Importance of autophagy-associated molecules in lung cancer cases
| Project/Area Number |
23590395
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
CHANO Tokuhiro 滋賀医科大学, 医学部, 准教授 (40346028)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | tissue microarray / biomarker / autophagy / RB1CC1/FIP200 / p62/SQSTM1 / Nrf2 |
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| Research Abstract |
Stainings of autophagy-associated molecules, p62/SQSTM1 and RB1CC1, were scored by using a tissue microarray of lung cancers. RB1CC1 is expressed only in the cytoplasm of lung cancers, suggesting to the poor prognosis. p62/SQSTM1 accumulation was further associated with the worse survival, especially the worst in the cases with both expressions of p62/SQSTM1 and RB1CC1. p62/SQSTM1 could become a biomarker of worse prognosis in lung cancer cases.
In oral squamous cell carcinoma, p62/SQSTM1 contributed to induce glutathione in oral carcinoma cells, and to cause a resistance to radiaton therapy. Clinico-pathological detection of p62/SQSTM1 accumulation could predict poor prognosis, and could be a novel biomarker in the cases of oral squamous cell carcinomas.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] Profiling of Phospho-AKT, Phospho-mTOR, Phospho-MAPK and EGFR in Non-small Cell Lung Cancer2014
Author(s)
Kitano H, Chung JY, Ylaya K, Conway C, Takikita M, Fukuoka J, Doki Y, Hanaoka J, Hewitt SM
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Journal Title
J Histochem Cytochem
Volume: 62(5)
Pages: 335-346
Related Report
Peer Reviewed
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[Journal Article] Cell-cycle control in urothelial carcinoma : large-scale tissue array analysis of tumor tissue from Maine and Vermont2012
Author(s)
Lenz P, Pfeiffer R, Baris D, Schned AR, Takikita M, Poscablo MC, Schwenn M, Johnson A, Jones M, Kida M, Cantor KP, Rothman N, Silverman DT, Hewitt SM, Moore LE
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Journal Title
Cancer Epidemiol Biomarkers Prev
Volume: 21(9)
Pages: 1555-1564
Related Report
Peer Reviewed
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[Journal Article] Cell-cycle control in urothelial carcinoma: large-scale tissue array analysis of tumor tissue from Maine and Vermont.2012
Author(s)
Lenz P, Pfeiffer R, Baris D, Schned AR, Takikita M, Poscablo MC, Schwenn M, Johnson A, Jones M, Kida M, Cantor KP, Rothman N, Silverman DT, Hewitt SM, Moore LE.
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Journal Title
Cancer Epidemiol Biomarkers Prev.
Volume: 21(9)
Issue: 9
Pages: 1555-1564
DOI
Related Report
Peer Reviewed
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[Journal Article] Global gene expression profiling and validation in esophageal squamous cell carcinoma (ESCC) and its association with clinical phenotypes.2011
Author(s)
Su H, Hu N, Yang HH, Wang C, Takikita M, Wang QH, Giffen C, Clifford RJ, Hewitt SM, Shou JZ, Goldstein AM, Lee MP, Taylor PR.
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Journal Title
Clin Cancer Res
Volume: 17(9)
Pages: 2955-66
Related Report
Peer Reviewed
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