| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
Infiltration of M2 type macrophage in human esophageal squamous cell carcinomas (ESCCs) was associated with grade of malignancy and patients prognosis. Cyr61, extracted as one of the up-regulated genes during M2 differentiation of THP-1 human monocytic leukemia cell line by conditioned media of ESCC cell lines, induced expression of CD204 and migration of macrophages through activation of MEK/Erk signal pathways. GDF15, from activated human peripheral blood monocyte derived macrophage, promoted growth of ESCC cells by activating Akt and Erk. Activated macrophages promoted the growth of immortalized normal human esophageal squamous epithelial cells.
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