| Project/Area Number |
23590395
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
CHANO Tokuhiro 滋賀医科大学, 医学部, 准教授 (40346028)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | tissue microarray / biomarker / autophagy / RB1CC1/FIP200 / p62/SQSTM1 / Nrf2 |
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| Research Abstract |
Stainings of autophagy-associated molecules, p62/SQSTM1 and RB1CC1, were scored by using a tissue microarray of lung cancers. RB1CC1 is expressed only in the cytoplasm of lung cancers, suggesting to the poor prognosis. p62/SQSTM1 accumulation was further associated with the worse survival, especially the worst in the cases with both expressions of p62/SQSTM1 and RB1CC1. p62/SQSTM1 could become a biomarker of worse prognosis in lung cancer cases.
In oral squamous cell carcinoma, p62/SQSTM1 contributed to induce glutathione in oral carcinoma cells, and to cause a resistance to radiaton therapy. Clinico-pathological detection of p62/SQSTM1 accumulation could predict poor prognosis, and could be a novel biomarker in the cases of oral squamous cell carcinomas.
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