Bach1 as a therapeutic target for ischemic cardiovascular diseases

• Project/Area Number: 23590381
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human genetics
• Research Institution: Hiroshima University
• Principal Investigator: ISHIDA Takafumi 広島大学, 医歯薬保健学研究院(医), 講師 (40346482)
• Co-Investigator(Kenkyū-buntansha): ISHIDA Mari 広島大学, 大学院医歯薬保健学研究院, 講師 (30359898)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 心血管疾患 / RNA干渉 / 酸化ストレス / 酸化ストレス応答 / 虚血

Research Abstract

Bach1 is a stress-responsive transcriptional factor that orchestrates the expression levels of cytoprotective factors, including heme-oxygenase (HO)-1. In the present study, we investigated the effect of suppression of Bach1 expression on cardiac remodeling after myocardial infarction and limb ischemia in mice. Adverse cardiac remodeling and fibrosis after myocardial infarction was significantly attenuated in Bach1-deficient mice. Intramuscular administration of siRNA against Bach1 accelerated blood flow perfusion and capillary density in a hindlimb ischemia model. These results suggest that Bach1 expression can be a therapeutic target in ischemic cardiovascular diseases.

Research Products

• [Journal Article] Reorganization of damaged chromatin by the exchange of histone variant H2A.Z-2. (2014)
  • Author(s): Nishibuchi I, Suzuki H, Kinomura A, Sun J, Liu N-A, Horikoshi Y, Shima H, Kusakabe M, Harata M, Fukagawa T, Ikura T, Ishida T, Nagata Y and Tashiro S
  • Journal Title: Int. J Radiation Oncol Biol Phys. Volume: 89/90
  • Peer Reviewed
• [Journal Article] Role of DNA damage in cardiovascular disease (2013)
  • Author(s): Ishida T, Ishida M, Tashiro S, Yoshizumi M, Kihara Y
  • Journal Title: Circ J Volume: 78 Pages: 42-50
  • NAID: 130003382191
  • Peer Reviewed
• [Journal Article] Induction of Timp1 in smooth muscle cells during development of abdominal aortic aneurysms (2013)
  • Author(s): Bumdelger B, Kokubo H, Kamata R, Fujii M, Ishida M, Ishida T, Yoshizumi M
  • Journal Title: Hiroshima J Med Sci Volume: 62 Pages: 63-67
  • NAID: 120005396042
  • Peer Reviewed
• [Journal Article] Role of DNA damage in cardiovascular disease. (2013)
  • Author(s): Ishida T, Ishida M, Tashiro M, Yoshizumi M, and Kihara Y
  • Journal Title: Circulation J. Volume: 78 Pages: 42-50
  • NAID: 130003382191
  • Peer Reviewed
• [Journal Article] Induction of Timp1 in smooth muscle cells during development of abdominal aortic aneurysms. (2013)
  • Author(s): Bumdelger B, Kokubo H, Kamata R, Fujii M, Ishida M, Ishida T and Yoshizumi M
  • Journal Title: Hiroshima J Med Sci Volume: 62 Pages: 63-67
  • NAID: 120005396042
  • Peer Reviewed
• [Journal Article] Association of elevated plasma aldosterone-to-renin ratio with future cardiovascular events in patients with essential hypertension (2012)
  • Author(s): Kisaka T, Ozono R, Ishida T, Higashi Y, Oshima T, Kihara Y
  • Journal Title: J Hypertens Volume: 30 Pages: 2322-2330
  • Peer Reviewed
• [Journal Article] Association of elevated plasma aldosterone-to-renin ratio with future cardiovascular events in patients with essential hypertension. (2012)
  • Author(s): Kisaka T, Ozono R, Ishida T, Higashi Y, Oshima T, Kihara Y
  • Journal Title: J. Hypertens. Volume: 30 Issue: 12 Pages: 2322-2330
  • DOI: 10.1097/hjh.0b013e328359862d
  • Peer Reviewed
• [Journal Article] Species differences of macrophage very low-density-lipoprotein (VLDL) receptor protein expression (2011)
  • Author(s): Takahashi S, Ito T, Zenimaru Y, Suzuki J, Miyamori I, Takahashi M, Ishida T, Hirata K, Yamamoto TT, Iwasaki T, Hattori H, Shiomi M
  • Journal Title: Biochem Biophys Res Commun Volume: 407 Pages: 656-662
  • Peer Reviewed
• [Journal Article] Species differences of macrophage very low-density-lipoprotein (VLDL) receptor protein expression. (2011)
  • Author(s): Takahashi S, Ito T, Zenimaru Y, Suzuki J, Miyamori I, Takahashi M, Takahashi M, Ishida T, Ishida T, Hirata K, Yamamoto TT, Iwasaki T, Hattori H, Shiomi M
  • Journal Title: Biochem Biophys Res Commun. Volume: 407 Pages: 652-662
  • Peer Reviewed
• [Journal Article] Reorganization of Damaged Chromatin by the Exchange of Histone Variant H2A.Z-2
  • Author(s): Nishibuchi I, Suzuki H, Kinomura A, Sun J, Liu N-A, Horikoshi Y, Shima H, Kusakabe M, Harata M, Fukagawa T, Ikura T, Ishida T, Nagata Y, Tashiro S
  • Journal Title: Int Journal Radiation Oncol Biol Phys Volume: (in press)
  • Peer Reviewed
• [Presentation] The effect of ezetimibe on lipid and glucose metabolism in patients with hypercholesterolemia. (2013)
  • Author(s): 石田 隆史
  • Organizer: 第45回日本動脈硬化学会学術集会
  • Place of Presentation: 東京
• [Presentation] Cigarette smoking induces DNA double strand breaks in human mononuclear cells. (2013)
  • Author(s): Ishida T, Ishida M, Tashiro S, Uchida H, Sakai C, Kawashima A, Chayama K, Yoshizumi M, Kihara Y
  • Organizer: 3rd International Symposium of RIRBM
  • Place of Presentation: Hiroshima, Japan
• [Presentation] Oxidative stress induces DNA double-strand breaks and activates DNA damage response in vascular smooth muscle cells (2011)
  • Author(s): Takafumi Ishida, Mari Ishida, Satoshi Tashiro, Chiemi Sakai, Hitomi Uchida, Kiyoshi Miyagawa, Masao Yoshizumi, Yasuki Kihara
  • Organizer: A possible mechanism for atherosclerosis progression American Heart Association Basic Cardiovascular Sciences 2011 Scientific Sessions, New Orleans
  • Place of Presentation: LA, USA
• [Presentation] Oxidative Stress Induces DNA Double Strand Breaks and Activates DNA Damage Responses in Vascular Smooth Muscle Cells: A Possible Mechanism for Atherosclerosis Progression (2011)
  • Author(s): Takafumi Ishida
  • Organizer: American Heart Association Basic Cardiovascular Sciences 2011 Scientific Sessions
  • Place of Presentation: New Orleans, USA