| Project/Area Number |
23590382
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human genetics
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| Research Institution | Yokohama City University |
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Principal Investigator |
NOMURA Naoko 横浜市立大学, 医学部, 助教 (40537205)
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| Co-Investigator(Kenkyū-buntansha) |
MIZUKI Nobuhisa 横浜市立大学, 医学研究科, 教授 (90336579)
MEGURO Akira 横浜市立大学, 医学研究科, 特任講師 (60508802)
KAWAGOE Tatsutaka 横浜市立大学, 医学部, 助教 (20564800)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 近視 / 遺伝子 / 国際情報交流（中国、台湾、シンガポール） |
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| Research Abstract |
In this study, we performed a genome-wide association study (GWAS) of high myopia using multiple ethnic groups (Japanese, Taiwanese, Chinese, Chinese Singaporean) and identified two genetic loci showing a significant association with the risk of high myopia in all ethnic groups. Our genetic findings may lead to clarify a pathogenic mechanism of high myopia.
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