• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Significance of DNA damage response in cancerization in ulcerative colitis

Research Project

Project/Area Number 23590391
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Human pathology
Research InstitutionNiigata University

Principal Investigator

AJIOKA Yoichi  新潟大学, 医歯学系, 教授 (80222610)

Co-Investigator(Kenkyū-buntansha) WAKAI Toshifumi  新潟大学, 医歯学系, 教授 (50372470)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords炎症性発癌 / 潰瘍性大腸炎 / 大腸癌 / DNA二重鎖切断 / DNA損傷応答 / 免疫組織化学 / dysplasia
Research Abstract

Inflammatory mucosa in ulcerative colitis showed elevated level of DNA damages (DNA double strand breaks) and cancerization in UC may be prepared in such DNA damaged mucosa. Invasive carcinoma in ulcerative colitis showed significantly low level of DNA damage response than early phase of cancerization process. In comparison with sporadic tumors, invasive carcinoma in ulcerative colitis showed significantly low level of DNA damage response. By these data, it is speculated that DNA damages and early failure of DNA damage responese may occurred during inflammatory cancerization process in UC.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (19 results)

All 2013 2012 2011

All Journal Article (8 results) (of which Peer Reviewed: 6 results) Presentation (11 results)

  • [Journal Article] Alteration of DNA damage resopnse in colorectal tumor progression2013

    • Author(s)
      Takabayashi H, Wakai T, Ajioka Y, Korita, Yamaguchi N
    • Journal Title

      Human Pathol

      Volume: 44 Issue: 6 Pages: 1038-1046

    • DOI

      10.1016/j.humpath.2012.09.006

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Histopathologic characteristics and biopsy diagnosis of colorectal carcinoma in ulcerative colitis2013

    • Author(s)
      味岡洋一, 佐野知江
    • Journal Title

      Nippon Shokakibyo Gakkai Zasshi

      Volume: 110 Issue: 3 Pages: 379-384

    • DOI

      10.11405/nisshoshi.110.379

    • NAID

      10031156316

    • ISSN
      0446-6586, 1349-7693
    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 潰瘍性大腸炎腫瘍―診療と研究の最前線―潰瘍性大腸炎関連腫瘍の病理―炎症性発癌と通常型大腸腫瘍との差異を中心に―2013

    • Author(s)
      味岡洋一, 渡辺玄, 加藤卓
    • Journal Title

      IBD Research

      Volume: 7,2 Pages: 85-89

    • URL

      http://www.sentan.com/cgi-bin/db_n.cgi?mode=view_backno&no=963

    • Related Report
      2013 Final Research Report
  • [Journal Article] 潰瘍性大腸炎における大腸癌の病理組織学的特徴と生検診断2013

    • Author(s)
      味岡洋一、佐野知江
    • Journal Title

      日本消化器病学会誌

      Volume: 110 Pages: 379-384

    • NAID

      10031156316

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Early DNA damage response in residual carcinoma in situ at ductal stumps and local recurrence in patients undergoing resection for extrahepatic cholangiocarcinoma2012

    • Author(s)
      Wakai T, Shirai Y, Sakata J, Korita PV, Ajioka Y, Hatakeyama K
    • Journal Title

      J Hepatobiliary Pancreat Sci

      Volume: 11 Issue: 3 Pages: 362-369

    • DOI

      10.1007/s00534-012-0539-1

    • NAID

      10031168232

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Alteration of p53-binding protein 1 expression as a risk factor for local recurrence in patients undergoing resection for extrahepatic cholangiocarcinoma2011

    • Author(s)
      Wakai T, Shirai Y, Sakata J, Korita PV, Matsuda Y, Takamura M, Ohashi R, Nagahashi M, Ajioka Y, Hatakeyama K
    • Journal Title

      International Journal of Oncology

      Volume: 38 Pages: 1227-1236

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] RUNX3 copy number predicts the development of UC-associated colorectal cancer2011

    • Author(s)
      Watanabe T, Kobunai T, Ikeuchi H, Yamamoto Y, Matsuda K, Ishihara S, Nozawa K, Iimura H, Kanazawa T, Tanaka T, Yokoyama T, Konishi T, Eshima K, Ajioka Y, Hibi T, Watanabe M, Muto T, Nagawa H
    • Journal Title

      International Journal of Oncology

      Volume: 38 Issue: 1 Pages: 201-2077

    • DOI

      10.3892/ijo_00000839

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alteration of p53-binding protein 1 expression as a risk factor for local recurrence in patients undergoing resection for extrahepatic cholangiocarcinoma2011

    • Author(s)
      若井俊文、松田康伸, 他8名
    • Journal Title

      Int J Oncol

      Volume: 38 Issue: 5 Pages: 1227-1236

    • DOI

      10.3892/ijo.2011.959

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 潰瘍性大腸炎の炎症性発癌過程におけるDNA損傷応答2013

    • Author(s)
      谷優佑, 味岡洋一, 渡辺佳緒里, 若井俊文, 山口尚之, 高林広明, 小林和恵
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2013-06-07
    • Related Report
      2013 Final Research Report
  • [Presentation] 潰瘍性大腸炎における胃型粘液発現の検討2013

    • Author(s)
      渡辺佳緒里, 味岡洋一, 谷優佑, 小林和恵
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2013-06-07
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 潰瘍性大腸炎の炎症性発癌過程におけるDNA損傷2013

    • Author(s)
      谷 優佑、味岡洋一、 渡辺佳緒里、若井俊文、山口尚之、高林広明、小林和恵
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
  • [Presentation] 潰瘍性大腸炎の炎症性発癌過程におけるDNA損傷について2013

    • Author(s)
      谷 優佑
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] パネルディスカッション3 Colitic cancerの診断と治療におけるup to date2012

    • Author(s)
      味岡洋一
    • Organizer
      第67回日本大腸肛門病学会学術総会
    • Place of Presentation
      福岡
    • Year and Date
      2012-11-21
    • Related Report
      2013 Final Research Report
  • [Presentation] コアシンポジウム2炎症性腸疾患:colitic cancerの診断と治療の進歩2012

    • Author(s)
      味岡洋一
    • Organizer
      第8回日本消化管学会総会学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2012-02-11
    • Related Report
      2013 Final Research Report
  • [Presentation] colitic cancerの診断と治療の進歩2012

    • Author(s)
      味岡洋一
    • Organizer
      第8回日本消化管学会(招待講演)
    • Place of Presentation
      仙台国際センター(仙台市)
    • Related Report
      2011 Research-status Report
  • [Presentation] 内視鏡医のための病理セッション炎症性発癌の病理診断2011

    • Author(s)
      味岡洋一
    • Organizer
      第82回日本消化器内視鏡学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2011-10-22
    • Related Report
      2013 Final Research Report
  • [Presentation] 大腸腫瘍の発育進展における, 53BP1を介したDNA損傷修復応答の変化2011

    • Author(s)
      高林広明, 味岡洋一, 若井俊文.
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-05
    • Related Report
      2013 Final Research Report
  • [Presentation] 大腸腫瘍の発育進展における、53BP1を介したDNA損傷修復応答の変化2011

    • Author(s)
      高林広明
    • Organizer
      第70回日本癌学会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Related Report
      2011 Research-status Report
  • [Presentation] 炎症性発癌の病理診断2011

    • Author(s)
      味岡洋一
    • Organizer
      第82回日本消化器内視鏡学会(招待講演)
    • Place of Presentation
      福岡サンパレス(福岡県)
    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi