| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
Atherosclerotic diseases are increasing as lifestyle-related diseases increased. We investigated the mechanisms of vascular impairments with the focus on angiogenic growth factors in several diseases. We revealed that VEGF-A and VEGF-C progressed atherosclerotic lesions of ApoE-KO mice. CKD is associated with an increased risk of coronary heart disease caused by the acceleration of chronic inflammation. In peritoneal dialysis patients, immature angiogenesis in peritoneum is related with peritoneal dysfunction. Lymphangiogenesis in renal cortex may improve interstitial damages in ureteral obstruction mice. From these findings, angiogenic growth factors have the effects of vascular repairs and injuries in various types of diseases.
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