Pathological research on angiogenic growth factors that have the aspects of vascular repair and injury
Project/Area Number |
23590400
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Human pathology
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Research Institution | Kyushu University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
ONIMARU Mitsuho 九州大学, 医学研究院, 助教 (00380626)
TSURUYA Kazuhiko 九州大学, 医学研究院, 准教授 (20372740)
TANIGUCHI Masatomo 九州大学, 医学研究院, 助教 (60419562)
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Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 血管新生 / 動脈硬化 / 慢性腎臓病 |
Research Abstract |
Atherosclerotic diseases are increasing as lifestyle-related diseases increased. We investigated the mechanisms of vascular impairments with the focus on angiogenic growth factors in several diseases. We revealed that VEGF-A and VEGF-C progressed atherosclerotic lesions of ApoE-KO mice. CKD is associated with an increased risk of coronary heart disease caused by the acceleration of chronic inflammation. In peritoneal dialysis patients, immature angiogenesis in peritoneum is related with peritoneal dysfunction. Lymphangiogenesis in renal cortex may improve interstitial damages in ureteral obstruction mice. From these findings, angiogenic growth factors have the effects of vascular repairs and injuries in various types of diseases.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Chronic kidney disease is associated with neovascularization and intraplaque hemorrhage in coronary atherosclerosis in elders : results from the Hisayama Study2013
Author(s)
Nakano T, Ninomiya T, Sumiyoshi S, Onimaru M, Fujii H, Itabe H, Nakashima Y, Sueishi K, Tsuruya K, Oda Y, Kitazono T, Kiyohara Y
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Journal Title
Kidney Int.
Volume: 84(2)
Pages: 373-80
NAID
Related Report
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[Journal Article] Chronic kidney disease is associated with neovascularization and intraplaque hemorrhage in coronary atherosclerosis in elders: results from the Hisayama Study.2013
Author(s)
Nakano T, Ninomiya T, Sumiyoshi S, Onimaru M, Fujii H, Itabe H, Nakashima Y, Sueishi K, Tsuruya K, Oda Y, Kitazono T, Kiyohara Y.
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Journal Title
Kidney Int
Volume: 84
Issue: 2
Pages: 373-380
DOI
Related Report
Peer Reviewed
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[Journal Article] Chronic kidney disease is associated with neovascularization and intraplaque hemorrhage in coronary atherosclerosis in elders: results from the Hisayama Study2013
Author(s)
T Nakano, T Ninomiya, S Sumiyoshi, M Onimaru, H Fujii, H Itabe, Y Nakashima, Katsuo Sueishi, Kazuhiko Tsuruya, Y Oda, T Kitazono, Y Kiyohara
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Journal Title
Kidney International
Volume: 掲載予定
NAID
Related Report
Peer Reviewed
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[Presentation] Glucose degradation product methylglyoxal induces immature angiogenesis and peritoneal dysfunction in peritoneal membrane in patients undergoing peritoneal dialysis2013
Author(s)
Toshiaki Nakano, Tohru Mizumasa, Hisako Yoshida, Masahiro Eriguchi, Masatomo Taniguchi, Kosuke Masutani, Hideki Hirakata, Kazuhiko Tsuruya, Takanari Kitazono
Organizer
American Society of Nephrology, Kidney Week 2013 Annual Meeting
Place of Presentation
Atlanta, GA, USA
Related Report
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