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Reproduction of pancreatic islet in the pancreas by gene therapy

Research Project

Project/Area Number 23590378
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Human genetics
Research InstitutionShiga University of Medical Science

Principal Investigator

KOJIMA HIDETO  滋賀医科大学, 医学部, 准教授 (00225434)

Co-Investigator(Kenkyū-buntansha) KIMURA Hiroshi  滋賀医科大学, 医学部, 名誉教授 (00110560)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords遺伝子治療 / 膵島 / インスリン / 糖尿 / 再生医療 / 糖尿病 / 国際情報交換 / アメリカ合衆国
Research Abstract

For the treatment of a mouse model of insulin-dependent diabetes mellitus, we used nanodiamonds to deliver DNA for gene-therapy aiming the differentiation of the pancreatic islet from progenitor cells localized in the pancreatic duct epithelium. By an application of plasmid DNA coding a fluorescent dye we clearly observed the dye expression at the position of pancreatic duct, indicating that the vector system performed its role for gene delivery to the pancreatic ducts. Next, we need to examine the usefulness of the vector in the pancreatic islet regeneration.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report

Research Products

(21 results)

All 2014 2013 2012 Other

All Journal Article Presentation

  • [Journal Article] Emerging roles of hematopoietic cells in the pathobiology of diabetic complications2014

    • Author(s)
      Kojima H, Kim J, Chan L
    • Journal Title

      Trends Endocrinolo Metab

      Volume: vol.25 Pages: 178-187

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hyperglycemia induces abnormal gene expression in hematopoietic stem cells and their progeny in diabetic neuropathy2014

    • Author(s)
      Katagi M, Terashima T, Okano J, Nakae Y, Ogawa N, Udagawa J, Maegawa H, Matsumura K, Chan L, Kojima H
    • Journal Title

      FEBS Lett

      Volume: Vol 588 Pages: 1080-1086

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Emerging roles of hematopoietic cells in the pathobiology of diabetic complications.2014

    • Author(s)
      Kojima H, Kim J, Chan L.
    • Journal Title

      Trends Endocrinol Metab

      Volume: 25 Pages: 178-187

    • DOI

      10.1016/j.tem.2014.01.002

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hyperglycemia induces abnormal gene expression in hematopoietic stem cells and their progeny in diabetic neuropathy.2014

    • Author(s)
      Katagi M, Terashima T, Okano J, Urabe H, Nakae Y, Ogawa N, Udagawa J, Maegawa H, Matsumura K, Chan L, Kojima H.
    • Journal Title

      FEBS Lett.

      Volume: 588 Pages: 1080-1086

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 糖尿病合併症を誘導する異常骨髄細胞の同定と新規治療薬の開発2013

    • Author(s)
      小島秀人, 樫美和子, 寺島智也, 前川聡, 木村博
    • Journal Title

      滋賀貴台雑誌

      Volume: 26巻

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 糖尿病合併症を誘導する異常骨髄幹細胞の同定と新規治療薬の開発2013

    • Author(s)
      小島秀人, 樫美和子, 寺島智也, 前川聡, 木村博
    • Journal Title

      滋賀医大雑誌

      Volume: 26

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Haematopoietic cells produce BDNF and regulate appetite upon migration to the hypothalamus2013

    • Author(s)
      H Urabe, H Kojima, L Chan, T Terashima, N Ogawa, M Katagi, K Fujino, A Kumagai, H Kawai, A Asakawa, A Inui, H Yasuda, Y Eguchi, K Oka, H Maegawa, A kashiwagi, H Kimura
    • Journal Title

      Nat Commun

      Volume: 4 Pages: 1526-1526

    • DOI

      10.1038/ncomms2536

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 骨髄移植に際する放射線照射が表皮組織に与える影響2014

    • Author(s)
      岡野純子, 小島秀人, 樫美和子, 中江由希, 寺島智也, 小川暢弘, 浦部博志, 宇田川潤
    • Organizer
      再生医療学会
    • Place of Presentation
      京都国際会館
    • Year and Date
      2014-03-05
    • Related Report
      2013 Final Research Report
  • [Presentation] 糖尿病性神経障害を誘導する異常な骨髄幹細胞の同定2014

    • Author(s)
      樫美和子, 小島秀人, 中江由希, 寺島智也, 岡野純子, 宇田川潤, 前川聡, 宇田川潤
    • Organizer
      再生医療学会
    • Place of Presentation
      京都国際会館
    • Year and Date
      2014-03-05
    • Related Report
      2013 Final Research Report
  • [Presentation] TNFα発現抑制による脊髄後根神経細胞保護作用を介した神経因性疼痛への遺伝子治療2014

    • Author(s)
      小川暢弘, 寺島智也, 川合寛道, 小島秀人, Kazuhiro Oka, Lawrence Chan, 前川聡
    • Organizer
      再生医療学会
    • Place of Presentation
      京都国際会館
    • Year and Date
      2014-03-05
    • Related Report
      2013 Final Research Report
  • [Presentation] ナノダイヤモンドを用いた膵管上皮への遺伝子輸送システムの開発2014

    • Author(s)
      小島秀人, 中江由希, Li Zhao, 樫美和子, 寺島智也, 岡野純子, 小松直樹, 宇田川潤, 前川聡
    • Organizer
      再生医療学会
    • Place of Presentation
      京都国際会館
    • Year and Date
      2014-03-04
    • Related Report
      2013 Final Research Report
  • [Presentation] 標的化ナノダイヤモンドベクターの開発:DRG神経細胞への遺伝子輸送ベクター2014

    • Author(s)
      中江由希, 小島秀人, 寺島智也, 小川暢弘, 岡野純子, Zhao Li, 小松直也, 前川聡
    • Organizer
      再生医療学会
    • Place of Presentation
      京都国際会館
    • Year and Date
      2014-03-04
    • Related Report
      2013 Final Research Report
  • [Presentation] 糖尿病にともなう過食に対する骨髄幹細胞の分化異常の関与2013

    • Author(s)
      小島秀人, 樫美和子, 中江由希, 寺島島智也, 前川聡
    • Organizer
      エピジェネティクス研究会
    • Place of Presentation
      奈良県新公会堂
    • Year and Date
      2013-05-31
    • Related Report
      2013 Final Research Report
  • [Presentation] 高血糖メモリーの解明ー骨髄におけるヒストンデアセチラーゼの発現ー2012

    • Author(s)
      小島秀人、樫美和子、木村博
    • Organizer
      第6回日本エピジェネティクス研究会年会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 糖尿病における骨髄幹細胞の分化異常ーTNF-alphaの発現とヒストンデアセチラーゼについてー2012

    • Author(s)
      樫美和子、小島秀人、木村博
    • Organizer
      第11回日本再生医療学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] ナノダイヤモンドを用いた 膵管上皮への遺伝子輸送システムの開発

    • Author(s)
      小島秀人・中江由希・Li Zhao・樫美和子・寺島智也・岡野純子・小松直樹・宇田川潤・前川聡
    • Organizer
      再生医療学会
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2013 Annual Research Report
  • [Presentation] 標的化ナノダイヤモンドベクターの開発:DRG神経細胞への遺伝子 輸送ベクター

    • Author(s)
      中江由希・小島秀人・寺島智也・樫美和子・小川暢弘・岡野純子・Zhao Li・小松直樹・前川聡
    • Organizer
      再生医療学会
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2013 Annual Research Report
  • [Presentation] 骨髄移植に際する放射線照射が表皮組織に与える影響

    • Author(s)
      岡野純子・小島秀人・樫美和子・中江由希・寺島智也・小川暢弘・浦部博志・宇田川潤
    • Organizer
      再生医療学会
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2013 Annual Research Report
  • [Presentation] 糖尿病性神経障害を誘導する異常な骨髄幹細胞の同定

    • Author(s)
      樫美和子・小島秀人・中江由希・寺島智也・岡野純子・宇田川潤・前川聡
    • Organizer
      再生医療学会
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2013 Annual Research Report
  • [Presentation] TNFα発現抑制による脊髄後根神経細胞保護作用を介した神経因性疼痛への遺伝子治療

    • Author(s)
      小川暢弘・寺島智也・川合寛道・小島秀人・Kazuhiro Oka・Lawrence Chan・前川聡
    • Organizer
      再生医療学会
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2013 Annual Research Report
  • [Presentation] 糖尿病にともなう過食に対する骨髄幹細胞の分化異常の関与

    • Author(s)
      小島秀人・樫美和子・中江由希・寺島智也・前川聡
    • Organizer
      エピジェネティクス研究会
    • Place of Presentation
      奈良県新公会堂
    • Related Report
      2013 Annual Research Report

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Published: 2011-08-04   Modified: 2019-07-29  

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