Analysis of M2 macrophage/cancer interaction in carcinogenesis, growth and progression of human esophageal squamous cell carcinoma
| Project/Area Number |
23590397
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Kobe University |
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Principal Investigator |
YOKOZAKI Hiroshi 神戸大学, 医学(系)研究科(研究院), 教授 (10200891)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 病理学 / 癌 / 食道 / マクロファージ / 癌・間質相互作用 |
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| Research Abstract |
Infiltration of M2 type macrophage in human esophageal squamous cell carcinomas (ESCCs) was associated with grade of malignancy and patients prognosis. Cyr61, extracted as one of the up-regulated genes during M2 differentiation of THP-1 human monocytic leukemia cell line by conditioned media of ESCC cell lines, induced expression of CD204 and migration of macrophages through activation of MEK/Erk signal pathways. GDF15, from activated human peripheral blood monocyte derived macrophage, promoted growth of ESCC cells by activating Akt and Erk. Activated macrophages promoted the growth of immortalized normal human esophageal squamous epithelial cells.
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Report
(4 results)
Research Products
(66 results)
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[Journal Article] Clinicopathological characteristics of abnormal micro-lesions at the oro-hypopharynx detected by a magnifying narrow band imaging system2012
Author(s)
Tanaka S, Morita Y, Fujita T, Yokozaki H, Obata D, Fujiwara S, Wakahara C, Masuda A, Sugimoto M, Sanuki T, Yoshida M, Toyonaga T, Kutsumi H, Azuma T
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Journal Title
Dig Endosc
Volume: 24巻
Issue: 2
Pages: 100-109
DOI
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Peer Reviewed
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[Presentation] 食道上皮内マクロファージ密度と上皮増殖性病変分布の相関2013
Author(s)
横崎宏, 森田康枝, 藤原もも, 中鉢亜弥, 深澤圭似子, 重岡学, 西尾真理, 裏川直樹, 綿島健人, 狛雄一朗, 仙波秀峰
Organizer
第102回日本病理学会総会
Place of Presentation
ロイトン札幌(札幌市)
Year and Date
2013-06-07
Related Report
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[Presentation] Direct cancer-stromal interaction increases fibroblast proliferation and enhances invasive properties of scirrhous-type gastric carcinoma cells2013
Author(s)
Urakawa N, Takase N, Shigeoka N, Nishio M, Watajima T, Utsunomiya S, Yashiro M, Hirakawa K, Koma Y, Semba S, Yanagihara K, Suzuki S, Kakeji Y, Yokozaki H
Organizer
The 4th JCA-AACR Special Joint Conference : The Latest Advances in Gastric Cancer Research
Place of Presentation
東京ベイ舞浜ホテル(浦安市)
Related Report
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[Presentation] Direct cancer-stromal interaction increases fibroblast proliferation and enhances invasive properties of scirrhous-type gastric carcinoma cells.2013
Author(s)
Naoki Urakawa, Nobuhisa Takase, Manabu Shigeoka, Mari Nishio, Taketo Watajima, Souken Utsunomiya, Masakazu Yashiro, Hirakawa Kose, Yuichiro Koma, Shuho Semba, Kazuyoshi Yanagihara, Satoshi Suzuki, Yoshihiro Kakeji, Hiroshi Yokozaki
Organizer
The 4th JCA-AACR Special Joint Conference: The Latest Advances in Gastric Cancer Research
Place of Presentation
東京ベイ舞浜ホテル（浦安市）
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