year and Date
      2015-01-12 – 2015-01-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Unexpected role of blood platelets in lung development depending on a novel platelet activation receptor, CLEC-22014

    • Author(s)
      築地長治
    • Organizer
      第47回日本発生生物学会
    • Place of Presentation
      ウインク愛知(愛知県名古屋市)
    • Year and Date
      2014-05-27 – 2014-05-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] Unexpected role of blood platelets in lung development depending on a novel platelet activation receptor, CLEC-22014

    • Author(s)
      築地 長治
    • Organizer
      第47回日本発生生物学会
    • Place of Presentation
      愛知県名古屋市 ウィンクあいち
    • Related Report
      2013 Research-status Report
  • [Remarks] 山梨大学大学院医学工学総合研究部 臨床検査医学講座のホームページ

    • URL

      http://www.med.yamanashi.ac.jp/clinical/clin0lab/

    • Related Report
      2012 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi