Identification of novel biological functions of fetal Leydig cells
| Project/Area Number |
23590339
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Kyushu University |
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Principal Investigator |
SHIMA YUICHI 九州大学, 医学(系)研究科(研究院), 助教 (80425420)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ライディッヒ細胞 / トランスクリプトーム / 男性ホルモン / ノックアウトマウス / 核内受容体 / 分化 / ステロイドホルモン |
|---|
| Research Abstract |
Leydig cells synthesize androgens, and thus they are essential for masculinization of the whole body. It is known that there are two type of Leydig cells, fetal leydig cells and adult Leydig cells, in the mammalian testis. However, functional differences between these two cell populations were not clarified yet. Moreover, the origin and functional importance of fetal Leydig cells were not defined at all.
In this study, we idenified that gene expression profiles are quite different between two types of Leydig cells, and they produce different types of androgens. In addition, we have identified novel functions of fetal Leydig cells by disrupting a gene specifically in the fetal Leydig cells.
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] Glycolytic genes are targets of the nuclear receptor Ad4BP/SF-1.2014
Author(s)
Baba T, Otake H, Sato T, Miyabayashi K, Shishido Y, Wang CY, Shima Y, Kimura H, Yagi M, Ishihara Y, Hino S, Ogawa H, Nakao M, Yamazaki T, Kang D, Ohkawa Y, Suyama M, Chung BC, Morohashi K
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Journal Title
Nature Commun
Volume: 5
Pages: 3634-3634
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Cbx2, a polycomb group gene, is required for Sry gene expression in mice2012
Author(s)
Katoh-Fukui Y, Miyabayashi K, Komatsu T, Owaki A, Baba T., Shima, Y, Kidokoro T, Kanai Y, Schedl A, Wilhelm D, Koopman P, Okuno Y, Morohashi K.
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Journal Title
Endocrinology
Volume: 153(2)
Pages: 913-24
DOI
Related Report
Peer Reviewed
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[Presentation] 胎仔型ライディッヒ細胞の細胞運命と機能2013
Author(s)
嶋雄一, 宮林香奈子, 松崎佐和子, 井上実紀, 馬場崇, 大竹博之, 諸橋憲一郎
Organizer
第18回日本生殖内分泌学会学術集会
Place of Presentation
東京砂防会館別館(シェーンバッハ・サボー)(口頭発表・学術奨励賞受賞)
Year and Date
2013-12-07
Related Report
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[Presentation] Effect of fetal Leydig cell-specific Ad4BP/SF-1 gene disruption on masculinization and spermatogenesis2012
Author(s)
Yuichi Shima, Kanako Miyabayashi, Takashi Baba, Hiroyuki Otake, Kentaro Suzuki, Shogo Haraguchi, Kazuyoshi Tsutsui and Ken-ichiroui Morohashi
Organizer
The 58th/60th NIBB Conference, Germline –Specification, sex, and stem cells-
Place of Presentation
Okazaki, Japan
Related Report
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