Roles of oxidized LDL receptor and TLR4 signaling in lung metastasis
| Project/Area Number |
23590347
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
TOMITA Takeshi 東京女子医科大学, 医学部, 助教 (20302242)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 血清アミロイドA3 / 酸化LDL受容体 / TLR4 / 血清アミロイド / S100A8 |
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| Research Abstract |
Tumor metastasis happens results of various steps including formation of pre-matastatic phase. In the pre-metastatic lungs, accumulations of myeloid derived suppressor cells and upregulations of S100A8 and SAA3 expressions have been observed, but detailed molecular mechanisms are not fully understood. This study focused on oxidized LDL receptor and TLR/MD-2 complex, both express in lung endothelial cells and epithelial cells in relation with their potential endogenous ligands, S100A8 and SAA3. By using purified proteins and overexpression sytems, the research identified that SAA3 binds MD-2 but not TLR4. In addition certain SAA3 variant binds oxidized LDL receptor.
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Report
(4 results)
Research Products
(14 results)
