| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Research Abstract |
ER beta is well known to play important roles in the pathogenesis of prostate cancer. Increased expression of 5-HT receptor, especially type 4 (5-HTR4), has been also proposed to be involved in the pathogenesis and peritumoral mast cells have been known to be histopatohologically present. In our immunohistochemical analysis (n=112), 5-HTR4 immunoreactivity was detected in 34% cases, and its immunoreactivity was significantly correlated with that of ER beta. Peritumoral mast cells, a potential site of serotonin production, were abundant within the tissues. 24h incubation of LNCaP cells with 5-HTR4 agonist increased the expression level of ER beta mRNA, while inhibited migration of cancer cells compared to controls.These findings indicated that 5-HTR4 may be involved in the pathogenesis of human prostate cancer cells possibly through 5-HT secreted by peritumoral mast cells.
|
