| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
Intrahepatic cholangiocarcinomas (ICCs) consist of heterogenous carcinoma arising from different anatomical sites of the liver. This heterogeneity depends on that the origin of ICCs is different level of biliary tree based on the gross and histologic examination. We examined oxidative stress marker related with carcinogenesis, Slit-ROBO1 signal pathway, and glucose metabolism in carcinogenesis and progression of ICCs, exept we did not perform the investigation of bile acid and its receptor in ICC. As a results, 1) cyclooxygenase-2 (COX2) expression is associated with VEGF-C expression and presence of lymph node metastasis, 2) decreased expression of ROBO1 by SiRNA in RBE cells is associated with proliferation and migration, and pomote lymph node metastasis, and 3) Glucose transporter-1 (GLUT1) expression is related with aggressive phenotype of ICCs.
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