| Project/Area Number |
23590358
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Mie University |
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Principal Investigator |
SUZUKI NOBORU 三重大学, 生命科学研究支援センター, 准教授 (00202135)
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| Co-Investigator(Kenkyū-buntansha) |
OIKAWA Shinji 三重大学, 医学系研究科, 准教授 (10277006)
SAITO Hiromitsu 三重大学, 生命科学研究支援センター, 助教 (50303722)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 癌性カヘキシア / 悪液質 / 癌モデル動物 / K-ras / IL-6 / BNP / PTHｒP / 癌性悪液質 / 癌随伴性症候群 / 遺伝子改変動物 / ras癌遺伝子 / 脳性ナトリウム利尿ペプチド / 副甲状腺ホルモン関連蛋白 / インターロイキン６ / がん性カヘキシア / モデル動物 / カヘキシア誘導能 / がん宿主相互作用 / FoxN1 |
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| Research Abstract |
We have identified an oncogenic K-rasG12V conditional tumor mouse model as both a pleomorphic rhabdomyosarcoma and a cancer cachexia model when K-rasG12V is specifically expressed in skeletal musculature cells. We have elucidated crucial roles of Interleukin-6 (IL-6), one of major inflammatory cytokines, and brain natriuretic peptide (BNP) and parathyroid hormone-related protein in the pathogenesis of cancer cachexia through phenotypic characterization of whole bodies that are inoculated with tumor-derived cell lines and analysis of induced tumors.
Furthermore, We have suggested forkhead box N1, one of the forkhead family or "winged-helix" transcription factors, as one of cachexia-sensitive factors for the tumor bearing individual.
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