| Project/Area Number |
23590352
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
戸恒 和人 東北福祉大学, 総合福祉学部, 教授 (10217515)
金子 桐子 東北大学, 大学院医学系研究科, 助教 (10545784)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | プロレニン受容体 / 赤芽球 / インターフェロン-γ / エリスロポエチン / トリヨードサイロニン / 腎性貧血 / アンジオテンシン / V-ATPase / プロレニン / 受容体 / 貧血 / 心不全 / 腎不全 / prorenin receptor / erythroid cells / erythropiesis / YN-1 / angiotensin / renin |
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| Research Abstract |
Prorenin receptor is a specific receptor for renin and prorenin. We have shown expression of prorenin receptor in cultured erythroid cells, YN-1 cells and YN-1-0A cells. Interferon-gamma, erythropoietin and triiodothyronine affected its expression levels. Prorenin receptor stimulates cell proliferation. These findings have raised the possibility that prorenin receptor is related to erythropoiesis and may play some pathophysiological roles in anemia, such as renal anemia.
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