Elucidation of the molecular mechanisms and prognostic perspectives for ovarian cancer induced by iron overload due to endometriosis
Project/Area Number |
23590394
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Human pathology
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Research Institution | Nagoya City University (2012-2013) Nagoya University (2011) |
Principal Investigator |
YAMASHITA Yoriko 名古屋市立大学, 医学(系)研究科(研究院), 講師 (90303643)
|
Co-Investigator(Kenkyū-buntansha) |
TOYOKUNI Shinya 名古屋大学, 大学院医学系研究科, 教授 (90252460)
|
Co-Investigator(Renkei-kenkyūsha) |
YATABE Yasushi 愛知県がんセンター中央病院, 遺伝子病理 診断部, 部長 (90280809)
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Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 卵巣明細胞腺癌 / 子宮内膜症 / Met / 酸化ストレス / CBX7 / Met遺伝子 / 過剰鉄発がん / p16INK4A / Cbx7 / ANRIL / napsin A / 卵巣がん / 網羅的解析 |
Research Abstract |
Previous reports indicated that ovarian endometrioid and clear cell adenocarcinoma develop in association with oxidative stress due to excess of iron deposit. In this term, we performed array CGH analysis to find Met gene amplification in a certain proportion of ovarian clear cell adenocarcinoma samples correlated with worse prognosis (Yamashita et al. PLoS One 2013). Expression of CBX7, which is known to collaborate with the ANRIL gene reported to be associated with endometriosis, also had relationship with worse prognosis of the patients (Shinjo K, Yamashita Y et al. Int J Cancer 2014). We also analyzed the role of ectopic stromal cells in endometriotic cysts (Kobayashi H, Yamashita Y et al Fertil Steril 2012).
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Report
(4 results)
Research Products
(46 results)
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[Journal Article] Establishment of an Invasive Prostate Cancer Model in Transgenic Rats by Intermittent Testosterone Administration2014
Author(s)
Sato S, Suzuki S, Naiki-Ito A, Komiya M, Ne L, Kato H, Sagawa H, Yamashita Y, Shirai T, Takahashi S
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Journal Title
Journal of Toxicologic Pathology
Volume: 27
Issue: 1
Pages: 43-49
DOI
NAID
ISSN
0914-9198, 1881-915X
Related Report
Peer Reviewed
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[Journal Article] Preclinical evaluation of an O(6)-methylguanine-DNA methyltransferase-siRNA/liposome complex administered by convection-enhanced delivery to rat and porcine brains2014
Author(s)
Tsujiuchi T, Natsume A, Motomura K, Kondo G, Ranjit M, Hachisu R, Sugimura I, Tomita S, Takehara I, Woolley M, Barua NU, Gill SS, Bienemann AS, Yamashita Y, Toyokuni S, Wakabayashi T
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Journal Title
Am J Transl Res.
Volume: 6巻2号
Pages: 169-78
URL
Related Report
Peer Reviewed
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[Journal Article] Expression of chromobox homolog 7 (CBX7) is associated with poor prognosis in ovarian clear cell adenocarcinoma via TRAIL-induced apoptotic pathway regulation2014
Author(s)
Shinjo K, Yamashita Y, Yamamoto E, Akatsuka S, Uno N, Kamiya A, Niimi K, Sakaguchi Y, Nagasaka T, Takahashi T, Shibata K, Kajiyama H, Kikkawa F, Toyokuni S
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Journal Title
Int J Cancer
Volume: 135
Issue: 2
Pages: 308-318
DOI
Related Report
Peer Reviewed
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[Journal Article] Cancer-promoting role of adipocytes in asbestos-induced mesothelial carcinogenesis through dysregulated adipocytokine production2013
Author(s)
S. H. Chew, Y. Okazaki, H. Nagai, N. Misawa, S. Akatsuka, K. Yamashita, L. Jiang, Y. Yamashita, M. Noguchi, K. Hosoda, Y. Sekido, T. Takahashi, S. Toyokuni
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Journal Title
Carcinogenesis
Volume: 35(1)
Issue: 1
Pages: 164-172
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Lack of presence of the human cytomegalovirus in human glioblastoma.2013
Author(s)
Yamashita Y, Ito Y, Isomura H, Takemura N, Okamoto A, Motomura K, Tsujiuchi T, Natsume A, Wakabayashi T, Toyokuni S, Tsurumi T
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Journal Title
Mod Pathol
Volume: Dec 13
Issue: 7
Pages: 922-9
DOI
Related Report
Peer Reviewed
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[Journal Article] β4GalT6 is involved in the synthesis of lactosylceramide with less intensity than β4GalT52013
Author(s)
Tokuda N, Numata S, Li X, Nomura T, Takizawa M, Kondo Y, Yamashita Y, Hashimoto N, Kiyono T, Urano T, Furukawa K, Furukawa K
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Journal Title
Glycobiology
Volume: 23
Issue: 10
Pages: 1175-1183
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Fenton reaction induced cancer in wild type rats recapitulates genomic alterations observed in human cancer.2012
Author(s)
Liu Y, Izumiya M, Abe K, Ochiai M, Jiang L, Nagai H, Okazaki Y, Murakami H, Sekido Y, Arai E, Kanai Y, Hino O, Takahashi T, Nakagama H, Toyokuni S
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Journal Title
PLoS One
Volume: 7
Issue: 8
Pages: e43403-e43403
DOI
Related Report
Peer Reviewed
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[Journal Article] Iron overload signature in chrysotile-induced malignant mesothelioma.2012
Author(s)
Jiang L, Akatsuka S, Nagai H, Chew SH, Ohara H, Okazaki Y, Yamashita Y, Yoshikawa Y, Yasui H, Ikuta K, Sasaki K, Kohgo Y, Hirano S, Shinohara Y, Kohyama N, Takahashi T, Toyokuni S.
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Journal Title
J Pathol
Volume: 228
Issue: 3
Pages: 366-77
DOI
Related Report
Peer Reviewed
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[Journal Article] The ferroimmunomodulatory role of ectopic endometriotic stromal cells in ovarian endometriosis.2012
Author(s)
Kobayashi H, Yamashita Y, Iwase A, Yoshikawa Y, Yasui H, Kawai Y, Uchida K, Uno N, Akatsuka S, Takahashi T, Kikkawa F, Toyokuni S.
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Journal Title
Fertil Steril
Volume: 98
Issue: 2
Pages: 415-22
DOI
Related Report
Peer Reviewed
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[Journal Article] The ferroimmunomodulatory role of ectopic endometriotic stromal cells in ovarian endometriosis2012
Author(s)
Kobyashi H, Yamashita Y, Iwase A, Yoshikawa Y, Yasui H, Kawai Y, Uchida K, Uno N, Akatuska S, Takahashi T, Kikkawa F, Toyokuni S.
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Journal Title
Fertility & Sterility
Volume: In press
Related Report
Peer Reviewed
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[Journal Article] Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis2011
Author(s)
Nagai H., Okazaki Y., Chew SH., Misawa N., Yamashita Y., Akatsuka S., Ishihara T., Yamashita K., Yoshikawa Y., Yasui H., Jiang L., Ohara H., Takahashi T., Ichihara G., Kostarelos K., Miyata Y., Shinohara H., Toyokuni S.
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Journal Title
Proceedings of the National Academy of Sciences USA
Volume: 108
Issue: 49
DOI
Related Report
Peer Reviewed
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