Regulation of tumor angiogenesis and metastasis, and postischemic angiogenesis by sphingosine-1-phosphate signaling system
Project/Area Number |
23590344
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General medical chemistry
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Research Institution | Ishikawa Prefectural Nursing University |
Principal Investigator |
TAKUWA Noriko 石川県立看護大学, 看護学部, 教授 (70150290)
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Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | 脂質メディエーター / がん血管新生 / 虚血後血管新生 / スフィンゴシンキナーゼ / G蛋白共役型受容体 / リゾリン脂質メディエーター / Gタンパク共役型受容体 / スフィンゴ脂質 / 末梢動脈疾患 / スフィンゴシン-1-リン酸 / S1P2 / がん血行性転移 |
Research Abstract |
The sphingosine-1-phosphate receptor S1PR2 is the first G protein-coupled receptor that negatively regulates cell migration through inhibition of Rac downstream of G12/13-Rho. S1PR2 expressed in tumor cells mediates inhibition of cell migration and invasion in vitro and hematogenous metastasis in vivo. S1PR2 expressed in host vascular endothelial cells and bone marrow-derived myeloid cells together mediate inhibition of tumor angiogenesis and tumor growth in vivo. We studied the roles of host S1PR2 in metastasis and post-ischemic angiogenesis and found interesting results. We also tested a widely accepted concept that sphingosine kinase 1 (SphK1), a major S1P synthesizing enzyme, plays an causative role in cancer development, by comparing incidence of malignancies between SphK1 transgenic mice and their littermates. We found no difference in incidence of either spontaneous or ENU (a mutagen)-induced tumor development between SphK1 transgenic and littermate wild type mice.
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Report
(4 results)
Research Products
(68 results)
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[Journal Article] Essential role of endothelial class II PI3K-C2αin angiogenesis and vascular barrier function2012
Author(s)
Yoshioka K, Yoshida K, Cui H, Wakayama T, Takuwa N, Okamoto Y, Du W, Qi X, Asanuma K, Sugihara K, Aki S, Miyazawa H, Biswas K, Nagakura C, Ueno M, Iseki S, Schwartz JR, Okamoto H, Sasaki T,Matsui O, Asano M, Adams HR, Takakura N, Takuwa Y.
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Journal Title
Nature med
Volume: 18
Issue: 10
Pages: 1560-1569
DOI
Related Report
Peer Reviewed
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[Presentation] スフィンゴシン1-リン酸特異的2型受容体は内皮型一酸化窒素合成酵素を抑制することによりアナフィラキシーショックに対して保護的に働く2013
Author(s)
崔弘, 岡本安雄, 吉岡和晃, 杜娃, 多久和典子, 張威, Kuntal Biswas, 安藝翔, 趙娟娟, 九田裕一, 浅野雅秀, 芝本利重, 多久和陽
Organizer
第90回日本生理学会
Place of Presentation
タワーホール船堀(東京)
Related Report
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