Analyses of factors acting with Parkinson's disease gene LRRK2 using nematode as a model organism
Project/Area Number |
23590331
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General medical chemistry
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Research Institution | Nagoya University |
Principal Investigator |
HISAMOTO Naoki 名古屋大学, 理学(系)研究科(研究院), 准教授 (80283456)
|
Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | 細胞内シグナル伝達 / LRRK2 / C. elegans / パーキンソン病 / C.エレガンス / LRK-1 / Cエレガンス |
Research Abstract |
It is known that mutations in LRRK2 are linked to both sporadic and familial Parkinson's disease in human. We identified two human proteins that bind to LRRK2: BAG-2 and HSC70, which are known to form a chaperone complex. In addition, we characterized that their C. elegans homologs, UNC-23 and HSP-1, regulate polarized sorting of synaptic vesicle proteins by determining Golgi localization of LRK-1, the sole homolog of human LRRK. Furthermore, we demonstrated that LRK-1 acts with p38 MAP kinase pathway to protect C. elegans dopaminergic neurons from 6-OHDA toxicity.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Dysregulated LRRK2 signaling in response to endoplasmic reticulum stress leads to dopaminergic neuron degeneration in C. elegans2011
Author(s)
Yuan, Y., Cao, P., Smith, M. A., Kramp, K., Huang, Y., Hisamoto, N., Matsumoto, K., Hatzoglou, M., Jin, H., and Feng, Z
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Journal Title
PLoS One
Volume: 6
Issue: 8
Pages: e22354-e22354
DOI
Related Report
Peer Reviewed
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[Journal Article] Regulation of anoxic death in Caenorhabditis elegans by mammalian apoptosis signal-regulating kinase (ASK) family proteins2011
Author(s)
Hayakawa, T., Kato, K., Hayakawa, R., Hisamoto, N., Matsumoto, K., Takeda, K. and Ichijo, H.
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Journal Title
Genetics
Volume: 187
Issue: 3
Pages: 785-792
DOI
Related Report
Peer Reviewed
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[Journal Article] The C. elegans JIP3 protein UNC-16 functions as an adaptor to link kinesin-1 with cytoplasmic dynein2011
Author(s)
Arimoto, M., Koushika, S. P., Choudhary, B. C., Li, C., Matsumoto, K., and Hisamoto, N
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Journal Title
J. Neurosci
Volume: 31
Issue: 6
Pages: 2216-2224
DOI
Related Report
Peer Reviewed
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