Research Project
Grant-in-Aid for Scientific Research (C)
We have reported that autologous hematopoietic stem cell transplantation (HSCT) leads to an induction of antitumor immunity. However, many solid cancers are resistant to immune therapies, because they establish the immunosuppressive microenvironment in tumors. The regulatory T cells (Tregs) is a main factor of tumoral immunosuppression. On the other hand, the systemic depletion of Tregs may induce autoimmune reaction. Here, we developed a novel immune therapy with the genetic engineering of hematopoietic stem cells, which fundamentally break the immunosuppressive microenvironment in tumors. To eradicate Tregs in tumors only, we first analyzed the dynamics of Tregs in tumors after HSCT, and based the findings, we successfully developed a hypoxia-inducible Treg-specific transgene expression system, which is a basis of novel immune therapy.
All 2014 2013 2012 2011
All Journal Article (10 results) (of which Peer Reviewed: 6 results) Presentation (20 results) (of which Invited: 1 results) Book (2 results)
Cancer Science
Volume: 105 Issue: 2 Pages: 636-645
10.1111/cas.12332
Cancer Med
Volume: 2 Pages: 636-645
J Immunol
Volume: 191 Pages: 3440-3452
Journal of Immunology
Volume: 191 Issue: 6 Pages: 3440-3452
10.4049/jimmunol.1201454
Cancer Medicine
Volume: 2 Issue: 5 Pages: 636-645
10.1002/cam4.117
Hum. Gene Ther
Volume: 23 Pages: 173-186
Gene Ther
Volume: 19 Pages: 34-48
Immunology Letters
Volume: 144巻 Issue: 1-2 Pages: 33-40
10.1016/j.imlet.2012.03.004
Human Gene Therapy
Volume: 23 Issue: 2 Pages: 173-186
10.1089/hum.2011.046
Gene Therapy
Volume: 287 Issue: 1 Pages: 1397-1405
10.1038/gt.2011.73