| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
It is known that mutations in LRRK2 are linked to both sporadic and familial Parkinson's disease in human. We identified two human proteins that bind to LRRK2: BAG-2 and HSC70, which are known to form a chaperone complex. In addition, we characterized that their C. elegans homologs, UNC-23 and HSP-1, regulate polarized sorting of synaptic vesicle proteins by determining Golgi localization of LRK-1, the sole homolog of human LRRK. Furthermore, we demonstrated that LRK-1 acts with p38 MAP kinase pathway to protect C. elegans dopaminergic neurons from 6-OHDA toxicity.
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