Pleiotropic effects of afadin, an scaffold molecule, on regulation of cellular functions
| Project/Area Number |
23590335
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 細胞医化学 / 細胞接着 / 細胞運動 / 低分子量Gタンパク質 / シグナル伝達 / 細胞形態 / 脈管構造 |
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| Research Abstract |
Afadin has pleiotropic cellular functions including cell adhesion, cell migration and cell polarization. However, its molecular mechanisms in these phenomena, especially cell migration and polarization, remain elusive. In this research project, the DIL domain of afadin was found to play pivotal roles in the formation of cell polarity during cell migration. The DIL domain binding molecule ADIP crucially mediated the activation of small G protein Rac. Afadin conditional knockout mice specifically in cardiomyocytes or endothelial cells were generated successfully. From the experiments using these mice, afadin was involved in the progression of cardiac hypertrophy and in the regulation of lymphatic vessel morphology.
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Report
(4 results)
Research Products
(32 results)
