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Therapeutic approaches for biliary dysgenesis of the PCK rat, an animal model of Caroli's disease with congenital hepatic fibrosis

Research Project

Project/Area Number 23590392
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Human pathology
Research InstitutionKanazawa University

Principal Investigator

SATO Yasunori  金沢大学, 医学系, 講師 (30324073)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords人体病理学 / 肝臓 / 胆管細胞 / 肝線維嚢胞性疾患
Research Abstract

Using the PCK rat, an animal model of Caroli's disease with congenital hepatic fibrosis, the involvement of the PI3K/Akt/mTOR pathway in biliary dysgenesis was examined in terms of therapeutic application. NVP-BEZ235 (an inhibitor of PI3K and mTOR) significantly inhibited cell proliferative activity and cystic growth of the cultured PCK cholangiocytes, which was accompanied by inhibition of apoptosis and induction of autophagy in the cells. In vivo, administration of NVP-BEZ235 significantly improved dilatation of intrahepatic bile ducts and liver fibrosis of the PCK rat.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (9 results)

All 2014 2013 2012 2011

All Journal Article (6 results) (of which Peer Reviewed: 3 results) Presentation (3 results)

  • [Journal Article] Activation of the PI3K/mTOR pathway is involved in cystic proliferation of cholangiocytes of the PCK rat2014

    • Author(s)
      Ren XS, Sato Y, Harada K, Sasaki M, Furubo S, Song JY, Nakanuma Y
    • Journal Title

      PLoS One

      Volume: 9(1) Issue: 1 Pages: e87660-e87660

    • DOI

      10.1371/journal.pone.0087660

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Caroli病と先天性肝線維症の病態解析-動物モデルPCKラットから得られた新たな知見2013

    • Author(s)
      佐藤保則
    • Journal Title

      金沢大学十全医学会雑誌

      Volume: 122 Pages: 24-28

    • NAID

      10031193190

    • Related Report
      2013 Final Research Report
  • [Journal Article] Therapeutic approaches for biliary dysgenesis of the PCK rat, an animal model of Caroli's disease with congenital hepatic fibrosis2013

    • Author(s)
      Sato Y, Ren XS, Nakanuma Y
    • Journal Title

      Pediatrics & Therapeutics

      Volume: 03 Issue: 04 Pages: 1000166-1000166

    • DOI

      10.4172/2161-0665.1000166

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] Caroli病と先天性肝線維症の病態解析ー動物モデルPCKラットから得られた新たな知見2013

    • Author(s)
      佐藤保則
    • Journal Title

      金沢大学十全医学会雑誌

      Volume: 122 Pages: 24-28

    • NAID

      10031193190

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Caloli's desease: Current knouledge of its biliary pathogenesis obtained from an orthologous rat model2012

    • Author(s)
      Sato Y, Ren XS, Nakanuma Y
    • Journal Title

      International Journal of Hepatology

      Volume: 107945 Pages: 10-10

    • DOI

      10.1155/2012/107945

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Biliary infection may exacerbate biliary cystogenesis through the induction of VEGF in cholangiocytes of the polycystic kidney (PCK) rat2011

    • Author(s)
      Ren XS, Sato Y, Harada K, Sasaki M, Yoneda N, Lin ZH, Nakanuma Y
    • Journal Title

      Am J Pathol

      Volume: 179(6) Issue: 6 Pages: 2845-2854

    • DOI

      10.1016/j.ajpath.2011.08.028

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Effects of mTOR inhibitors on the biliary cystogenesis of the PCK rat, an animal model of Caroli's disease2011

    • Author(s)
      Sato Y, Ren XS, Harada K, Sasaki M, Nakanuma Y
    • Organizer
      第62回米国肝臓病学会
    • Place of Presentation
      モスコーンセンター, サンフランシスコ
    • Related Report
      2013 Final Research Report
  • [Presentation] カロリ病モデルPCKラットにおけるmTOR阻害薬による胆管上皮細胞の増殖抑制効果2011

    • Author(s)
      任香善,佐藤保則,原田憲一,佐々木素子,中沼安二.
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      パシフィコ横浜, 横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] Effects of mTOR inhibitors ....2011

    • Author(s)
      Sato Y
    • Organizer
      第62回米国肝臓病学会
    • Place of Presentation
      モスコーンセンター(米国)
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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