Significance of DNA damage response in cancerization in ulcerative colitis

• Project/Area Number: 23590391
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Niigata University
• Principal Investigator: AJIOKA Yoichi 新潟大学, 医歯学系, 教授 (80222610)
• Co-Investigator(Kenkyū-buntansha): WAKAI Toshifumi 新潟大学, 医歯学系, 教授 (50372470)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: 炎症性発癌 / 潰瘍性大腸炎 / 大腸癌 / DNA二重鎖切断 / DNA損傷応答 / 免疫組織化学 / dysplasia

Research Abstract

Inflammatory mucosa in ulcerative colitis showed elevated level of DNA damages (DNA double strand breaks) and cancerization in UC may be prepared in such DNA damaged mucosa. Invasive carcinoma in ulcerative colitis showed significantly low level of DNA damage response than early phase of cancerization process. In comparison with sporadic tumors, invasive carcinoma in ulcerative colitis showed significantly low level of DNA damage response. By these data, it is speculated that DNA damages and early failure of DNA damage responese may occurred during inflammatory cancerization process in UC.

Research Products

• [Journal Article] Alteration of DNA damage resopnse in colorectal tumor progression (2013)
  • Author(s): Takabayashi H, Wakai T, Ajioka Y, Korita, Yamaguchi N
  • Journal Title: Human Pathol Volume: 44 Issue: 6 Pages: 1038-1046
  • DOI: 10.1016/j.humpath.2012.09.006
  • Peer Reviewed
• [Journal Article] Histopathologic characteristics and biopsy diagnosis of colorectal carcinoma in ulcerative colitis (2013)
  • Author(s): 味岡洋一, 佐野知江
  • Journal Title: Nippon Shokakibyo Gakkai Zasshi Volume: 110 Issue: 3 Pages: 379-384
  • DOI: 10.11405/nisshoshi.110.379
  • NAID: 10031156316
  • ISSN: 0446-6586, 1349-7693
  • Peer Reviewed
• [Journal Article] 潰瘍性大腸炎腫瘍―診療と研究の最前線―潰瘍性大腸炎関連腫瘍の病理―炎症性発癌と通常型大腸腫瘍との差異を中心に― (2013)
  • Author(s): 味岡洋一, 渡辺玄, 加藤卓
  • Journal Title: IBD Research Volume: 7,2 Pages: 85-89
  • URL: http://www.sentan.com/cgi-bin/db_n.cgi?mode=view_backno&no=963
• [Journal Article] 潰瘍性大腸炎における大腸癌の病理組織学的特徴と生検診断 (2013)
  • Author(s): 味岡洋一、佐野知江
  • Journal Title: 日本消化器病学会誌 Volume: 110 Pages: 379-384
  • NAID: 10031156316
• [Journal Article] Early DNA damage response in residual carcinoma in situ at ductal stumps and local recurrence in patients undergoing resection for extrahepatic cholangiocarcinoma (2012)
  • Author(s): Wakai T, Shirai Y, Sakata J, Korita PV, Ajioka Y, Hatakeyama K
  • Journal Title: J Hepatobiliary Pancreat Sci Volume: 11 Issue: 3 Pages: 362-369
  • DOI: 10.1007/s00534-012-0539-1
  • NAID: 10031168232
  • Peer Reviewed
• [Journal Article] Alteration of p53-binding protein 1 expression as a risk factor for local recurrence in patients undergoing resection for extrahepatic cholangiocarcinoma (2011)
  • Author(s): Wakai T, Shirai Y, Sakata J, Korita PV, Matsuda Y, Takamura M, Ohashi R, Nagahashi M, Ajioka Y, Hatakeyama K
  • Journal Title: International Journal of Oncology Volume: 38 Pages: 1227-1236
  • Peer Reviewed
• [Journal Article] RUNX3 copy number predicts the development of UC-associated colorectal cancer (2011)
  • Author(s): Watanabe T, Kobunai T, Ikeuchi H, Yamamoto Y, Matsuda K, Ishihara S, Nozawa K, Iimura H, Kanazawa T, Tanaka T, Yokoyama T, Konishi T, Eshima K, Ajioka Y, Hibi T, Watanabe M, Muto T, Nagawa H
  • Journal Title: International Journal of Oncology Volume: 38 Issue: 1 Pages: 201-2077
  • DOI: 10.3892/ijo_00000839
  • Peer Reviewed
• [Journal Article] Alteration of p53-binding protein 1 expression as a risk factor for local recurrence in patients undergoing resection for extrahepatic cholangiocarcinoma (2011)
  • Author(s): 若井俊文、松田康伸, 他8名
  • Journal Title: Int J Oncol Volume: 38 Issue: 5 Pages: 1227-1236
  • DOI: 10.3892/ijo.2011.959
  • Peer Reviewed
• [Presentation] 潰瘍性大腸炎の炎症性発癌過程におけるDNA損傷応答 (2013)
  • Author(s): 谷優佑, 味岡洋一, 渡辺佳緒里, 若井俊文, 山口尚之, 高林広明, 小林和恵
  • Organizer: 第102回日本病理学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2013-06-07
• [Presentation] 潰瘍性大腸炎における胃型粘液発現の検討 (2013)
  • Author(s): 渡辺佳緒里, 味岡洋一, 谷優佑, 小林和恵
  • Organizer: 第102回日本病理学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2013-06-07
• [Presentation] 潰瘍性大腸炎の炎症性発癌過程におけるDNA損傷 (2013)
  • Author(s): 谷 優佑、味岡洋一、 渡辺佳緒里、若井俊文、山口尚之、高林広明、小林和恵
  • Organizer: 第102回日本病理学会総会
  • Place of Presentation: 札幌
• [Presentation] 潰瘍性大腸炎の炎症性発癌過程におけるDNA損傷について (2013)
  • Author(s): 谷 優佑
  • Organizer: 第102回日本病理学会総会
  • Place of Presentation: 札幌
• [Presentation] パネルディスカッション3 Colitic cancerの診断と治療におけるup to date (2012)
  • Author(s): 味岡洋一
  • Organizer: 第67回日本大腸肛門病学会学術総会
  • Place of Presentation: 福岡
  • Year and Date: 2012-11-21
• [Presentation] コアシンポジウム2炎症性腸疾患:colitic cancerの診断と治療の進歩 (2012)
  • Author(s): 味岡洋一
  • Organizer: 第8回日本消化管学会総会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2012-02-11
• [Presentation] colitic cancerの診断と治療の進歩 (2012)
  • Author(s): 味岡洋一
  • Organizer: 第8回日本消化管学会(招待講演)
  • Place of Presentation: 仙台国際センター（仙台市）
• [Presentation] 内視鏡医のための病理セッション炎症性発癌の病理診断 (2011)
  • Author(s): 味岡洋一
  • Organizer: 第82回日本消化器内視鏡学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2011-10-22
• [Presentation] 大腸腫瘍の発育進展における, 53BP1を介したDNA損傷修復応答の変化 (2011)
  • Author(s): 高林広明, 味岡洋一, 若井俊文.
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-05
• [Presentation] 大腸腫瘍の発育進展における、53BP1を介したDNA損傷修復応答の変化 (2011)
  • Author(s): 高林広明
  • Organizer: 第70回日本癌学会
  • Place of Presentation: 名古屋国際会議場（名古屋市）
• [Presentation] 炎症性発癌の病理診断 (2011)
  • Author(s): 味岡洋一
  • Organizer: 第82回日本消化器内視鏡学会(招待講演)
  • Place of Presentation: 福岡サンパレス（福岡県）