Reproduction of pancreatic islet in the pancreas by gene therapy
| Project/Area Number |
23590378
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human genetics
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
KOJIMA HIDETO 滋賀医科大学, 医学部, 准教授 (00225434)
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| Co-Investigator(Kenkyū-buntansha) |
KIMURA Hiroshi 滋賀医科大学, 医学部, 名誉教授 (00110560)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 遺伝子治療 / 膵島 / インスリン / 糖尿 / 再生医療 / 糖尿病 / 国際情報交換 / アメリカ合衆国 |
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| Research Abstract |
For the treatment of a mouse model of insulin-dependent diabetes mellitus, we used nanodiamonds to deliver DNA for gene-therapy aiming the differentiation of the pancreatic islet from progenitor cells localized in the pancreatic duct epithelium. By an application of plasmid DNA coding a fluorescent dye we clearly observed the dye expression at the position of pancreatic duct, indicating that the vector system performed its role for gene delivery to the pancreatic ducts. Next, we need to examine the usefulness of the vector in the pancreatic islet regeneration.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Hyperglycemia induces abnormal gene expression in hematopoietic stem cells and their progeny in diabetic neuropathy.2014
Author(s)
Katagi M, Terashima T, Okano J, Urabe H, Nakae Y, Ogawa N, Udagawa J, Maegawa H, Matsumura K, Chan L, Kojima H.
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Journal Title
FEBS Lett.
Volume: 588
Pages: 1080-1086
Related Report
Peer Reviewed
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[Journal Article] Haematopoietic cells produce BDNF and regulate appetite upon migration to the hypothalamus2013
Author(s)
H Urabe, H Kojima, L Chan, T Terashima, N Ogawa, M Katagi, K Fujino, A Kumagai, H Kawai, A Asakawa, A Inui, H Yasuda, Y Eguchi, K Oka, H Maegawa, A kashiwagi, H Kimura
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Journal Title
Nat Commun
Volume: 4
Pages: 1526-1526
DOI
Related Report
Peer Reviewed
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