Studies on the novel factor in the renin-angiotensin system in the pathophysiology of the cardio-renal anemia syndrome
| Project/Area Number |
23590352
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
戸恒 和人 東北福祉大学, 総合福祉学部, 教授 (10217515)
金子 桐子 東北大学, 大学院医学系研究科, 助教 (10545784)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | プロレニン受容体 / 赤芽球 / インターフェロン-γ / エリスロポエチン / トリヨードサイロニン / 腎性貧血 / アンジオテンシン / V-ATPase / プロレニン / 受容体 / 貧血 / 心不全 / 腎不全 / prorenin receptor / erythroid cells / erythropiesis / YN-1 / angiotensin / renin |
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| Research Abstract |
Prorenin receptor is a specific receptor for renin and prorenin. We have shown expression of prorenin receptor in cultured erythroid cells, YN-1 cells and YN-1-0A cells. Interferon-gamma, erythropoietin and triiodothyronine affected its expression levels. Prorenin receptor stimulates cell proliferation. These findings have raised the possibility that prorenin receptor is related to erythropoiesis and may play some pathophysiological roles in anemia, such as renal anemia.
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] Ass2011
Author(s)
Hirose T, Hashimoto M, Totsune K, Metoki H, Hara A, Satoh M, Kikuya M, Ohkubo T, Asayama K, Kondo T, Kamide K, Katsuya T, Ogihara T, Izumi S, Rakugi H, Takahashi K, Imai Y.
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Journal Title
Hypertens Resociation of (pro)renin receptor gene polymorphisms with lacunar infarction and left ventricular hypertrophy in Japanese women : the Ohasama study
Volume: 34
Issue: 4
Pages: 530-535
DOI
Related Report
Peer Reviewed
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[Journal Article] Influence of adrenomedullin 2/intermedin gene polymorphism on blood pressure, renal function and silent cerebrovascular lesions in Japanese : the Ohasama study2011
Author(s)
Hirose T, Totsune K, Nakashige Y, Metoki H, Kikuya M, Ohkubo T, Hara A, Satoh M, Inoue R, Asayama K, Kondo T, Kamide K, Katsuya T, Ogihara T, Izumi Shin-Ichi, Rakugi H, Takahashi K and Imai Y.
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Journal Title
Hypertens Res
Volume: 34
Issue: 12
Pages: 1327-1332
DOI
NAID
Related Report
Peer Reviewed
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[Presentation] (Pro)renin receptor in breast carcinoma2013
Author(s)
Ohba K, Nishiyama H, Kaneko K, Hirose T, Totsune K, Sasano H, Suzuki T, Takahashi K
Organizer
International symposium of aldosterone and related substances in hypertension 2013 (ISARSH2013)
Place of Presentation
仙台
Related Report
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[Presentation] Neuropeptides and cardiovascular regulation.2012
Author(s)
Takahashi K, Kaneko K, Totsune K.
Organizer
The 3rd Meeting of the Japan Branch of the International Neuropeptide Society (INPS). International Symposium: Frontiers in Biologically Active Peptide Research.
Place of Presentation
北九州
Related Report
Invited
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[Book] Urotensin peptides. In Handbook of Biologically Active Peptides Second Edition. Kastin AJ, ed.2013
Author(s)
Takahashi K, Totsune K
Publisher
Elsevier, Amsterdam, Boston, Heidelberg, London, New York, Oxford, Paris, San Diego, San Francisco, Singapore, Sydney, Tokyo
Related Report
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