Genome-wide association study of high myopia using multiple ethnic groups
| Project/Area Number |
23590382
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human genetics
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| Research Institution | Yokohama City University |
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Principal Investigator |
NOMURA Naoko 横浜市立大学, 医学部, 助教 (40537205)
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| Co-Investigator(Kenkyū-buntansha) |
MIZUKI Nobuhisa 横浜市立大学, 医学研究科, 教授 (90336579)
MEGURO Akira 横浜市立大学, 医学研究科, 特任講師 (60508802)
KAWAGOE Tatsutaka 横浜市立大学, 医学部, 助教 (20564800)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 近視 / 遺伝子 / 国際情報交流（中国、台湾、シンガポール） |
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| Research Abstract |
In this study, we performed a genome-wide association study (GWAS) of high myopia using multiple ethnic groups (Japanese, Taiwanese, Chinese, Chinese Singaporean) and identified two genetic loci showing a significant association with the risk of high myopia in all ethnic groups. Our genetic findings may lead to clarify a pathogenic mechanism of high myopia.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.2013
Author(s)
Cheng CY, Schache M, Ikram MK, Young TL, Guggenheim JA, Vitart V, MacGregor S, Verhoeven VJ, Barathi VA, Liao J, Hysi PG, Bailey-Wilson JE, St Pourcain B, Kemp JP, McMahon G, Timpson NJ, Evans DM, Montgomery GW, Meguro A, Mizuki N, et al
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Journal Title
Am J Hum Genet
Volume: 93(2)
Issue: 2
Pages: 264-277
DOI
Related Report
Peer Reviewed
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[Journal Article] Targeted resequencing implicates the familial Mediterranean fever gene MEFV and the toll-like receptor 4 gene TLR4 in Behçet disease.2013
Author(s)
Kirino Y, Zhou Q, Ishigatsubo Y, Mizuki N, Tugal-Tutkun I, Seyahi E, Özyazgan Y, Ugurlu S, Erer B, Abaci N, Ustek D, Meguro A, Ueda A, Takeno M, Inoko H, Ombrello MJ, Satorius CL, Maskeri B, Mullikin JC, Sun HW, et al
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Journal Title
Proc Natl Acad Sci U S A
Volume: 110(20)
Issue: 20
Pages: 8134-8139
DOI
Related Report
Peer Reviewed
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[Journal Article] Investigation of the association between Toll-like receptor 9 gene polymorphisms and sarcoidosis in Japanese patients.2013
Author(s)
Yotsumoto S, Meguro A, Ishihara M, Uemoto R, Ota M, Morimoto S, Kaburaki T, Ando Y, Takenaka S, Ohno S, Inoko H, Mizuki N
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Journal Title
Ocul Immunol Inflamm
Volume: 21(3)
Issue: 3
Pages: 234-236
DOI
Related Report
Peer Reviewed
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[Journal Article] Interleukin 1 beta promoter polymorphism is associated with keratoconus in a Japanese population2013
Author(s)
Mikami T, Meguro A, Teshigawara T, Takeuchi M, Uemoto R, Kawagoe T, Nomura E, Asukata Y, Ishioka M, Iwasaki M, Fukagawa K, Konomi K, Shimazaki J, Nishida T, Mizuki N
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Journal Title
Mol Vis
Volume: 19
Pages: 845-851
URL
Related Report
Peer Reviewed
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